Ventriculo-arterial coupling in patients with stable ischemic heart disease undergoing percutaneous coronary intervention

Duc, Hung Tran; Thu, Ha Pham Vu; Truong, Vien T.; Ngo, Tam N.M.; Mazur, Wojciech; Chung, Eugene S.; Oanh, Oanh Nguyen; Viet, Tien Tran; Cong, Thuc Luong

doi:10.1007/s10554-021-02437-3

Cited by 3 publications

(5 citation statements)

References 17 publications

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“…After excluding obvious acute, subacute or chronic cardiac complications, like myocarditis or myocardial infarction, hsTn may be found elevated in SLE implicating cardiac involvement [14]. In agreement with recent research, our study verified increased hsTn levels in SLE patients characterized by lack of apparent kidney or cardiac dysfunction and a low CV risk profile [12]. Compared to that study, which utilized PWV and categorized hsTn and PWV as dichotomous variables, our study employed CAVI to assess arterial stiffness and analyzed both hsTn and CAVI as continuous variables.…”

Section: Discussionsupporting

confidence: 91%

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Altered Arterial Stiffness, Ventricular-Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematous

Kadoglou,

Dimopoulou,

Gkougkoudi

et al. 2024

Preprint

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Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease associated with an increased risk of cardiovascular diseases (CVD), leading to elevated mortality rates among patients. We aimed to evaluate the levels of cardio-ankle vascular index (CAVI), global longitudinal strain (GLS), ventricular-arterial coupling (VAC) and high-sensitivity cardiac troponin (hsTn), in SLE patients and to explore their relationship with clinical parameters. Methods: This cross-sectional study enrolled 82 SLE patients without evident cardiac or kidney impairment and 41 age- and sex matched healthy controls. We comparatively evaluated CAVI, GLS, VAC, and hsTn between SLE patients and controls, and we assessed their association among SLE patients with disease activity based on the SELENA-SLEDAI Activity Index. Multivariate regression analysis was performed to identify independent predictors of CAVI and hsTn within the SLE cohort. Results: In comparison to healthy controls, SLE patients presented with significantly higher CAVI, GLS and hsTn levels, while VAC was significantly reduced (p&lt;0.001). Further, SLE patients with active disease (SELENA-SLEDAI≥4) exhibited higher levels of CAVI and troponin than those with inactive disease (p&lt;0.001). SLEDAI was an independent predictor of CAVI, while VAC and SLEDAI were independent determinants of hsTn in SLE cohort. Conclusion: SLE patients displayed abnormal levels of CAVI, VAC, GLS, and troponin compared to healthy individuals. Our findings implicate the potential of those CV novel CVD risk factors to refine screening and therapeutic strategies for this specific population.

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Section: Discussionsupporting

confidence: 91%

“…The interplay between cardiac dysfunction and increased afterload due to arterial stiffening is well-depicted by VAC estimation. Several parameters have been proposed for VAC calculation [12]. Recently, the PWV/GLS ratio has been proposed as a reliable, feasible, easily performed, and reproducible index of VAC with prognostic value [13].…”

Section: Introductionmentioning

confidence: 99%

Altered Arterial Stiffness, Ventricular-Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematous

Kadoglou,

Dimopoulou,

Gkougkoudi

et al. 2024

Preprint

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show abstract

“…After excluding obvious acute, subacute, or chronic cardiac complications, like myocarditis or myocardial infarction, hsTn may be found elevated in SLE implicating most usually cardiac involvement or other extra-cardiac causes which was difficult to identify and rule out in our study [16]. In agreement with recent research, our study verified increased hsTn levels in SLE patients characterized by a lack of apparent kidney or cardiac dysfunction and a low CV risk profile [14]. Compared to that study, which utilized PWV and categorized hsTn and PWV as dichotomous variables, our study employed CAVI to assess arterial stiffness and analyzed both hsTn and CAVI as continuous variables.…”

