Verbal self-monitoring and auditory verbal hallucinations in patients with schizophrenia

Johns, Louise; Rossell, Susan L.; Frith, C. D.; Ahmad, Faizan; Hemsley, David R.; Kuipers, Elizabeth; McGuire, Philip

doi:10.1017/s0033291701003774

Cited by 239 publications

(203 citation statements)

References 30 publications

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“…Clinical observations reveal that schizophrenia is associated with both over-attributions (other-to-self-direction) as well as under-attributions (self-to-other direction). This is also reflected in the schizophrenia literature with respect to speech attribution (Johns et al, 2001, Johns et al, 2006, Stephane et al, 2009) and also with respect to incorrect agency attribution either to external sources or to the self (Daprati, et al, 1997, Fourneret, et al, 2001). In the majority of agency manipulation studies schizophrenia patients showed a tendency similar to that in our study, namely, a…”

Section: Sense Of Agency Deficits In Schizophreniamentioning

confidence: 93%

Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Schimansky

David

Rössler

et al. 2010

Psychiatry Research

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The sense of agency, i.e., the sense that "I am the one who is causing an action", and mentalizing, the ability to understand the mental states of other individuals, are key domains of social cognition. It has been hypothesized that an intact sense of agency is an important precondition for higher-level mentalizing abilities. A substantial body of evidence shows that both processes rely on similar brain areas and are severely impaired in schizophrenia, suggesting a close link between agency and mentalizing. Yet this relationship has not been explicitly tested. We investigated 40 individuals with schizophrenia and 40 healthy controls on an agency and mentalizing task. On the agency task, participants carried out simple mouse movements and judged the partially manipulated visual feedback as either self-or other-generated. On the mentalizing task, participants inferred mental states from pictures that depicted others' eyes ("Reading the mind in the eyes test"). Neuropsychological, psychopathological and social functioning levels were also evaluated. Both sense of agency and mentalizing were impaired in schizophrenia patients compared to healthy controls. However, testing for a relationship revealed no significant correlations between the two processes, either in the schizophrenia or the control group. The present findings demonstrate a dissociation of agency and mentalizing deficits in schizophrenia, suggesting that the multifaceted construct of social cognition consists of independent subdomains in healthy and psychiatrically ill individuals. AbstractThe sense of agency, i.e., the sense that "I am the one who is causing an action", and mentalizing, the ability to understand the mental states of other individuals, are key domains of social cognition. It has been hypothesized that an intact sense of agency is an important precondition for higher-level mentalizing abilities. A substantial body of evidence shows that both processes rely on similar brain areas and are severely impaired in schizophrenia, suggesting a close link between agency andmentalizing. Yet this relationship has not been explicitly tested. We investigated 40 individuals with schizophrenia and 40 healthy controls on an agency and mentalizing task. On the agency task, participants carried out simple mouse movements and judged the partially manipulated visual feedback as either self or other generated. On the mentalizing task, participants inferred mental states from pictures that depicted others' eyes ("Reading the Mind in the Eyes test"). Neuropsychological, psychopathological and social functioning levels were also evaluated.Both sense of agency and mentalizing were impaired in schizophrenics compared to healthy controls.However, testing for a relationship revealed no significant correlations between the two processes, either in the schizophrenia or the control group.The present findings demonstrate a dissociation of agency and mentalizing deficits in schizophrenia,suggesting that the multifaceted construct of social cognition consists of independ...

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Section: Sense Of Agency Deficits In Schizophreniamentioning

