Ventromedial medullary pathway mediating cardiac responses evoked from periaqueductal gray

Moraes, Gean C A; Mendonça, Michelle Mendanha; Mourão, Aline A.; Graziani, Daniel; Pinto, Mauro Cunha Xavier; Ferreira, Patrícia; Pedrino, Gustavo Rodrigues; Fontes, M.A.P.; Oliveira‐Lima, Onésia Cristina; Xavier, Carlos Henrique

doi:10.1016/j.autneu.2020.102716

Cited by 6 publications

(6 citation statements)

References 62 publications

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“…This finding supports the modulation of medullary baroreflex circuitry by supramedullary regions within the midbrain and diencephalon [67]. These regions are recruited during emotional/psychological stresses [33,68] to provide excitatory inputs into the rostral ventromedial [62] and ventrolateral medullary neurons regulating heart and vasomotion [50,68]. These overactivated central regions express a2-adrenoreceptors and I1 imidazoline receptors, which are targets for the centrally acting antihypertensives [69,70] being assessed in the present study.…”

Section: Discussionsupporting

confidence: 84%

“…Hence, a more intense stimulus of an air-jet may recruit other areas besides those controlling vasomotion [58]. Since inhibition of raphe pallidus neurons, comprised within rostral ventromedial medulla, attenuates the tachycardia induced by air-jet [59], by hypothalamic [60,61] and midbrain stimulations [62], it is worth hypothesizing the modulation of cardiac sympathetic premotor neurons of raphe pallidus by centrally acting drugs. This hypothesis is supported by the study of Madden and coworkers, which showed attenuation of hypothalamic stimulation-induced tachycardia by CL injection into raphe regions [63].…”

Section: Discussionmentioning

confidence: 99%

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Centrally acting antihypertensives change the psychogenic cardiovascular reactivity

Mendonça

Costa

Moraes

et al. 2021

Fundamemntal Clinical Pharma

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Clonidine (CL) and Rilmenidine (RI) are among the most frequently prescribed centrally acting antihypertensives. Here, we compared CL and RI effects on psychogenic cardiovascular reactivity to sonant, luminous, motosensory, and vibrotactile stimuli during neurogenic hypertension. The femoral artery and vein of Wistar (WT – normotensive) and spontaneously hypertensive rats (SHR) were catheterized before (24 h interval) i.p. injection of vehicle (NaCl 0.9%, control ‐ CT group), CL (10 µg/kg), or RI (10 µg/kg) and acute exposure to luminous (5000 lm), sonant (75 dB sudden tap), motor (180° cage twist), and air‐jet (10 L/min – restraint and vibrotactile). Findings showed that: (i) CL or RI reduced the arterial pressure of SHR, without affecting basal heart rate in WT and SHR; (ii) different stimuli evoked pressor and tachycardic responses; (iii) CL and RI reduced pressor response to sound; (iv) CL or RI reduced pressor responses to luminous stimulus without a change in peak tachycardia in SHR; (v) cage twist increased blood pressure in SHR, which was attenuated by CL or RI; (vi) air‐jet increased pressure and heart rate; (vii) CL or RI attenuated the pressor responses to air‐jet in SHR while RI reduced the chronotropic reactivity in both strains. Altogether, both antihypertensives relieved the psychogenic cardiovascular responses to different stimuli. The RI elicited higher cardioprotective effects through a reduction in air‐jet‐induced tachycardia.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Centrally acting antihypertensives change the psychogenic cardiovascular reactivity

Mendonça

Costa

Moraes

et al. 2021

Fundamemntal Clinical Pharma

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“…However, future experimental research is needed to confirm this hypothesis. In addition, it has been claimed that sympathetic activity is modulated by the bidirectional connection of PAG to the hypothalamus, specially DMH, 39,[45][46][47] and hence alterations in cardiovascular activity by NO may be innervated by indirect pathways such as the dmPAG-DMH-RVLM-spinal cord pathway.…”

Section: Discussionmentioning

confidence: 99%

The role of nitric oxide in the dorsomedial periaqueductal gray (dmPAG) column in cardiovascular responses in urethane‐anesthetized male rats