Section: Discussionsupporting

confidence: 79%

“…The interplay between cardiac dysfunction and increased afterload due to arterial stiffening is well depicted by VAC estimation. Several parameters have been proposed for VAC calculation [14]. Recently, the PWV/GLS ratio has been proposed as a reliable, feasible, easily performed, and reproducible index of VAC with prognostic value [15].…”

Section: Introductionmentioning

confidence: 99%

Altered Arterial Stiffness, Ventricular–Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematosus

Kadoglou,

Dimopoulou,

Gkougkoudi

et al. 2024

Medicina

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Introduction: Systemic Lupus Erythematosus (SLE) is an autoimmune disease associated with an increased risk of cardiovascular diseases (CVDs), leading to elevated mortality rates among patients. We aimed to evaluate the levels of cardio–ankle vascular index (CAVI), global longitudinal strain (GLS), ventricular–arterial coupling (VAC), and high-sensitivity cardiac troponin I (hsTnI) in SLE patients and to explore their relationship with clinical parameters. Methods: This cross-sectional study enrolled 82 SLE patients without evident cardiac or kidney impairment and 41 age- and sex-matched healthy controls. We comparatively evaluated CAVI, GLS, VAC, and hsTnI between SLE patients and controls, and we assessed their association among SLE patients with disease activity based on the SELENA–SLEDAI Activity Index. Multivariate regression analysis was performed to identify independent predictors of CAVI and hsTnI within the SLE cohort. Results: In comparison to healthy controls, SLE patients presented with significantly higher CAVI, GLS, and hsTnI levels, while VAC was significantly reduced (p < 0.001). Furthermore, SLE patients with active disease (SELENA–SLEDAI ≥ 4) exhibited higher levels of CAVI and troponin than those with inactive disease (p < 0.001). SLEDAI was an independent predictor of CAVI, while VAC and SLEDAI were independent determinants of hsTnI in the SLE cohort. Conclusions: SLE patients displayed abnormal levels of CAVI, VAC, GLS, and troponin compared to healthy individuals. Our findings implicate the potential of those CV novel CVD risk factors to refine screening and therapeutic strategies for this specific population.

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“…Regarding the controversial management of stable ischemic heart disease, a recent study demonstrated that percutaneous revascularization led to a significant improvement in the E a /E es ratio (measured by Chen's method, due to improved E es after a 6-month follow-up [54].…”

Section: Coronary Artery Diseasementioning

confidence: 99%

Development and Clinical Application of Left Ventricular–Arterial Coupling Non-Invasive Assessment Methods

Gamarra,

Díez-Villanueva,

Salamanca

et al. 2024

JCDD

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The constant and dynamic interaction between ventricular function and arterial afterload, known as ventricular-arterial coupling, is key to understanding cardiovascular pathophysiology. Ventricular–arterial coupling has traditionally been assessed invasively as the ratio of effective arterial elastance over end-systolic elastance (Ea/Ees), calculated from information derived from pressure–volume loops. Over the past few decades, numerous invasive and non-invasive simplified methods to estimate the elastance ratio have been developed and applied in clinical investigation and practice. The echocardiographic assessment of left ventricular Ea/Ees, as proposed by Chen and colleagues, is the most widely used method, but novel echocardiographic approaches for ventricular–arterial evaluation such as left ventricle outflow acceleration, pulse-wave velocity, and the global longitudinal strain or global work index have arisen since the former was first published. Moreover, multimodal imaging or artificial intelligence also seems to be useful in this matter. This review depicts the progressive development of these methods along with their academic and clinical application. The left ventricular–arterial coupling assessment may help both identify patients at risk and tailor specific pharmacological or interventional treatments.

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Ventriculo-arterial coupling in patients with stable ischemic heart disease undergoing percutaneous coronary intervention

Cited by 3 publications

References 17 publications

Altered Arterial Stiffness, Ventricular-Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematous

Altered Arterial Stiffness, Ventricular-Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematous

Altered Arterial Stiffness, Ventricular–Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematosus

Development and Clinical Application of Left Ventricular–Arterial Coupling Non-Invasive Assessment Methods

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