Verbal memory impairment after left insular cortex infarction

Manes, Facundo; Springer, Jane A.; Jorge, Ricardo E.; Robinson, Robert G.

doi:10.1136/jnnp.67.4.532

Cited by 47 publications

(26 citation statements)

References 14 publications

(10 reference statements)

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“…Thus lesions to, or reductions in, insula volume may be associated with memory impairment. Such memory impairment has been described by Manes et al [45], who showed that individuals with left insula lesions had significantly poorer performances on verbal memory tasks than those with right insula lesions. Chen et al [46] conducted a study on victims of a fire disaster comparing 12 survivors with PTSD with 12 matched survivors without PTSD.…”

Section: Discussionmentioning

confidence: 83%

Relationship between Neurocognition and Regional Brain Volumes in Traumatized Adolescents with and without Posttraumatic Stress Disorder

Ahmed

Spottiswoode²,

Carey³

et al. 2012

Neuropsychobiology

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Objectives: Studies using convergent neurocognitive and structural imaging paradigms in adolescent posttraumatic stress disorder (PTSD) are limited; in the current study we used both voxel-based morphometry (VBM) to obtain between-group volumetric differences, and Freesurfer to examine the relationship between cognition and regional brain volumes. Methods: Participants were 21 traumatized adolescents with PTSD matched with 32 traumatized adolescents without PTSD. Magnetic resonance images were obtained on a 1.5-Tesla MAGNETOM Siemens Symphony scanner. VBM implemented on FSL was then used to compare between-group grey matter volumes, after which Freesurfer was used to obtain global volume and thickness measurements in different brain regions. Results: Significant between-group neurocognitive differences were found for tests of attention, delayed recall and visual reconstruction. On VBM, reduced grey matter was found in three regions in the PTSD group: left insula, right precuneus and right cingulate gyrus, using uncorrected values (p < 0.001), while no statistically significant between-group differences were found on the initial Freesurfer stream. Further Freesurfer analysis on Qdec revealed significant reductions in the insula for the PTSD group. In addition, volumetric changes in the corpus callosum and insula were significantly associated with deficits in logical memory and visual reproduction on Freesurfer analysis. Conclusions: Trauma exposure of itself may be sufficient to cause structural changes in adolescents regardless of PTSD development.

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Section: Discussionmentioning

confidence: 83%

Relationship between Neurocognition and Regional Brain Volumes in Traumatized Adolescents with and without Posttraumatic Stress Disorder

Ahmed

Spottiswoode²,

Carey³

et al. 2012

Neuropsychobiology

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show abstract

“…In addition, the line bisection task was applied to report unilateral visual neglect. Right insular lesion patients showed grater severity of neglect over the somesthetic, visual, and auditory perception, when compared with left insular damage (see also Manes et al 1999c). In contrast, left-insular lesion patients presented small measures of neglect in the auditory modality.…”

Section: Neglectmentioning

confidence: 97%

“…Manes et al (1999c) compared verbal profiles between a group of four patients with right insular lesion and another with six patients with left insular lesions. Only patients who had performed within normal limits in measures of naming, word association, IQ, visual domain, and mental state were included in the study.…”

Section: Languagementioning

confidence: 99%

Clinical effects of insular damage in humans

2010

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Multiple disturbances following lesions of the insula are reviewed in the present article, including those related to autonomic function; gustatory, olfactory, auditory, somatosensory, and multimodal perception, as well as body awareness; the emotion of disgust; mood and willed action, addiction behavior, and language. Given the multiple and varied nature of the impairments revealed by lesion studies, we suggest that the insula, as a multimodal area, has a major role as a convergence zone implicated in the coordination between internal and external information through emotional subjective awareness. Methodological issues are discussed with attention paid to lesion etiology, and lesions involving adjacent areas to the insular cortex.

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“…Thus, it is well positioned anatomically to play a crucial role in neural networks involved in verbal communication. Damage to the insula has been proposed as one of the possible neural substrates of conduction aphasia (Damasio & Damasio, 1980), apraxia of speech (Dronkers, 1996), auditory agnosia (Habib et al, 1995), dyslexia (Paulesu et al, 1996), and verbal memory (Manes, Springer, Jorge, & Robinson, 1999). Previous neuroimaging studies have implicated insular cortex in tasks involving articulation and speech coordination (Wise, Greene, Buchel, & Scott, 1999), short-term verbal memory (Paulesu et al, 1993), and music (Zatorre et al, 1994).…”

Section: Revising the Classic Model Of Language Localizationmentioning

confidence: 98%

Functional Heterogeneity of Inferior Frontal Gyrus Is Shaped by Linguistic Experience

Hsieh¹,

Gandour²,

Wong

et al. 2001

Brain and Language

147

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Verbal memory impairment after left insular cortex infarction

Abstract: The findings suggest that the insula may be part of a functional network that mediates verbal memory. (J Neurol Neurosurg Psychiatry 1999;67:532-534)

Cited by 47 publications

References 14 publications

Relationship between Neurocognition and Regional Brain Volumes in Traumatized Adolescents with and without Posttraumatic Stress Disorder

Relationship between Neurocognition and Regional Brain Volumes in Traumatized Adolescents with and without Posttraumatic Stress Disorder

Clinical effects of insular damage in humans

Functional Heterogeneity of Inferior Frontal Gyrus Is Shaped by Linguistic Experience

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