Verbascoside—A Review of Its Antitumor Activities

Khalaf, Hasan Alaa Aldeen; Jasim, Ruaa Azziz; Ibrahim, I. T.

doi:10.4236/pp.2021.126011

Cited by 12 publications

(8 citation statements)

References 85 publications

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“…Cytotoxic effect of condensed tannins was reported against MCF-7 and Hs 578T breast cancer cells, Caco-2 colon carcinoma cells, and DU 145 prostate cancer cells [ 105 ]. Cytotoxic effect against MDA-MB-231 (IC 50 = 0.159–0.258 μM) [ 106 ] and a range of other cancer cell lines, including U87 glioblastoma cell line, was reported for verbascoside [ 107 ], the major phenylethanoid of investigated species.…”

Section: Resultsmentioning

confidence: 99%

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

et al. 2022

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Species from the genus Globularia L. have been used as healing agents for various ailments, with utilization of Globularia alypum L. being most frequently reported. The aim of this study was to evaluate the antidiabetic, antioxidant, anti-inflammatory, antibacterial and anticancer potential of G. alypum and three related species, G. punctata Lapeyr., G. cordifolia L. and G. meridionalis (Podp.) O.Schwarz, in relation to their phytochemical compositions. Globularin and verbascoside were identified using LC-PDA-ESI-MSn as the major metabolites of G. alypum with known biological activities. G. alypum demonstrated the greatest α-glucosidase inhibitory activity and DPPH radical scavenging activity (IC50 = 17.25 μg/mL), while its anti-inflammatory activity was not significantly different from those of related species. All investigated species showed considerable antibacterial activity against methicillin-resistant Staphylococcus aureus in the broth microdilution method (MIC = 1.42–3.79 mg/mL). G. punctata also showed antibacterial activities against Escherichia coli (MIC = 1.42 mg/mL), Bacillus subtilis (MIC = 1.89 mg/mL), B. cereus (MIC = 2.84 mg/mL) and Enterococcus faecalis (MBC = 5.68 mg/mL). G. punctata, G. cordifolia and G. meridionalis showed greater anticancer potential than G. alypum. Obtained results indicate investigated Globularia species could serve as sources of diverse bioactive molecules, with G. punctata having the greatest antibacterial potential.

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Section: Resultsmentioning

confidence: 99%

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

et al. 2022

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“…Currently, TCM is a promising alternative adjuvant to traditional chemotherapy, which is advantageous for the prevention and treatment of OC (46,47). VB is a bioactive constituent of diverse Chinese herbs that possess anti-cancer activities (48). In this study, we found that VB inhibited the proliferation and migration, and induced the apoptosis of OC cells.…”

Section: Discussionmentioning

confidence: 55%

“…Moreover, we clarified the mechanism by which VB induces M1 polarization, which is regulated by the CCN1-mediated AKT/NF-kB signalling pathway. VB is a naturally occurring secondary metabolite widely existed in the plant kingdom, and possesses anti-tumour activity for the treatment of various cancers, such as human oral squamous cell carcinoma, colorectal cancer, and glioblastoma (33,(48)(49)(50). Zhang et al demonstrated that VB effectively inhibited the growth and metastasis of human oral squamous cell carcinoma cells (49).…”

Section: Discussionmentioning

confidence: 99%

The Anti-Tumor Efficacy of Verbascoside on Ovarian Cancer via Facilitating CCN1-AKT/NF-κB Pathway-Mediated M1 Macrophage Polarization

Zhao

et al. 2022

Front. Oncol.

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BackgroundOvarian cancer (OC) is the leading cause of gynecological cancer-related mortality. Verbascoside (VB) is a phenylpropanoid glycoside from Chinese herbs, with anti-tumour activities. This study aimed to investigate the effects and mechanism of VB on OC.MethodsOC cell lines SKOV3 and A2780 were used in this study. Cell viability, proliferation, and migration were measured using CCK-8, clonogenic, and transwell assays, respectively. Apoptosis and M1/M2 macrophages were detected using flow cytometry. The interaction between VB and CCN1 was predicted by molecular docking. The mRNA expression of CCN1 was detected by RT-qPCR. The protein levels of CCN1, AKT, p-AKT, p65, and p-p65 were determined by western blotting. A xenograft mice model was established for in vivo validation.ResultsVB inhibited OC cell proliferation and migration in a dose-dependent manner, and promoted apoptosis and M1 macrophage polarization. VB downregulated CCN1 and inhibited the AKT/NF-κB pathway. LY294002, an AKT inhibitor, potentiated the anti-tumour effects of VB. CCN1 overexpression weakened the anti-tumour effects of VB and VB + LY294002. In vivo experiments verified that VB inhibited tumour growth and promoted M1 polarization, which is regulated by the CCN1-mediated AKT/NF-κB pathway.ConclusionVB triggers the CCN1-AKT/NF-κB pathway-mediated M1 macrophage polarization for protecting against OC.

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“…It is pharmacologically active compound and known that has antitumor effect, cytotoxic selectivity and anticancer activity in in vitro and in vivo studies. [38,39] It also possesses antioxidant, anti-inflammatory properties. [40] The other compound with the highest amount (10873.09 mg/kg) in the extract is chlorogenic acid, readily found in food, medicines and cosmetics (Figure 1 and Table 6).…”

Section: Resultsmentioning

confidence: 99%

Endemic Mountain Tea (Sideritis dichotoma Huter): Antioxidant and Antibacterial Activities, Mineral Content by ICP‐MS and Phytochemical Content by LCHR‐MS

Öztürk Sarıkaya,

Zehiroğlu

2023

Chemistry & Biodiversity

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Endemic Sideritis dichotoma Huter, herbal tea, is used for colds, coughs and digestive ailments. Since at least 25% of the active ingredients of pharmacological drugs are obtained from plants, it is important to investigate many plants, both traditionally used and whose potential hasnt yet been discovered, before they disappear. When the results compared to other Sideritis species, it has better antioxidant activity in DPPH• scavenging activity, Fe3+ and Cu2+ reducing capacity methods and is also rich in minerals, necessary for human body, K, Mg, Ca, P, S. Zone values (10‐19,5 mm) obtained on S. aureus, P. aeruginosa, E. coli, S.enteritidis, E. faecalis, P. putida and K. pnemoniae strains are an indication that the plant has antibacterial activity. 27 secondary metabolites were identified by LC‐HRMS. Verbascoside, pharmacologically active compound known to have antitumor effect, cytotoxic selectivity and anticancer activity, is the most abundant phenolic in ethanol extract (49297.13 mg/kg).

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Verbascoside—A Review of Its Antitumor Activities

Cited by 12 publications

References 85 publications

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

The Anti-Tumor Efficacy of Verbascoside on Ovarian Cancer via Facilitating CCN1-AKT/NF-κB Pathway-Mediated M1 Macrophage Polarization

Endemic Mountain Tea (Sideritis dichotoma Huter): Antioxidant and Antibacterial Activities, Mineral Content by ICP‐MS and Phytochemical Content by LCHR‐MS

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