Verbal fluency in Parkinson’s disease patients on/off dopamine medication

Herrera, Elena; Cuetos, Fernando; Ribacoba, René

doi:10.1016/j.neuropsychologia.2012.09.016

Cited by 64 publications

(57 citation statements)

References 38 publications

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“…Taken together, our findings are in line with previous evidence for impaired organization of language output in parkinsonism (Petrova et al, 2016) but suggest a more specific limitation of verbal generation. Besides corroborating previous work showing reduced verbal fluency in parkinsonism (Herrera, Cuetos, & Ribacoba, 2012), the profiles of verbal adynamia exhibited by both our patient groups were broadly in keeping with the findings documented in previous detailed case studies of patients with PSP and dynamic aphasia (Esmonde et al, 1996; Robinson et al, 2006; Robinson et al, 2015). However, our study did not differentiate parkinsonian syndromes.…”

Section: Discussionsupporting

confidence: 92%

“…Our data in PDD are in line with prior evidence for dopaminergic modulation of other cognitive functions, including letter fluency, verb processing, and various extra-linguistic executive tasks (Costa, Peppe, Dell’Agnello, Caltagirone, & Carlesimo, 2009),(Herrera & Cuetos, 2012; Herrera et al, 2012). Our finding that verbal adynamic deficits go beyond word generation to the generation of connected speech (sentences) suggests that the extent of such deficits in PDD may have been under-recognized, particularly if the severity of any deficit is modified by dopaminergic therapy.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

Magdalinou¹,

Golden

Nicholas

et al. 2018

Neurocase

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Verbal adynamia (impaired language generation, as during conversation) has not been assessed systematically in parkinsonian disorders. We addressed this in patients with Parkinson’s dementia, progressive supranuclear palsy and corticobasal degeneration. All disease groups showed impaired verbal fluency and sentence generation versus healthy age-matched controls, after adjusting for general linguistic and executive factors. Dopaminergic stimulation in the Parkinson’s group selectively improved verbal generation versus other cognitive functions. Voxel-based morphometry identified left inferior frontal and posterior superior temporal cortical correlates of verbal generation performance. Verbal adynamia warrants further evaluation as an index of language network dysfunction and dopaminergic state in parkinsonian disorders.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

Magdalinou¹,

Golden

Nicholas

et al. 2018

Neurocase

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“…The results demonstrate that those PD patients who are off the dopamine medication generate fewer words than those PD patients who are on their medication. The frequency of words for PD patients who are either on or off medication is not significantly different; however, differences are significantly noticed between PD patients who are off medication and healthy control patients [9].…”

Section: Introductionmentioning

confidence: 74%

“…Earlier studies of causality of the motor cortex in the human brain relate to motor disturbance [8] and its relevance for PD patients [8]. The loss of dopamine in the frontal-striatal cortex for PD patients affects verbal processing and plays a significant role in functioning of lexico-semantic fluency [9]. In order to test this, PD patients performed a phonemic fluency where they are asked to generate a list of words that starts with a given letter, as well as provide words in semantic categories for semantic fluency [10].…”

Section: Introductionmentioning

confidence: 99%

Causality graph learning on cortical information flow in Parkinson's disease patients during behaviour tests

Almalaq

Dai

Zhang

et al. 2015

2015 49th Asilomar Conference on Signals, Systems and Computers

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Electroencephalographic (EEG) signals of the human brains represent electrical activities for a number of channels recorded over a the scalp. The main purpose of this paper is to investigate the interactions and causality of different parts of a brain using EEG signals recorded during a performance subjects of verbal fluency tasks. Subjects who have Parkinson's Disease (PD) have difficulties with mental tasks, such as switching between one behavior task and another. The behavior tasks include motor and phonemic fluency. This method uses verbal generation skills, activating different Broca's areas of the Brodmann's areas (BA44 and BA45). Advanced signal processing techniques are used in order to determine the activated frequency bands in the granger causality for verbal fluency tasks. The graph learning technique for channel strength is used to characterize the complex graph of Granger causality. Also, the support vector machine (SVM) method is used for training a classifier between two subjects with PD and two healthy controls. Neural data from the study was recorded at the Colorado Neurological Institute (CNI).

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“…Other measures were less sensitive; for example, our verbal fluency score detected impairment in 4 ndPD and 1 NC, with an effect size of .21. Studies of fluency impairment in nondemented PD patients are mixed, with studies reporting deficits in only letter fluency, others in only semantic fluency, others reporting deficits in both, and still others reporting no deficits; furthermore, these deficits can be affected by PD medication [15]. The reasons for the enhanced sensitivity of the Executive Composite are two-fold.…”

Section: Discussionmentioning

confidence: 99%

Sensitive measures of executive dysfunction in non-demented Parkinson's disease

Bott

Johnson

Schuff

et al. 2014

Parkinsonism & Related Disorders

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Background We examined the sensitivity of different executive function measures for detecting deficits in Parkinson’s disease patients without dementia. Methods Twenty-one non-demented PD subjects and 21 neurologically healthy controls were administered widely used clinical executive functioning measures as well as the NIH EXAMINER battery, which produces Cognitive Control, Working Memory, and Verbal Fluency scores, along with an overall Executive Composite score, using psychometrically matched scales. Results No significant differences between groups were observed on widely used clinical measures. The PD patients scored lower than controls on the EXAMINER Executive Composite, Cognitive Control, and Working Memory Scores. Conclusions The NIH EXAMINER Executive Composite and Cognitive Control Scores are sensitive measures of executive dysfunction in non-demented PD, and may be more sensitive than several widely used measures. Results highlight the importance of careful test selection when evaluating for mild cognitive impairment in PD.

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Verbal fluency in Parkinson’s disease patients on/off dopamine medication

Cited by 64 publications

References 38 publications

Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

Causality graph learning on cortical information flow in Parkinson's disease patients during behaviour tests

Sensitive measures of executive dysfunction in non-demented Parkinson's disease

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