Verbal memory improvement in first-episode  psychosis &lt;em&gt;APOE-&lt;/em&gt;&amp;epsilon;4 carriers: a pleiotropic effect?

Vila‐Rodriguez, Fidel; Lang, Donna J.; Baitz, Heather A.; Gicas, Kristina M.; Thornton, Allen E.; Ehmann, Tom; Smith, Geoff; Barr, Alasdair M.; Kopala, Lili C.; MacEwan, G. William; Müller, Daniel J.; Kennedy, James L.; Honer, William G.

doi:10.2147/ndt.s150488

Cited by 6 publications

(4 citation statements)

References 56 publications

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“…In addition, a study found that schizophrenia patients with ApoEε4 carriers had significantly lower verbal memory score assessed by the Brief Assessment of Cognition in Schizophrenia (BACS) [22]. Another study showed an interaction between the ApoE ε4 allele, first-episode psychosis (FEP), and the improvement in verbal memory over time measured by California Verbal Learning Test (CVLT) [94]. These inconsistent findings of cognitive deficits in patients with schizophrenia may be partly due to the combined effects of different cognitive measurement tools and ApoE genotypes.…”

Section: Genotype Effects On Serum Apob Level and Cognition In Patientsmentioning

confidence: 99%

Association between cognitive impairment and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia

Rao

Zhang

et al. 2021

Aging

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ApoE gene polymorphism may be involved in the change in blood lipid profile and cognitive impairment of the general population. However, few studies explored the effects of ApoE gene polymorphism on blood lipid levels and cognition in schizophrenia. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was employed to evaluate the cognition and the SNPStats was used to investigate the association of ApoE rs429358 with schizophrenia. The models of analysis of covariance and multivariate analysis were conducted to investigate the effect of ApoE rs429358 on cognition in schizophrenia. Altogether, 637 patients with schizophrenia and 467 healthy controls were recruited in this study. The findings in the case group found that both the ApoA1 and ApoB levels were predictors for RBANS total score (p < 0.001 vs. p = 0.011), immediate memory (p < 0.001 vs. p = 0.019), language (p < 0.001 vs. p = 0.013), attention (p < 0.001 vs. p < 0.001), except ApoA1 level only was a predictor for visuospatial/constructional (p = 0.014) and delayed memory (p < 0.001). When the association was examined in different ApoE rs429358 genotype subgroups, the association between ApoA1 level and RBANS scores (except for the language score) or between ApoB level and RBANS scores (except for the attention score) was regulated by ApoE rs429358. Our results suggest that patients with schizophrenia have broad cognitive impairment compared with healthy controls. For patients with schizophrenia, both ApoA1 and ApoB levels were positively associated with cognition. There was a significant association between ApoA1 or ApoB levels and cognition in schizophrenia, which was regulated by the ApoE rs429358.

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Section: Genotype Effects On Serum Apob Level and Cognition In Patientsmentioning

confidence: 99%

Association between cognitive impairment and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia

Rao

Zhang

et al. 2021

Aging

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“…Among the APOE polymorphism-associated traits that appear to have AP characteristics are included the different biochemical consequences that ApoE2, ApoE3, ApoE4 proteins have on the metabolism of cholesterol, which have important implications, among others, on the metabolism of β-amyloid and synaptogenesis resistance in younger vs. aged mammalians, and could so explain the “paradoxical” beneficial effects of APOE 4 on specific cognitive skills (e.g. verbal memory in schizophrenic patients [78], memory performance [79], and attention in young [80]), and the observation that APOE 4 is an advantageous factor on survival and infertility in infectious environments [81,82], or that APOE alleles are associated with conscientiousness personality-trait in relationship to gray matter volume [7] and greater cortical connectivity [83]. Figure 1 shows graphs describing the antagonistic pleiotropy concept applied to APOE polymorphism.…”

Section: Apoe and Antagonistic Pleiotropymentioning

confidence: 99%

Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

Iacono

Feltis

2019

Aging

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The central nervous system (CNS) is the cellular substrate for the integration of complex, dynamic, constant, and simultaneous interactions among endogenous and exogenous stimuli across the entire human lifespan. Numerous studies on aging-related brain diseases show that some genes identified as risk factors for some of the most common neurodegenerative diseases - such as the allele 4 of APOE gene (APOE4) for Alzheimer’s disease (AD) - have a much earlier neuro-anatomical and neuro-physiological impact. The impact of APOE polymorphism appears in fact to start as early as youth and early-adult life. Intriguingly, though, those same genes associated with aging-related brain diseases seem to influence different aspects of the brain functioning much earlier actually, that is, even from the neonatal periods and earlier. The APOE4, an allele classically associated with later-life neurodegenerative disorders as AD, seems in fact to exert a series of very early effects on phenomena of neuroplasticity and synaptogenesis that begin from the earliest periods of life such as the fetal ones.We reviewed some of the findings supporting the hypothesis that APOE polymorphism is an early modifier of various neurobiological aspects across the entire human lifespan - from the in-utero to the centenarian life - during both normal and pathological conditions of the brain.

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“…82 Thirteen studies obtained nonsignificant results. 59,60,[62][63][64]66,[70][71][72]76,81,83,84 Genome-wide association studies…”

Section: Other Candidate Genesmentioning

confidence: 99%

Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review

Murillo-García¹,

Barrio-Martínez

Setién-Suero

et al. 2022

jpn

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Background: To study whether there is genetic overlap underlying the risk for schizophrenia spectrum disorders (SSDs) and low intelligence quotient (IQ), we reviewed and summarized the evidence on genetic variants associated with both traits. Methods: We performed this review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and preregistered it in PROSPERO. We searched the Medline databases via PubMed, PsycInfo, Web of Science and Scopus. We included studies in adults with a diagnosis of SSD that explored genetic variants (single nucleotide polymorphisms [SNPs], copy number variants [CNVs], genomic insertions or genomic deletions), estimated IQ and studied the relationship between genetic variability and both traits (SSD and IQ). We synthesized the results and assessed risk of bias using the Quality of Genetic Association Studies (Q-Genie) tool. Results: Fifty-five studies met the inclusion criteria (45 case-control, 9 cross-sectional, 1 cohort), of which 55% reported significant associations for genetic variants involved in IQ and SSD. The SNPs more frequently explored through candidate gene studies were in COMT, DTNBP1, BDNF and TCF4. Through genome-wide association studies, 2 SNPs in CHD7 and GATAD2A were associated with IQ in patients with SSD. The studies on CNVs suggested significant associations between structural variants and low IQ in patients with SSD. Limitations: Overall, primary studies used heterogeneous IQ measurement tools and had small samples. Grey literature was not screened. Conclusion: Genetic overlap between SSD and IQ supports the neurodevelopmental hypothesis of schizophrenia. Most of the risk polymorphisms identified were in genes relevant to brain development, neural proliferation and differentiation, and synaptic plasticity.

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Verbal memory improvement in first-episode psychosis <em>APOE-</em>ε4 carriers: a pleiotropic effect?

Cited by 6 publications

References 56 publications

Association between cognitive impairment and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia

Association between cognitive impairment and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia

Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review

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