Verbal manipulations of learning expectancy do not enhance reconsolidation

Abstract

Objectives Pharmacological studies using propranolol suggest that if reactivation signals that new information will be learned (i.e., there is an expectation for learning) reconsolidation can be enhanced. We examined if the verbal instructions to expect new learning will enhance reconsolidation of fear memories using the post-retrieval extinction paradigm. Methods On day one, participants (n = 48) underwent differential fear conditioning to two images (CS+ and CS-). On day two, participants were randomly assigned to one of three groups; groups one and two had their memory for the CS+ reactivated (i.e., a single presentation of the CS+) 10 minutes prior to extinction, whereas group three did not have their memory reactivated but went right to extinction (no reactivation group). One reactivation group was told that they would learn something new about the images (expectation for learning group), and the other group was told that they would not learn anything new (no expectation for learning group). On day three, return of fear was measured following reinstatement (i.e., four shocks). Fear potentiated startle (FPS) and skin conductance response (SCR) were measured throughout. Results There was evidence of fear acquisition for participants for SCR but not FPS. With regards to reconsolidation, SCR increased for the CS+ and CS-in all groups from the end of extinction to the beginning of re-extinction (i.e., return of fear). For FPS, post-hoc tests conducted on the sub-group of participants showing fear learning showed that FPS remained stable in the two reactivation groups, but increased to the CS+, but not the CS- in the no reactivation group. Implications These findings suggest that a verbal manipulation of the expectation for learning may not be salient enough to enhance reconsolidation. Results are discussed in relation to theories on differences in between SCR, as a measure of cognitive awareness, and FPS, as a measure of fear.

Relevancia anátomo–funcional del núcleo amigdalino. Su fisiología, fisiopatología y orientaciones terapéuticas

“…3,4 La definición del sistema límbico ha evolucionado con el tiempo, pero la mayoría de las investigaciones realizadas indican su función primordial en el procesamiento afectivo accesorios. 5 Las estructuras comúnmente incluidas en el sistema límbico son el hipocampo, la circunvolución del cíngulo, la amígdala, los núcleos septales, el hipotálamo, el estriado ventral, el tegmento ventral y las regiones corticales prefrontales. El concepto de "sistema límbico mayor" implica el papel de la memoria y el afecto en la organización de la conducta para asegurar la supervivencia del organismo y la especie.…”