Vergleich von Schweinen, Schafen und Nagern aus biomedizinischer Sicht

Sipos, Wolfgang

doi:10.1007/978-3-662-65844-4_1

Cited by 1 publication

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, a surgical model of hypoparathyroidism is most suitable to meet clear criteria. Large animal models (sheep and pig)—although their immune system is also well characterized meanwhile ( 81 , 110 , 111 ), which is an argument in favor of their increased use in biomedical research in general, but also in osteological research in special ( 112 )—do not fulfill the requirements of surgical feasibility and have thus to be excluded for such experiments till real-time detection methods for hypoparathyroid tissues exist. A model widely used for hypoparathyroidism and offering high availability of analytical reagents is PTX in mice and rats.…”

Section: Discussionmentioning

confidence: 99%

Challenges in establishing animal models for studying osteoimmunology of hypoparathyroidism

et al. 2023

Self Cite

View full text Add to dashboard Cite

Hypoparathyroidism is a relatively rare human and veterinary disease characterized by deficient or absent production of parathyroid hormone (PTH). PTH is known as a classical regulator of calcium and phosphorus homeostasis. Nevertheless, the hormone also appears to modulate immune functions. For example, increased CD4:CD8 T-cell ratios and elevated interleukin (IL)-6 and IL-17A levels were observed in patients with hyperparathyroidism, whereas gene expression of tumor necrosis factor-α (TNF-α) and granulocyte macrophage-colony stimulating factor (GM-CSF) was decreased in patients with chronic postsurgical hypoparathyroidism. Various immune cell populations are affected differently. So, there is a need for validated animal models for the further characterization of this disease for identifying targeted immune-modulatory therapies. In addition to genetically modified mouse models of hypoparathyroidism, there are surgical rodent models. Parathyroidectomy (PTX) can be well performed in rats—for pharmacological and associated osteoimmunological research and bone mechanical studies, a large animal model could be preferable, however. A major drawback for successfully performing total PTX in large animal species (pigs and sheep) is the presence of accessory glands, thus demanding to develop new approaches for real-time detection of all parathyroid tissues.

show abstract