Verarbeitung vestibulärer Impulse im Zentralnervensystem

Kisely, Mihály; Tóth, Attila; Emri, Miklós; Lengyel, Zsolt; Kálvin, Beáta; Horváth, Géza; Trón, Lajos; Bogner, Barna; Sziklai, István

doi:10.1007/s001060050761

Cited by 2 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Scientists relying on this technique have made efforts to guarantee experimental conditions under which the tactile, nociceptive, and possibly auditory components of CVS do not influence the results of the measurements, i.e., waiting for 10 s after the injection of cold water prior to the start of PET data acquisition (Bottini et al 1994(Bottini et al , 2001 or delaying the start of PET investigations by an average of 145 and 25 s following stimulation with cold water or warm air, respectively, in an effort ensure that the effect of fast-quenching activation due to mechanical and CVS is decreased (Wenzel et al 1996). In earlier experiments (Kisely et al 2001), we applied the technique of stimulation with icy water and found that this resulted in an expressed and prolonged sensation of cold and pain, which persisted during data acquisition. These observations immediately led to the question as to which of the components of the changes in rCBF induced by CVS stimulation could be attributed to the processing of vestibular signals and which were related to the pain or cold sensation.…”

Section: Discussionmentioning

confidence: 95%

“…The introduction of functional imaging into research relating to the processing of signals of the vestibular system proved to be a breakthrough (Bense et al 2001;Bottini et al 1994Bottini et al 1995Bottini et al , 2001Brandt et al 1998Brandt et al , 2002Kisely et al 2001;Lobel et al 1998Lobel et al 1999Ö dkvist et al 1974;Paulesu et al 1997;Penfield 1957;Takeda et al 1996). These techniques are suitable for studies of the regional blood flow in the CNS, which are effective in the localization of different cerebral functions.…”

Section: Discussionmentioning

confidence: 99%

“…CVS was performed by the injection of 30 ml of water (0°C) in 60 s into the external acoustic meatus (Bottini et al 1994(Bottini et al , 2001Kisely et al 2001). To ensure standard conditions, the injection was always performed with a Braun perfusion pump.…”

Section: Caloric Stimulationmentioning

confidence: 99%

“…The most widely used examination techniques in which stimulation is applied involve optokinetic, galvanic, and caloric vestibular stimulation (CVS) and the neck vibration (NV) test (Bense et al 2001;Bottini et al 1994Bottini et al 2001Bucher et al 1998;Kisely et al 2001;Lobel et al 1998Lobel et al 1999Paulesu et al 1997). The various authors agree that any technique of stimulation will affect more than one modality.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cortical Projection of Peripheral Vestibular Signaling

Emri

Kisely

Lengyel

et al. 2003

Journal of Neurophysiology

View full text Add to dashboard Cite

The cerebral projection of vestibular signaling was studied by using PET with a special differential experimental protocol. Caloric vestibular stimulation (CVS)-induced regional cerebral blood flow (rCBF) changes were investigated in two populations. Butanol perfusion scans were carried out on six healthy volunteers and on six patients following the removal of tumors from the right cerebello pontine angle. The complete loss of the vestibular function postoperatively allowed a comparison of the rCBF changes in the populations with or without this input and offered a promising functional approach whereby to delineate the cortical region most responsive to pure vestibular input. The activations by left-sided and right-sided CVS were determined for both the healthy volunteers and the patient population. Statistical analysis of the data obtained following left-sided CVS did not reveal any cerebral region for which there was a significant difference in CVS-induced response by these two populations. In the case of right-sided CVS, however, the statistical comparison of the CVS-related responses demonstrated a single contralateral area characterized by a significantly different degree of response. This cortical area corresponds to part of the cortical region described recently which can be activated by both CVS and neck vibration. It appears to be anatomically identical to the aggregate of the somatosensory area SII and the retroinsular cortex described in primates, a region identified by other investigators as an analog of the parietoinsular vestibular cortex.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Caloric Stimulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cortical Projection of Peripheral Vestibular Signaling

Emri

Kisely

Lengyel

et al. 2003

Journal of Neurophysiology

View full text Add to dashboard Cite

show abstract

Changes in brain activation caused by caloric stimulation in the case of cochleovestibular denervation - PET study

Kisely

Emri²,

Lengyel³

et al. 2002

Nuclear Medicine Communications

View full text Add to dashboard Cite

There are a number of well-known stimulation methods for the investigation of the central projection of the vestibular system. In addition to optokinetic, galvanic and neck vibration tests, the most widespread method is caloric stimulation. These listed methods cause not only vestibular, but also other effects on the central nervous system (CNS) (acoustic, tactile and nociceptive). In this paper, positron emission tomography (PET) was used to investigate whether caloric stimulation contains a non-vestibular (extravestibular) component, which would cause a distortion in the cortical activity and therefore in the vestibular effect on the CNS. Caloric stimulation was carried out in six patients who had been operated on due to cerebello-pontine angle tumour. These patients suffered post-operatively from a complete lesion of the vestibular system and anacusis on the operated side. Ipsilaterally activated areas were the inferior pole of the post-central gyrus and temporoparietal junction, caudal part of the post-central gyrus (SI, SII), inferior parietal lobule and medial frontal gyrus. Contralaterally activated areas were the anterior cingulate gyrus, medial frontal gyrus, posterior part of the insula, post-central gyrus and temporoparietal junction (SII). Ipsilaterally deactivated areas were the caudal and cranial part of the medial occipital gyrus (V2, V3, V4, V5). Contralaterally deactivated areas were the lingual gyrus, inferior occipital gyrus (V2, V3) and fusiform gyrus. On the basis of these data, it was postulated that, during caloric stimulation, extravestibular reaction also occurs, which corresponds to the subjective feeling of heat and pain. The deactivation of the occipital cortex due to an extravestibular effect was demonstrated. This is the first observation to suggest the possibility of nociceptivevisual interaction.

show abstract

Verarbeitung vestibulärer Impulse im Zentralnervensystem

Abstract: We are the first to point out the functional connection between the hippocampus and the vestibular system in this report.

Cited by 2 publications

References 14 publications

Cortical Projection of Peripheral Vestibular Signaling

Cortical Projection of Peripheral Vestibular Signaling

Changes in brain activation caused by caloric stimulation in the case of cochleovestibular denervation - PET study

Contact Info

Product

Resources

About