Veränderungen der Lungenfunktion bei experimentell erzeugtem Emphysem vor und nach einseitiger Lungenhomotransplantation am Hund

SalemII, G.; Schlick, W; Keiler, A; Möschl, P; Glöckler, Martin; Göber, I; Radaszkiewicz, T.; Szalay, S; Kreuzer, W.

doi:10.1007/978-3-642-67895-0_5

Cited by 1 publication

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1), with an increase of hysteresis of the lung measured from pressure volume diagrams, an increase in functional residual capacity (FRC), and a slight increase (in some animals, a marked increase) in airway resistance when forced ventilation was performed by a respirator. We have previously described these changes in detail [5][6][7].…”

Section: Resultsmentioning

confidence: 99%

“…To achieve this, we produced experimental emphysema in dogs by intratracheal instillation of the proteolytic enzyme papain. We have described the technique and the methods of studying pulmonary function previously [5][6][7]. We observed the development of emphysema by pulmonary function tests which were done at weekly intervals.…”

Section: Methodsmentioning

confidence: 99%

“…However, to date, the results of lung transplantation in patients with emphysema have been poor, with the exception of one 53-year-old man with massive emphysema who survived 6 months. Some authors [1, Presented at the XXVIIth Congress of the Socirt6 Internationale de Chirurgie, Kyoto, Japan, September [3][4][5][6][7][8]1977.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Allotransplantation of the lung in dogs with experimental lung damage

et al. 1979

View full text Add to dashboard Cite

In 8 dogs, bilateral pulmonary emphysema was induced by intratracheal instillations of papain, and in 6 dogs, unilateral emphysema was induced by bronchoscopic instillation of papain in the right main bronchus. Development of emphysema was documented by weekly pulmonary function studies. Lung compliance and functional residual capacity were increased, and airway resistance was increased in forced ventilation. When emphysema was established, unilateral allotransplantation of the lung was performed. Postoperative studies of lung function showed no serious ventilation-perfusion imbalance. Ventilatory function and oxygen consumption of the graft were at least equal to the animal's own damaged lung. Respiratory insufficiency and death were always accompanied by rejection or severe infection. It is concluded that postoperative respiratory failure was not due to difference of airway and vascular resistance between the damaged lung and the graft.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%