Najaftomaraei

Ghorbani

Rahimi

et al. 2022

Anim Models and Exp Med

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Background The dorsomedial periaqueductal gray (dmPAG) is a mesencephalic area and has numerous functions including cardiovascular regulation. Because nitric oxide (NO) is present in the dmPAG, here we investigate, the probable cardiovascular effect of NO in the dmPAG. Methods Five groups (n = 6 for each group) were used as follows: (1) control; (2) L‐NAME (NG‐nitro‐L‐arginine methyl ester, a NO synthase inhibitor, 90 nmol); (3) L‐arginine (L‐Arg, a precursor for NO, 60 nmol); (4) Sodium nitroprusside (SNP, a NO donor, 27 nmol); and (5) L‐Arg + L‐NAME. The cardiovascular parameters were recorded by a Power Lab device after cannulation of the femoral artery. Drugs were injected using a stereotaxic instrument. The changes (∆) in systolic blood pressure (SBP), mean arterial pressure (MAP), and heart rate (HR) were calculated at different times and compared to the control group. Results Microinjection of L‐NAME significantly increased ∆SBP, ∆MAP, and ∆HR more than saline (from p < 0.05 to p < 0.001). L‐Arg only significantly increased ∆HR (p < 0.05). In the L‐Arg + L‐NAME group, the above parameters also significantly increased (from p < 0.01 to p < 0.05) but not as significantly as with L‐NAME alone. Microinjection of SNP significantly decreased ∆SBP and ∆MAP more than in the control and L‐NAME groups (from p < 0.01 to p < 0.001), but ∆HR did not change significantly. Conclusion The results indicated that NO in dmPAG has an inhibitory effect on cardiovascular responses in anesthetized rats.

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“…Wird das laterale periaquäduktale Grau (PAG) stimuliert, so stellen sich Verteidigungsverhaltensreaktionen und eine Erhöhung der Herzleistung und des Blutdrucks ein [62]. Das periaquäduktale Grau sendet monosynaptische Projektionen zu Neuronen des Raphe pallidus (Raphe-Kerne im Hirnstamm) [63]. Das Raphe-pallidus-Neuron kontrolliert kardiale Antworten, die vom PAG evoziert werden [63].…”

Section: Rolle Der Behandlungsregionunclassified

“…Das periaquäduktale Grau sendet monosynaptische Projektionen zu Neuronen des Raphe pallidus (Raphe-Kerne im Hirnstamm) [63]. Das Raphe-pallidus-Neuron kontrolliert kardiale Antworten, die vom PAG evoziert werden [63]. Eine einmalige MTTe-Intervention scheint einen Einfluss auf die PAG-Aktivierung zu nehmen.…”

Section: Rolle Der Behandlungsregionunclassified

Manuelle Therapietechniken an der Wirbelsäule zur Stimulation des autonomen Nervensystems - ein Scoping Review

Rogan

Taeymans

Berger

et al. 2023

Sportverletz Sportschaden

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Zusammenfassung Hintergrund Physikalische Maßnahmen oder manualtherapeutische Techniken (MTTe) wie Mobilisationen, Manipulationen oder Weichteiltechniken führen zu einer Verbesserung des Metabolismus oder einer Senkung hypertoner Muskulatur und werden auch zur Balanceregulierung bei zentralnervösen Veränderungen des autonomen Nervensystems (ANS) eingesetzt. Bisher fehlen empirische Erkenntnisse über Wirkungsmechanismen und Reizorte von MTTe auf das ANS. Das Ziel dieses vorliegenden Scoping Reviews war es, einen Überblick zu geben über den Erkenntnisstand der Anwendung von MTTe auf diverse Niveaus der Wirbelsäule auf das ANS. Methode Als Grundlage für die Durchführung des Scoping Reviews dienten die Datenbanken CENTRAL, Osteopathic Research Web, PEDro und PubMed. Umfang und Inhalte der Literatur wurden dokumentiert. Die Ergebnisse der einbezogenen und herangezogenen Studien wurden in narrativer Weise zusammengefasst, wobei der Fokus auf den signifikantesten klinischen Aspekten lag. Ergebnisse Manipulationen, Mobilisationen, myofasziale Techniken und zervikale Traktionen wurden als MTTe definiert. In 27 von 35 Studien wurden gesunde Probanden therapeutisch behandelt. Zehn Studien analysierten unmittelbare Effekte an Patienten, während 2 Studien als Longitudinalstudie bei Bluthochdruckpatienten konzipiert waren. In einem Zeitraum von 4–8 Wochen betrug die Interventionshäufigkeit wöchentlich zwischen einer und 3 MTTe-Einheiten. Schlussfolgerung Die Studienergebnisse erweisen sich als heterogen. Aus diesem Grund lassen sich keine verbindlichen, eindeutigen und allgemeingültigen Aussagen ableiten, in welcher Form, Intensität sowie in welchem Umfang MTTe angewendet werden sollen, um gezielt positive Wirkungsmechanismen am ANS in Gang zu setzen. Für zukünftige Studien sind demzufolge Longitudinalstudien mit Follow-up empfehlenswert. Darüber hinaus sollten umfassende Effekte von MTTe bei Patientengruppen mit unterschiedlichen Ausprägungen untersucht werden.

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Ventromedial medullary pathway mediating cardiac responses evoked from periaqueductal gray

Cited by 6 publications

References 62 publications

Centrally acting antihypertensives change the psychogenic cardiovascular reactivity

Centrally acting antihypertensives change the psychogenic cardiovascular reactivity

The role of nitric oxide in the dorsomedial periaqueductal gray (dmPAG) column in cardiovascular responses in urethane‐anesthetized male rats

Manuelle Therapietechniken an der Wirbelsäule zur Stimulation des autonomen Nervensystems - ein Scoping Review

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