Verbal memory and 5-HT1A receptors in healthy volunteers – A PET study with [carbonyl-11C]WAY-100635

Penttilä, Jani; Hirvonen, Jussi; Tuominen, Lauri; Lumme, Ville; Ilonen, Tuula; Någren, Kjell; Hietala, Jarmo

doi:10.1016/j.euroneuro.2015.12.028

Cited by 13 publications

(5 citation statements)

References 27 publications

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“…We also found group differences in educational achievement; it is conceivable that group differences may also have been observed if IQ data had been available for all subjects. Future studies should endeavor to include IQ as a measure in PET studies of antisocial offenders, given that components of the endocannabinoid system may be linked to IQ, as has been shown for serotonin levels and cognition 67 , 68 . Finally, our sample of ASPD participants were all convicted of their violent crimes and, therefore, may differ in important ways from other ASPD individuals who offend but successfully evade the law.…”

Section: Discussionmentioning

confidence: 99%

Lower amygdala fatty acid amide hydrolase in violent offenders with antisocial personality disorder: an [11C]CURB positron emission tomography study

et al. 2021

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Antisocial personality disorder (ASPD) imposes a high societal burden given the repetitive reactive aggression that affected individuals perpetrate. Since the brain endocannabinoid system (ECS) has been implicated in ASPD and aggressive behavior, we utilized [11C]CURB positron emission tomography to investigate fatty acid amide hydrolase (FAAH), an enzyme of the ECS that degrades anandamide, in 16 individuals with ASPD and 16 control participants. We hypothesized that FAAH density would be lower in the amygdala for several reasons. First, decreased FAAH expression is associated with increased cannabinoid receptor 1 stimulation, which may be responsible for amygdala hyper-reactivity in reactive aggression. Second, the amygdala is the seat of the neural circuit mediating reactive aggression. Third, other PET studies of externalizing populations show reduced brain FAAH density. Conversely, we hypothesized that FAAH expression would be greater in the orbitofrontal cortex. Consistent with our hypothesis, we found that amygdala FAAH density was lower in the amygdala of ASPD (p = 0.013). Cerebellar and striatal FAAH expression were inversely related with impulsivity (cerebellum: r = −0.60, p = 0.017; dorsal caudate: r = −0.58, p = 0.023; dorsal putamen: r = −0.55, p = 0.034), while cerebellar FAAH density was also negatively associated with assaultive aggression (r = −0.54, p = 0.035). ASPD presents high levels of disruptive behavior with few, if any, efficacious treatment options. Novel therapeutics that increase FAAH brain levels in a region-specific manner could hold promise for attenuating certain symptom clusters of ASPD, although our results require replication.

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Section: Discussionmentioning

confidence: 99%

Lower amygdala fatty acid amide hydrolase in violent offenders with antisocial personality disorder: an [11C]CURB positron emission tomography study

et al. 2021

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“…Then, [carbonyl- 11 C]WAY-100635 was synthesized, which was degraded into polar radioactive metabolites that did not cross the BBB [ 21 , 22 ]. Since its first synthesis, [ carbonyl- 11 C ]WAY-100635 has become a reference radioligand, allowing several studies to be performed first on healthy patients and then on patients presenting several psychiatric conditions such as depression, anxiety, or anorexia [ 22 , 23 , 24 , 25 ]. Nevertheless, several pharmacomodulations have been performed in order to mainly reduce its metabolization, leading to the preparation of carbon-11 and fluorine-18 radioligands.…”

Section: 5-ht 1 Receptorsmentioning

confidence: 99%

Radiotracers for the Central Serotoninergic System

2022

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“…With regard to cognitive function in healthy subjects, Yasuno et al found a negative correlation between explicit memory function and 5-HT1A receptor availability in the hippocampus ( 58 ), while Borg et al, who performed [ 11 C]WAY100635 PET and used the same simplified reference model, found no correlation between regional 5-HT1A receptor availability in the raphe nuclei, hippocampus, and neocortex and various domains of cognitive performance ( 55 , 59 ). However, a recent study by Penttila et al found that global 5-HT1A receptor binding, measured with the gold standard method based on kinetic modeling using arterial blood samples, was positively correlated with measures of verbal memory in healthy subjects ( 60 ). To date, no 5-HT1A PET data have been reported for patients with schizophrenia in relation to cognitive function.…”

Section: Serotonin (5-hydroxytryptamine 5-ht)mentioning

confidence: 99%

Cognitive Function and Monoamine Neurotransmission in Schizophrenia: Evidence From Positron Emission Tomography Studies

Takano¹

2018

Front. Psychiatry

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Positron emission tomography (PET) is a non-invasive imaging technique used to assess various brain functions, including cerebral blood flow, glucose metabolism, and neurotransmission, in the living human brain. In particular, neurotransmission mediated by the monoamine neurotransmitters dopamine, serotonin, and norepinephrine, has been extensively examined using PET probes, which specifically bind to the monoamine receptors and transporters. This useful tool has revealed the pathophysiology of various psychiatric disorders, including schizophrenia, and the mechanisms of action of psychotropic drugs. Because monoamines are implicated in various cognitive processes such as memory and executive functions, some PET studies have directly investigated the associations between monoamine neurotransmission and cognitive functions in healthy individuals and patients with psychiatric disorders. In this mini review, I discuss the findings of PET studies that investigated monoamine neurotransmission under resting conditions, specifically focusing on cognitive functions in patients with schizophrenia. With regard to the dopaminergic system, some studies have examined the association of dopamine D1 and D2/D3 receptors, dopamine transporters, and dopamine synthesis capacity with various cognitive functions in schizophrenia. With regard to the serotonergic system, 5-HT1A and 5-HT2A receptors have been studied in the context of cognitive functions in schizophrenia. Although relatively few PET studies have examined cognitive functions in patients with psychiatric disorders, these approaches can provide useful information on enhancing cognitive functions by administering drugs that modulate monoamine transmission. Moreover, another paradigm of techniques such as those exploring the release of neurotransmitters and further development of radiotracers for novel targets are warranted.

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Verbal memory and 5-HT1A receptors in healthy volunteers – A PET study with [carbonyl-11C]WAY-100635

Cited by 13 publications

References 27 publications

Lower amygdala fatty acid amide hydrolase in violent offenders with antisocial personality disorder: an [11C]CURB positron emission tomography study

Lower amygdala fatty acid amide hydrolase in violent offenders with antisocial personality disorder: an [11C]CURB positron emission tomography study

Radiotracers for the Central Serotoninergic System

Cognitive Function and Monoamine Neurotransmission in Schizophrenia: Evidence From Positron Emission Tomography Studies

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