Veränderungen im Bereich der Mittelohrschleimhaut bei der Otosklerose

Arnold, W.

doi:10.3109/00016487609119948

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…It begins with lacunary resorption of the bone by the proliferating active connective tissue of the vessels, probably from the mucosa of the tympanic cavity in the region of the stapes footplate. In the course of this process thickening or the vascular basement membrane and endothelial oedema is observed; some vessels show features of obliteration and fibroblasts of the vascular connective tissue are converted into functional osteoclasts (Arnold and Plester, 1974, 1975, 1977Arnold, 1976). The mechanism triggering the osteolytic process of the proliferation of the osteoclasts is unclear (Holtrop et al, 1978).…”

Section: Introductionmentioning

confidence: 99%

“…Nucleocapsids resembling the measles virus have been noted under the electron microscope in osteocyte-like cells in the vascular spaces of the otosclerotic lesion (McKenna et al, 1986). Deposits of IgG and IgA were found in the enchondral zone of ossification and immunohistochemical tests have determined the expression of measles and rubella antigens in otosclerotic lesions (Arnold andFriedmann, 1987, Lim etal., 1987).…”

Section: Introductionmentioning

confidence: 99%

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Otosclerosis—an inflammatory disease of the otic capsule of viral aetiology?

Arnold

Friedmann

1988

J. Laryngol. Otol.

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Fragments of otospongiotic and otosclerotic footplates were investigated by immunohistochemical methods. Antibodies IgG, IgA, IgM were found to be bound to the vascular connective tissue of the resorption lacunae, IgG also to osteocytes. The application of antibodies against mumps, measles and rubella antigens showed the expression of the relevant viral antigens in the large cells of the resorption lacunae, in the vascular connective tissue, and in osteocytes, osteoclasts and chondrocytes, present in or around the otospongiotic areas. In the sclerotic stage only the perivascular connective tissue and chondrocytes have expressed viral antigens whereas IgG was restricted to the osteocytes of the sclerotic focus and to the residual perivascular tissue. Two footplates with postinflammatory sclerosis serving as controls revealed only IgG in some chondrocytes. Healthy footplates showed neither a deposition of antibodies nor any expression of viral antigens. These results favour a viral aetiology of otosclerosis as an inflammatory vascular reaction of the otic capsule initiated or caused by the viruses of measles, rubella and mumps.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Otosclerosis—an inflammatory disease of the otic capsule of viral aetiology?

Arnold

Friedmann

1988

J. Laryngol. Otol.

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Ohr

Schätzle¹

1984

Pathologie

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A Contribution to the pathogenesis of otosclerosis

Mann¹,

Jonas

Riede

et al. 1980

Arch Otorhinolaryngol

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In a histochemical and electron microscopical study the pathogenesis of otosclerosis was investigated. The morphological changes in the extra- and intracellular space indicated a complex metabolic disturbance of all tissue components. The observed chondrocytic chondrolysis stressed the role of the cartilage remnants in the otic capsule as an etiological factor. There was morphological evidence of a superimposed enzymatic defect.

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Veränderungen im Bereich der Mittelohrschleimhaut bei der Otosklerose

Cited by 7 publications

References 13 publications

Otosclerosis—an inflammatory disease of the otic capsule of viral aetiology?

Otosclerosis—an inflammatory disease of the otic capsule of viral aetiology?

Ohr

A Contribution to the pathogenesis of otosclerosis

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