Verbal memory declines more in female patients with Parkinson's disease: the importance of gender-corrected normative data

Fengler, Sophie; Roeske, Sandra; Heber, Ines Ann; Reetz, Kathrin; Schulz, Jörg B.; Riedel, Oliver; Wittchen, Hans‐Ulrich; Storch, Alexander; Linse, Katharina; Baudrexel, Simon; Hilker, Rüdiger; Mollenhauer, Brit; Witt, Karsten; Schmidt, Nele; Balzer‐Geldsetzer, Monika; Dams, Judith; Dodel, Richard; Gräber, Susanne; Padovani, Alessandro; Petrelli, A.; Fünkele, S.; Kassubek, Jan; Kalbe, Elke

doi:10.1017/s0033291716000908

Cited by 18 publications

(8 citation statements)

References 70 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sex differences in cognition was inconsistent. Some studies found male sex were at risk, but others found female sex [3,8,26,27]. We also found that male sex among LRRK2 G2385R non-carriers had a tendency to develop cognitive impairment.…”

Section: The Effect Of Sex On Clinical Profile In Lrrk2 G2385r Carriers and Non-carrierssupporting

confidence: 51%

Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

Cui

et al. 2021

BMC Neurosci

View full text Add to dashboard Cite

Background Differences of genotypes between male and female have been studied in Parkinson’s disease (PD), but limited research has focused on the comparison between sexes with LRRK2 G2385 variant. Objective The aim of this study was to explore sex effects in the same genetic subtype and role of leucine-rich repeat kinase 2 (LRRK2) G2385R variants in the same sex in PD. Methods 613 PD patients were recruited from the Movement Disorders Clinic in Ruijin Hospital. We did not include healthy controls in this study. The data collected includes demographic information, disease history, scores of motor and non-motor symptoms scales, midbrain transcranial sonography and DNA. Binary logistic regression analysis was performed to evaluate the association between clinical features and sex in LRRK2 G2385R carriers and non-carriers, as well as the association between the clinical features and LRRK2 G2385R variants in male and female sex. Results Sex distribution is similar in LRRK2 G2385R carriers and non-carriers. In male sex, LRRK2 G2385R carriers showed lower risk in cognitive impairment compared with non-carriers (OR = 0.301, p = 0.003, 95%CI 0.135–0.668). In female sex, LRRK2 G2385R carriers showed lower risk in autonomic dysfunction compared with non-carrier (OR = 0.401, p = 0.040, 95%CI 0.167–0.960). In LRRK2 G2385R non-carriers, female sex showed lower risk of impairment in activity of daily living (OR = 0.610, p = 0.021, 95%CI 0.400–0.928), excessive daytime sleepiness (OR = 0.555, p = 0.007, 95%CI 0.361–0.853), substantia nigra hyperechogenicity (OR = 0.448, p = 0.019, 95%CI 0.228–0.878), autonomic dysfunction frequency (OR = 0.626, p = 0.016, 95%CI 0.428–0.917) and higher risk in mood disorders (OR = 1.691, p = 0.022, 95%CI 1.078–2.654) compared with male. In LRRK2 G2385R carriers, female sex showed a lower risk of autonomic dysfunction (OR = 0.294, p = 0.024, 95%CI 0.102–0.849) compared with male. Conclusion In contrast to male PD patients, a more benign disease course was observed in female in both LRRK2 G2385R carriers and non-carriers. However, sex differences were less notable in PD with LRRK2 G2385R variants.

show abstract

Section: The Effect Of Sex On Clinical Profile In Lrrk2 G2385r Carriers and Non-carrierssupporting

confidence: 51%

Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

Cui

et al. 2021

BMC Neurosci

View full text Add to dashboard Cite

show abstract

“…Sex differences in cognition was inconsistent. Some studies found male were at risk, but others found female [3,8,26,27]. Male sex among LRRK2 G2385R non-carriers had a tendency to cognitive impairment in our study.…”

