Verbal memory impairment in healthy siblings of patients with schizophrenia

Massuda, Raffael; Bücker, Joana; Czepielewski, Letícia Sanguinetti; Narvaez, Joana Corrêa de Magalhães; Pedrini, Mariana; Santos, Bárbara Tietbohl Martins Quadros dos; Teixeira, Ângelo Wander Ferreira; Souza, Ana Laura Germano De; Vasconcelos-Moreno, Mirela Paiva; Vianna-Sulzbach, Miréia; Goi, Pedro Domingues; Belmonte-de-Abreu, Paulo; Gama, Clarissa Severino

doi:10.1016/j.schres.2013.08.019

Cited by 17 publications

(12 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 60 In such context, verbal memory is among the most impaired cognitive domains in SCZ and unaffected siblings. 36 , 61 As expected, differences in cognitive performance between SCZ patients and HCs were observed for most tests used here.…”

Section: Discussionsupporting

confidence: 80%

Convergent evidences from human and animal studies implicate angiotensin I-converting enzyme activity in cognitive performance in schizophrenia

et al. 2015

View full text Add to dashboard Cite

In schizophrenia (SCZ), higher angiotensin I-converting enzyme (ACE) levels have been reported in patient's blood and cerebrospinal fluid (CSF). Hereby, we propose to explore whether the ACE activity levels are associated to cognitive performance in SCZ. Seventy-two patients with SCZ or schizoaffective disorder diagnosis, and 69 healthy controls (HCs) underwent a cognitive battery with parallel collection of peripheral blood samples to measure ACE activity. Significant higher ACE activity levels were confirmed in the plasma of SCZ patients compared with HCs (Student's t=−5.216; P<0.001). ACE activity significantly correlated to Hopkins delayed recall measures (r=−0.247; P=0.004) and Hopkins total (r=−0.214; P=0.012). Subjects grouped as high ACE activity (above average) had worse performance compared with low ACE activity level group for Hopkins delayed recall measure, even after correction for clinical condition, age, gender and years of education (P=0.029). The adjusted R squared for this final model was 0.343. This result was evident only comparing extreme groups for ACE activity, when splitting the sample in three groups with similar number of subjects. To clarify this finding, we performed an evaluation of the cognitive performance of transgenic mice with three copies of ACE gene in novel object recognition (NOR) test, which showed that such animals presented impairment in NOR (P<0.05) compared with two copies of wild-type animals. The results observed in SCZ patients and animal model suggest both the association of ACE to cognitive deficits in SCZ. This finding may support the evaluation of novel treatment protocols and/or of innovative drugs for specific intervention of cognitive deficits in SCZ envisioning concomitant ACE activity and behavior evaluations.

show abstract

Section: Discussionsupporting

confidence: 80%

Convergent evidences from human and animal studies implicate angiotensin I-converting enzyme activity in cognitive performance in schizophrenia

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Alterations in EVM have also been described in SB [36]. However, they showed a heterogeneous cognitive profile, ranging from deficits similar to those in SZ to cognitive performance analogous to HC [37].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Cytokines and Verbal Memory in Individuals with Schizophrenia and Their Unaffected Siblings

Rebouças

Rabelo‐da‐Ponte

Massuda

et al. 2018

Neuroimmunomodulation

View full text Add to dashboard Cite

Background: Verbal memory impairment may be considered an endophenotype in schizophrenia (SZ), also affecting the siblings of SZ subjects. Furthermore, the immune-inflammatory system response has an important modulatory effect on brain processes, especially on memory circuits. Objective: Investigating the relationship between TNF-α and IL-6 and memory performance in patients with SZ, their unaffected siblings (SB) and healthy controls (HC). Methods: 35 subjects with SZ, 36 SB, and 47 HC underwent a neurocognitive assessment for verbal memory by means of the revised Hopkins Verbal Learning Test (HVLT-R) in addition to serum cytokines analyses. Results: SZ patients performed worse in HVLT-R than SB and HC, but SB and HC were not different. Regarding the biomarker levels, we found significant results of TNF-α for both groups. However, we did not find differences between groups after multiple-comparisons analysis. There were no significant correlations between episodic verbal memory, TNF-α, and IL-6. Conclusion: The results are compatible with the hypothesis that deficits in verbal memory of individuals with SZ could be secondary to inadequate functioning of cognitive processing areas, such as proactive cognitive control.

show abstract

“…However, to date, few studies of SZ endophenotype have focused on neurocognitive functions. Prior studies have found deficits in executive function (Trail Making Test) (Aydin et al, 2017 ), memory (working memory (de Leeuw et al, 2013 ) and declarative memory (Trandafir et al, 2006 ) and attention (Massuda et al, 2013 ). However, the basic nature of the visual characteristics of siblings is unclear, especially in terms of binocular competition.…”

Section: Introductionmentioning

confidence: 98%

Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia

Xiao

Chen

et al. 2018

Front. Neurosci.

View full text Add to dashboard Cite

Objectives: Binocular rivalry is a typical example of bistable perception that arises when two monocular images are simultaneously presented to each eye. Binocular rivalry is a heritable perceptual cognitive function that is impaired in patients with schizophrenia (SZ). Despite its potential suitability as a visual endophenotype, binocular rivalry has hardly been studied in the unaffected siblings of schizophrenia (SIB). There is also little research about whether binocular rivalry is a potential visual endophenotype between SZ and SIB.Methods: In our cross-sectional study, we included 40 SZ and their unaffected SIBs, as well as 40 age- and sex-matched healthy controls (HC). All subjects underwent the binocular rivalry test, the Positive and Negative Syndrome Scale (PANSS) and a battery of cognitive neuropsychological assessments evaluating attention, memory and executive function domains.Results: Our results demonstrate that the switching rate in SZ was significantly slower than in HC (p < 0.001), and compared to the SIB, the mean alternation rates were significantly different (p < 0.01). Moreover, there was a significant difference in mean switching rate between the SIB and the HC (p < 0.001). There was no significant correlation between the alternation rate of binocular rivalry and these cognitive tasks and the PANSS scores.Conclusion: The present study shows that SZ and SIB both exhibit changes in binocular rivalry, with SIB exhibiting intermediate performance compared with that of SZ and the HC. This supports the claim that the switching rate for SZ differs from that of SIB and suggests that binocular rivalry may qualify as a visual endophenotype for SZ.

show abstract

Verbal memory impairment in healthy siblings of patients with schizophrenia

Cited by 17 publications

References 26 publications

Convergent evidences from human and animal studies implicate angiotensin I-converting enzyme activity in cognitive performance in schizophrenia

Convergent evidences from human and animal studies implicate angiotensin I-converting enzyme activity in cognitive performance in schizophrenia

The Relationship between Cytokines and Verbal Memory in Individuals with Schizophrenia and Their Unaffected Siblings

Slow Binocular Rivalry as a Potential Endophenotype of Schizophrenia

Contact Info

Product

Resources

About