confidence: 93%

Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Schimansky

David

Rössler

et al. 2010

Psychiatry Research

View full text Add to dashboard Cite

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“…Cognitively, language deficits have been identified in children at risk for schizophrenia (Cannon et al, 2002;Fuller et al, 2002;Ott et al, 2001) as well as in patients in their first episode of psychosis (Fuller et al, 2002;Hoff et al, 1999). Numerous neuropsychological and psycholinguistic studies have established that patients with schizophrenia show selective language abnormalities as they monitor the source of verbal input (Ditman and Kuperberg, 2005;Johns et al, 2001), explicitly or implicitly retrieve information from semantic memory [e.g (Goldberg et al, 1998;Minzenberg et al, 2002)], select the appropriate meaning of semantically ambiguous words (Sitnikova et al, 2002;Titone et al, 2000), detect linguistic anomalies within sentences (Kuperberg et al, 2006a;Kuperberg et al, 1998;Kuperberg et al, 2000;Kuperberg et al, 2006b) and parse syntactically complex sentences (Condray et al, 1996) [for reviews, see (Kuperberg and Caplan, 2003;Kuperberg and Goldberg, 2006)]. Functional imaging studies report both abnormal increases and decreases in the recruitment of the left inferior prefrontal gyrus in schizophrenia during semantic tasks including encoding (Kubicki et al, 2003;Ragland et al, 2004), retrieval (Weiss et al, 2003) and priming (Kuperberg et al, 2007), although abnormal function in this region is not usually seen in isolation, but rather in association with abnormal modulation of other language regions including superior, inferior and medial temporal cortices.…”

Section: Functional Significance Of Abnormalities In Broca's Areamentioning

confidence: 99%

Abnormal cortical folding patterns within Broca's area in schizophrenia: Evidence from structural MRI

Wisco¹,

Kuperberg²,

Manoach³

et al. 2007

Schizophrenia Research

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We compared cortical folding patterns between patients with schizophrenia and demographicallymatched healthy controls in prefrontal and temporal regions of interest. Using the Freesurfer (http:// surfer.nmr.mgh.harvard.edu) cortical surface-based reconstruction methodology, we indirectly ascertained cortical displacement and convolution, together, by measuring the degree of metric distortion required to optimally register cortical folding patterns to an average template. An area within the pars triangularis of the left inferior frontal gyrus (Broca's area) showed significantly reduced metric distortion in the patient group relative to the control group (p = 0.0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia.

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“…Johns et al [8] assessed verbal self-monitoring in patients with schizophrenia who heard voices and had delusions (hallucinators). We induced verbal self-monitoring by manipulating auditory verbal feedback while participants spoke out loud, thus introducing a disparity between what individuals expected to hear and what they actually perceived.…”

Section: Introductionmentioning

confidence: 99%

Establishing the Reliability of a Verbal Self-Monitoring Paradigm

Johns

Gregg²,

Vythelingum³

et al. 2003

Psychopathology

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Background: Auditory hallucinations in schizophrenia are associated with defective monitoring of inner speech. This process can be examined using a computerised task of verbal self-monitoring. Cognitive therapy for voices aims to improve the patients’ self-monitoring ability, and changes in self-monitoring could be assessed using this task. Before using the paradigm in this way, we sought to determine its test re-test reliability. Sampling and Methods: 20 normal volunteers were tested on the paradigm on two occasions, 3 months apart. The task involved reading single adjectives under the following randomized conditions: reading aloud; reading aloud with acoustic distortion of their own voice; reading aloud with alien feedback (someone else’s voice), and reading aloud with distorted alien feedback. Immediately after articulating each word, the participants were required to identify the source of the speech they heard (‘self’/‘other’/‘unsure’) via a button press. Response choice and reaction time were recorded. Results: There was no change in error rate over the two testing occasions; however, participants had faster reaction times when tested for the second time. This reduction in reaction time was not specific to type of response (correct, error, unsure). Conclusions: Participants showed no evidence of practice on the paradigm in terms of making fewer errors or responding faster for correct responses. The overall reduction in reaction times on the second occasion may reflect increased familiarity with the task. The verbal self-monitoring paradigm appears to be a reliable measure, which could be used to evaluate changes in self-monitoring ability in hallucinators following psychological therapy.

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Verbal self-monitoring and auditory verbal hallucinations in patients with schizophrenia

Cited by 239 publications

References 30 publications

Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Sense of agency and mentalizing: Dissociation of subdomains of social cognition in patients with schizophrenia

Abnormal cortical folding patterns within Broca's area in schizophrenia: Evidence from structural MRI

Establishing the Reliability of a Verbal Self-Monitoring Paradigm

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