Section: The Effect Of Sex On Clinical Pro Le In Lrrk2 G2385r Carriercontrasting

confidence: 48%

Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

Cui

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Differences between male and female have been studied for PD but limited data was focused on the comparison between sexes with LRRK2 G2385 variant. Objective This study was to explore sex effects in the same genetic subtype and role of leucine-rich repeat kinase 2 (LRRK2) G2385R variants in the same sex. Methods 613 PD Patients were recruitment from Movement Disorders Clinic in Ruijin Hospital. Clinical data including demographic information, disease history, scales of motor and non-motor symptoms, midbrain transcranial sonography and DNA was collected. Binary logistic regression analysis was performed to evaluate the possible association between the clinical features and sex in LRRK2 G2385R carriers and non-carriers, and to evaluate the possible association between the clinical features and LRRK2 G2385R variants in male and female. Results Sex distribution is similar in LRRK2 G2385R carriers and non-carriers. In male sex, LRRK2 G2385R carriers showed lower risk in cognitive impairment compared with non-carriers (OR = 0.301, p = 0.003, 95%CI 0.135–0.668). In female sex, LRRK2 G2385R carriers showed lower risk in autonomic dysfunction compared with non-carrier (OR = 0.401, p = 0.040, 95%CI 0.167–0.960). In LRRK2 G2385R non-carriers, female showed lower risk of impairment in activity of daily living (OR = 0.610, P = 0.021, 95%CI 0.400-0.928), excessive daytime sleepiness (OR = 0.555, p = 0.007, 95%CI 0.361–0.853), substantia nigra hyperechogenicity (OR = 0.448, P = 0.019, 95%CI 0.228–0.878), autonomic dysfunction frequency (OR = 0.626, p = 0.016, 95%CI 0.428–0.917) and higher risk in mood disorders (OR = 1.691, p = 0.022, 95%CI (1.078–2.654) compared with male. In LRRK2 G2385R carriers, female showed a lower risk of autonomic dysfunction (OR = 0.294, p = 0.024, 95%CI 0.102–0.849) compared with male. Conclusion A more benign disease course was observed in female compared to male in both LRRK2 G2385R carriers and non-carriers. However, sex differences were less notable in PD with LRRK2 carriers.

show abstract

“…They explain advantages of elderly men in arithmetic and financial capabilities with employment in mathematics-related fields, higher level of education (paralleling generational effects) and mathematical interests. The arithmetic advantage for men is remarkable as gender effects usually dissociate from men showing stronger global cognitive decline but indicate differentiated visuo-spatial and verbal memory deficits in female PD patients (Fengler et al, 2016;Bakeberg et al, 2021). Therefore, the current association of visuo-spatial/constructional functions and story memory with arithmetic deficits is in line with finding more arithmetic deficits in female patients.…”

Section: Phenotyping Arithmetic Errors In Financial Contexts In Pd (H2)mentioning

confidence: 60%

Arithmetic Errors in Financial Contexts in Parkinson’s Disease

et al. 2021

View full text Add to dashboard Cite

Research on dyscalculia in neurodegenerative diseases is still scarce, despite high impact on patients’ independence and activities of daily living function. Most studies address Alzheimer’s Disease; however, patients with Parkinson’s Disease (PD) also have a higher risk for cognitive impairment while the relation to arithmetic deficits in financial contexts has rarely been studied. Therefore, the current exploratory study investigates deficits in two simple arithmetic tasks in financial contexts administered within the Clinical Dementia Rating in a sample of 100 PD patients. Patients were classified as cognitively normal (PD-NC) or mildly impaired (PD-MCI) according to Level I consensus criteria, and assessed using a comprehensive neuropsychological test battery, neurological motor examination, and sociodemographic and clinical questionnaires. In total, 18% showed arithmetic deficits: they were predominately female, had longer disease duration, more impaired global cognition, but minor signs of depression compared to PD patients without arithmetic deficits. When correcting for clinical and sociodemographic confounders, greater impairments in attention and visuo-spatial/constructional domains predicted occurrence of arithmetic deficits. The type of deficit did not seem to be arbitrary but seemed to involve impaired place × value processing frequently. Our results argue for the importance of further systematic investigations of arithmetic deficits in PD with sensitive tests to confirm the results of our exploratory study that a specific subgroup of PD patients present themselves with dyscalculia.

show abstract

Verbal memory declines more in female patients with Parkinson's disease: the importance of gender-corrected normative data

Cited by 18 publications

References 70 publications

Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

Arithmetic Errors in Financial Contexts in Parkinson’s Disease

Contact Info

Product

Resources

About