Verbal memory after temporal lobe epilepsy surgery in children: Do only mesial structures matter?

Law, Nicole; Benifla, Mony; Rutka, James T.; Smith, Mary Lou

doi:10.1111/epi.13635

Cited by 25 publications

(22 citation statements)

References 36 publications

(110 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Postoperative neuropsychology testing was not performed, this being a limitation of the study. A recent retrospective study showed a decrease in verbal memory in children following left temporal lobe surgery that includes mesial structures, particularly when language representation is in the left hemisphere [34]. Importantly, that study did not find a correlation between seizure freedom and postsurgical decline in verbal memory.…”

Section: Discussionmentioning

confidence: 83%

Temporal lobe surgery for intractable epilepsy in children: What to do with the hippocampus?

Benifla

Bennet-Back

Shorer

et al. 2017

Seizure

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 83%

Temporal lobe surgery for intractable epilepsy in children: What to do with the hippocampus?

Benifla

Bennet-Back

Shorer

et al. 2017

Seizure

Self Cite

View full text Add to dashboard Cite

show abstract

“…Better preoperative performance level and left‐sided (mesial) TL surgery have been shown to be associated with worse verbal memory outcomes in numerous studies; for example, Law et al compared 23 children who underwent TL surgery while sparing the mesial structures (TL) to 40 patients with temporal lobectomies that included resection of mesial structures (TL + M) regarding their memory and seizure outcomes. They found that greater declines were evident in children after TL + M resections within the language‐dominant hemisphere.…”

Section: Discussionmentioning

confidence: 99%

Effects of hippocampus‐sparing resections in the temporal lobe: Hippocampal atrophy is associated with a decline in memory performance

et al. 2020

View full text Add to dashboard Cite

Objective:In patients with temporal lobe epilepsy (TLE) with a nonlesional and nonepileptogenic hippocampus (HC), in order to preserve functionally intact brain tissue, the HC is not resected. However, some patients experience postoperative memory decline, possibly due to disruption of the extrahippocampal memory network and secondary hippocampal volume (HV) loss. The purpose of this study was to determine the extent of hippocampal atrophy ipsilateral and contralateral to the side of the surgery and its relation to memory outcomes. Methods: Hippocampal volume and verbal as well as visual memory performance were retrospectively examined in 55 patients (mean age ± standard deviation [SD] 30 ± 15 years, 25 female, 31 left) before and 5 months after surgery within the temporal lobe that spared the entire HC. HV was extracted based on prespecified templates, and resection volumes were also determined. Results: HV loss was found both ipsilateral and contralateral to the side of surgery (P < .001). Postoperative left HV loss was a significant predictor of postoperative verbal memory deterioration after left-sided surgery (P < .01). Together with the preoperative verbal memory performance, postoperative left HV explained almost 60% of the variance (P < .0001). However, right HV was not a clear predictor of visual memory performance. Larger resection volumes were associated with smaller postoperative HV, irrespective of side of surgery (left: P < .05, right: P < .01). Significance: A disruption of the memory network by any resection within the TL, especially within the language-dominant hemisphere, may lead to HC atrophy and memory decline. These findings may further improve the counseling of patients concerning their postoperative memory outcome before TL resections sparing the entire HC. |WAGNER Et Al.

show abstract

“…Thus, the neuropsychological profile in paediatric cases, particularly in younger children, may not yield lateralizing or localizing signs. In teenagers with temporal lobe foci, the patterns are more similar to those described in adults, and thus similar approaches for interpretation and analysis of risk are appropriate (Law et al, 2017). It can be challenging to identify test measures that are normed across a wide age range from early childhood to late adolescence, which further complicates the comparison of results at different ages and longitudinal assessment of surgical outcomes.…”

Section: Consideration Of Special Populations Childrenmentioning

confidence: 99%

Indications and expectations for neuropsychological assessment in epilepsy surgery in children and adults

Baxendale

Wilson

Baker

et al. 2019

Epileptic Disorders

View full text Add to dashboard Cite

In our first paper in this series ( Epilepsia 2015; 56(5): 674–681), we published recommendations for the indications and expectations for neuropsychological assessment in routine epilepsy care. This partner paper provides a comprehensive overview of the more specialist role of neuropsychological assessment in the pre and postoperative evaluation of epilepsy surgery patients. The paper is in two parts. The first part presents the framework for the mandatory role of neuropsychologists in the presurgical evaluation of epilepsy surgery candidates. A preoperative neuropsychological assessment should be comprised of standardised measures of cognitive function in addition to wider measures of behavioural and psychosocial function. The results from the presurgical assessment are used to: (1) establish a baseline against which change can be measured following surgery; (2) provide a collaborative contribution to seizure characterization, lateralization and localization; (3) provide evidence‐based predictions of cognitive risk associated with the proposed surgery; and (4) provide the evidence base for comprehensive preoperative counselling, including exploration of patient expectations of surgical treatment. The second part examines the critical role of the neuropsychologist in the evaluation of postoperative outcomes. Neuropsychological changes following surgery are dynamic and a comprehensive, long‐term assessment of these changes following surgery should form an integral part of the postoperative follow‐up. The special considerations with respect to pre and postoperative assessment when working with paediatric populations and those with an intellectual disability are also discussed. The paper provides a summary checklist for neuropsychological involvement throughout the epilepsy surgery process, based on the recommendations discussed.

show abstract

Verbal memory after temporal lobe epilepsy surgery in children: Do only mesial structures matter?

Cited by 25 publications

References 36 publications

Temporal lobe surgery for intractable epilepsy in children: What to do with the hippocampus?

Temporal lobe surgery for intractable epilepsy in children: What to do with the hippocampus?

Effects of hippocampus‐sparing resections in the temporal lobe: Hippocampal atrophy is associated with a decline in memory performance

Indications and expectations for neuropsychological assessment in epilepsy surgery in children and adults

Contact Info

Product

Resources

About