Ventrolateral periaqueductal gray lesion attenuates nociception but does not change anxiety-like indices or fear-induced antinociception in mice

Mendes-Gomes, Joyce; Amaral, Vanessa Cristiane Santana; Nunes-de-Souza, Ricardo Luiz

doi:10.1016/j.bbr.2011.01.012

Cited by 19 publications

(19 citation statements)

References 60 publications

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“…Preclinical animal studies have also demonstrated that MS (maternal separation) rats exposed to WAS (water-avoidance stress) displayed an increased in activation of the S1, suggesting that stress in the adult MS rat results in enhanced sensory input to visceral noxious stimulation (Mendes-Gomes et al, 2011).…”

Section: Cortexmentioning

confidence: 99%

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Madasu

Okine

Olango

et al. 2016

Pharmacological Research

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Section: Cortexmentioning

confidence: 99%

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Madasu

Okine

Olango

et al. 2016

Pharmacological Research

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“…Some of these functions, for example descending modulation of pain, have been more clearly defined than others, but the putative functions all seem to play a homeostatic defense of the individual’s response, integrating afferent information from the periphery and information from higher centers. These functions may be segregated within the PAG (e.g., anxiety and pain (Mendes-Gomes et al, 2011)) based on current understandings of its anatomical subdivisions (see below). Conceptually the structure may be involved in balancing or segueing information related to survival salience.…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging of the periaqueductal gray: State of the field

et al. 2012

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This review and meta-analysis aims at summarizing and integrating the human neuroimaging studies that report periaqueductal gray (PAG) involvement; 250 original manuscripts on human neuroimaging of the PAG were identified. A narrative review and meta-analysis using activation likelihood estimates is included. Behaviors covered include pain and pain modulation, anxiety, bladder and bowel function and autonomic regulation. Methods include structural and functional magnetic resonance imaging, functional connectivity measures, diffusion weighted imaging and positron emission tomography. Human neuroimaging studies in healthy and clinical populations largely confirm the animal literature indicating that the PAG is involved in homeostatic regulation of salient functions such as pain, anxiety and autonomic function. Methodological concerns in the current literature, including resolution constraints, imaging artifacts and imprecise neuroanatomical labeling are discussed, and future directions are proposed. A general conclusion is that PAG neuroimaging is a field with enormous potential to translate animal data onto human behaviors, but with some growing pains that can and need to be addressed in order to add to our understanding of the neurobiology of this key region.

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“…In experiments carried out in our laboratory, sEPMexposed mice do not show marked antinociception, assessed with the formalin nociception test. Nevertheless, when mice are placed in a totally open elevated plus-maze (oEPM: with four open arms) a marked reduction in the time spent licking the formalin injected paw (i.e., antinociceptive response) is observed (Mendes-Gomes et al, 2011;Nunes-de-Souza, 2005, 2009). Given that the animals cannot avoid or escape the highly aversive open arms of the oEPM, this apparatus seems to be a more aversive situation than the sEPM.…”

Section: Introductionmentioning

confidence: 99%

Corticosterone does not change open elevated plus maze-induced antinociception in mice

Mendes-Gomes¹,

Miguel

Amaral

et al. 2011

Hormones and Behavior

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It has been demonstrated that the exposure of rodents to the standard elevated plus-maze (sEPM: 2 open and 2 enclosed arms) elicits defensive behavioral reactions and antinociception and also activates the hypothalamo-pituitary-adrenal (HPA) axis. We have recently reported that EPM-induced antinociception is particularly observed when rats and mice are exposed to a totally open EPM (oEPM: 4 open arms). Given that the oEPM seems to be a more aversive situation than the sEPM, we hypothesized that oEPM exposure would induce higher plasma levels of corticosterone than sEPM exposure in mice. In this study, we investigated the influence of exposure to eEPM (enclosed EPM: 4 enclosed arms), sEPM or oEPM on plasma corticosterone levels in mice, with or without prior nociceptive stimulation (2.5% formalin injection into the right hind paw). We also tested whether the nociceptive response in the formalin test and oEPM-induced antinociception are altered by adrenalectomy. Results showed that oEPM-exposed mice spent less time licking the injected paw than sEPM- and eEPM-exposed animals. All three types of EPM exposure increased plasma corticosterone when compared to the basal group, but sEPM- and oEPM-exposed mice showed higher corticosterone levels than eEPM-exposed mice. Prior nociceptive stimulation (formalin injection) did not enhance the plasma corticosterone response induced by the three types of EPM exposure. Indeed, formalin injection appeared to provoke a ceiling effect on plasma corticosterone concentration. Furthermore, neither the nociceptive response in the formalin test nor oEPM-induced antinociception was changed by adrenalectomy. Present results suggest that oEPM antinociception does not depend on corticosterone release in mice.

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Ventrolateral periaqueductal gray lesion attenuates nociception but does not change anxiety-like indices or fear-induced antinociception in mice

Cited by 19 publications

References 60 publications

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Neuroimaging of the periaqueductal gray: State of the field

Corticosterone does not change open elevated plus maze-induced antinociception in mice

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