Ventriculojugular shunt nephritis with Corynebacterium bovis

Bolton, W. Kline; Sande, Merle A.; Normansell, David E.; Sturgill, Benjamin C.; Westervelt, Frederic B.

doi:10.1016/0002-9343(75)90401-5

Cited by 49 publications

(24 citation statements)

References 10 publications

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“…The clinical picture in adult patients, as with ours, seems to be more benign. Shunt colonization did not produce symptoms in this patient, but this has been reported before; fever, for instance, can be absent [2,4,9,11,12,18,26], and blood cultures [6,14,18,[20][21][22]24] or CSF cultures [4, 5, 7, 9, 11-13, 17, 24, 25] can be sterile. In those instances the presence of shunt colonization can be proved by culturing the microorganism from the removed shunt system.…”

Section: Discussionsupporting

confidence: 62%

“…Shunt nephritis manifests itself months to years after insertion and colonisation [2], and many authors diagnosed the condition more than 3 years after operation, only partly due to unfamiliarity with the disease [2-7, 11, 12, 15, 16, 19-25], As Staphylococcus albus accounts for about 60% of shunt infections [28], this organism has been reported most often in association with shunt nephritis [1,2, 5-14, 17-26, 28], but Staphylococcus aureus [11,22], alpha-hemolytic streptococcus [18], micrococcus [25], Listeria monocyto genes [23] and Bacillus subtilis [28] have been described as well. Some authors isolated diphtheroids [15,16] as Corynebacterium bovis [4] and even Propionibacterium antes [3,6], which necessitated anaerobic culture of blood and CSF, as in our case.…”

Section: Discussionmentioning

confidence: 69%

“…Circulating immun complexes (detected with various techniques [4,7,11]), cryoglobulins [4,7,8,11,23,25] and rheumatoid factor [4,5,7,17,23] can be present in serum. Usually, but not always [6,11,12,14,18,20], various serum complement components, associated with activation by classical pathway, are depressed [2-11, 15-19, 22-26].…”

Section: Discussionmentioning

confidence: 99%

“…Staujfer and co-workers [20,21] were the first to use this term for a condition in which bacterial colonization of the ventriculo-atrial shunt is supposed to induce an immune complex glomerulonephritis. Very few adults with this dis ease have been described [3,4,6,7,[15][16][17]24,26], and some authors were able to demonstrate antigens of the associated microorganisms in the affected glomeruli by immuno fluorescence [4,5,8,16]. This has not been performed, how ever, in the 2 cases of shunt nephritis associated with Pro pionibacterium acnes published so far [3,6].…”

Section: Introductionmentioning

confidence: 99%

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Shunt Nephritis Associated with <i>Propionibacterium acnes</i> with Demonstration of the Antigen in the Glomeruli

Groeneveld¹,

Nommensen²,

Mullink

et al. 1982

Nephron

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A 27-year-old woman with a ventriculo-atrial shunt presented with a nephrotic syndrome and hypocomplementemia. Propionibacterium acnes was cultured from blood and shunt valve. The renal biopsy specimen showed features of membranoproliferative glomerulonephritis, and IgM, C3 and the bacterial antigen were demonstrated by immunofluorescence microscopy. Treatment resulted in slow resolution of the nephritis. A short review of the literature will be given.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Shunt Nephritis Associated with <i>Propionibacterium acnes</i> with Demonstration of the Antigen in the Glomeruli

Groeneveld¹,

Nommensen²,

Mullink

et al. 1982

Nephron

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“…IgM, IgE, Clq, C3, C4, fibrinogen, and alpha-2-macroglobulin (2). No fluorescent staining was seen in blood vessel walls.…”

mentioning

confidence: 90%

Spontaneous rupture of the liver

Levitin

Sweet

Brunner

et al. 1977

Arthritis & Rheumatism

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A patient with systemic lupus erythematosus developed an acute surgical abdomen secondary to spontaneous rupture of the liver and died. Postmortem examination revealed an arteritis of the liver, pancreas, adrenal gland, skeletal muscle, and spleen. It appeared that an arteritis of the liver produced areas of infarction that ruptured and caused the clinical findings.The clinical features of patients with systemic lupus erythematosus (SLE) vary depending on the organs involved. One organ, the liver, is rarely involved with clinically significant disease ( I ) . We report an unusual case of SLE with spontaneous rupture of the liver secondary to arteritis. CASE REPORTA 27-year-old black female with SLE was admitted to the University of Virginia Medical Center for evaluation of Submitted for publication May 7. 1976; accepted September 27. 1976. renal failure. SLE was diagnosed in 1967 because of Raynaud's phenomenon, arthritis, malar facial rash, sun sensitivity, and positive lupus erythematosus cell test and serum fluorescent antinuclear antibody test. She responded to prednisone. which was discontinued in 1970. Later she took aspirin for intermittent arthritis. She remained relatively well until the twenty-fourth week of her fourth pregnancy, when proteinuria was first detected. At that time a creatinine clearance was normal. but serum concentration of C3 was low. One month before admission, following the delivery of a 32-week old baby. she developed intermittent abdominal pain, hypertension, ascites. and a n elevated serum creatinine (3.5 mg/dl).On physical examination the patient was in no acute distress. Vital signs were normal except for a blood pressure of 160/100 rnm Hg. There was mild erythema and hypopigmentation over the bridge of the nose and rnalar area. A grade 2/6 systolic ejection murmur was heard along the left sternal border without radiation. The abdomen was nontender, tense with fluid, and without organomegaly. Pelvic and rectal examinations were unremarkable. Edema of the legs and sacrum were noted, as were small effusions of both knees.Admission laboratory data included a blood urea nitrogen of 58 mg/dl, serum creatinine 2.9 mg/dl, serum albumin 2.5 mg/dl, urinalysis 3+ protein with 9 white cells per high power field, a 24-hour total urine protein of 2.8 g. hematocrit 34% and white blood count 9400/mm3, positive fluorescent antinuclear antibody test, and total hernolytic complement 21 units (normal: 3 4 4 8 units). Cryoglobulins, anti-DNA antibody, and Clq precipitable immune complexes were not detected. Roentgenograms of the abdomen showed diffuse haziness consistent with intraperitoneal fluid. A chest roentgenogram demonstrated elevated diaphragms bilaterally with right basilar atelectasis. A diagnostic paracentesis yielded clear yellow fluid with 48 white blood cells/mm3 (56% polymorphonuclear leukocytes and 44% monocytes), glucose of 103 mg/dl, and protein of 3.0 g/dl. N o organisms were cultured from the fluid and malignant cells were not revealed by cytologic examination.

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Thymoma and the nephrotic syndrome a report of a case

Posner

Prout

Berk

1980

Cancer

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A 48-year-old male presented with the nephrotic syndrome 3 years after resection and irradiation of a thymoma. Renal biopsy revealed membranous glomerulonephritis by electron microscopy. IgA, IgG, and C3 deposition were present in the glomerular basement membrane by immunofluorescence. There was no evidence of other autoimmune diseases or causes of the membranous glomerulonephritis. He has continued to have proteinuria and edema 1 year later.

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Ventriculojugular shunt nephritis with Corynebacterium bovis

Cited by 49 publications

References 10 publications

Shunt Nephritis Associated with <i>Propionibacterium acnes</i> with Demonstration of the Antigen in the Glomeruli

Shunt Nephritis Associated with <i>Propionibacterium acnes</i> with Demonstration of the Antigen in the Glomeruli

Spontaneous rupture of the liver

Thymoma and the nephrotic syndrome a report of a case

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