Elimination of sulphamerazine has been studied by many investigators in cows (MACLAY and SLAVIN, 1947;PAAR et al., 1964;SCHIPPER and EVELETH, 1959; SHUHARDT et al., 1948 and SISODIA and STOWE, 1964) and in man (FRIESEN, 1951;GAMKLOU et al., 1962 andWELLING andDIENSBERG, 1951).The present investigation concerns the mammary and renal excretion of suIphamerazine in ewes.
Material and MethodsSulphamerazine powder (A/S Syntetic, Aarhus, Denmark) was employed. Nine clinically healthy ewes weighing 35-51 kg. were used in ten experiments. Each ewe yielded 400-1,500 ml. milk per day, Sulphamerazine was dissolved in distilled water by heating and simultaneous addition of 5 N NaOH. The solution was then administered to ewes by an initial intravenous injection through a catheter ( Abbocath-T) placed in the