Vereinfachte Auslegung der simulierten Gegenstromchromatographie mittels des Hodographenraums

Kaspereit, Malte; Neupert, Bernhard

doi:10.1002/cite.201600072

Cited by 6 publications

(2 citation statements)

References 68 publications

(87 reference statements)

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“…Figure 3 also shows the region where conditions ( 18) and ( 21) are fulfilled for m1/m4. This orange triangle indicates the regeneration region [48][49][50].…”

Section: Triangle Theorymentioning

confidence: 99%

Residence Time Section Evaluation and Feasibility Studies for One-Column Simulated Moving Bed Processes (1-SMB)

2023

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The simulated moving bed (SMB) is a well-established, fully continuous process for chromatographic separation of difficult tasks with overlapping peaks, but it is relatively complex. The 1-SMB, which uses only one column but includes residence time zones to preserve concentration profiles, is a simpler semi-continuous alternative. This work examines the possible design of these residence time zones. Simulation studies were conducted to investigate the dependence of process metrics, such as purity, yield, productivity, and eluent consumption, on fluid dynamics. No deterioration in purity was observed, and the other variables remained constant over a wide range of axial dispersion before decreasing sharply. Pilot-scale experiments were conducted with various devices, including coiled flow inverters, eluate recycling devices, packed columns, and tank arrangements, to validate possible apparatus implementations with fluid dynamic measurements. It was demonstrated that the 1-SMB offers similar performance to the 4-SMB, albeit with reduced yield and lower apparatus complexity.

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“…Figure 3 also shows the region where conditions ( 18) and ( 21) are fulfilled for m1/m4. This orange triangle indicates the regeneration region [48][49][50].…”

Section: Triangle Theorymentioning

confidence: 99%

Residence Time Section Evaluation and Feasibility Studies for One-Column Simulated Moving Bed Processes (1-SMB)

2023

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show abstract

“…The latter is often used to describe enantiomers also considered in this paper. In the case of Bi-Langmuir isotherms, the design is not explicit anymore leading to different shortcuts as discussed in [6,7]. An extension of this design approach to processes with Langmuir isotherms and reduced purities was discussed in [8].…”

Section: Introductionmentioning

confidence: 99%