Ventriculitis caused by <i>Aspergillus fumigatus</i> in a child with central nervous system tuberculosis

Antachopoulos, Charalampos; Stergiopoulou, Theodouli; Simitsopoulou, Maria; Georgiadou, Elpiniki; Kottas, Sotirios; Marinopoulos, Dimitrios; Anastasiou, Athanasia; Roilides, Emmanuel

doi:10.1111/j.1439-0507.2010.01940.x

Cited by 3 publications

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“…5,6,36,50e68 In patients with a diagnosis of meningitis fever and headache were the most common presenting symptoms (78.8%) followed by neck stiffness in 28.2% (24/85). 3e6,9e76 3,6,10,12,13,15,22,23,25e27,29,32,33,39,44,45,47,52,54,56,58,63,76,78,79 PR as opposed to immunocompromised individuals (39%). 5,9,28,29,34,36,40,42,46,48,55,59,74 This difference might be explained by a more aggressive and acute course of the disease observed in immunosuppressed hosts.…”

Section: Discussionmentioning

confidence: 99%

Aspergillus meningitis: A rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases

Antinori

Corbellino

Meroni

et al. 2013

Journal of Infection

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Section: Discussionmentioning

confidence: 99%

Aspergillus meningitis: A rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases

Antinori

Corbellino

Meroni

et al. 2013

Journal of Infection

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Successful treatment ofAspergillusventriculitis through voriconazole adaptive pharmacotherapy, immunomodulation, and therapeutic monitoring of cerebrospinal fluid (1→3)-β-D-glucan

et al. 2016

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Aspergillus ventriculitis is an uncommon but often fatal form of invasive aspergillosis of the central nervous system (CNS). As little is known about the diagnosis, treatment, and outcome of this potentially lethal infection, we report the strategies used to successfully treat Aspergillus ventriculitis complicating a pineal and pituitary germinoma with emphasis on the critical role of adaptive pharmacotherapy of voriconazole and serial monitoring of (1→3)-β-D-glucan in cerebrospinal fluid. We describe several rationally based therapeutic modalities, including adaptive pharmacotherapy, combination therapy, sargramostim-based immunomodulation, and biomarker-based therapeutic monitoring of the CNS compartment. Through these strategies, our patient remains in remission from both his germinoma and Aspergillus ventriculitis making him one of the few survivors of Aspergillus ventriculitis.

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A Case Report

Maldonado-Díaz¹,

Delgado-Hernández

Salinas-Lara

et al. 2020

Infect Dis Clin Pract

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Fungal meningitis is often a fatal condition, particularly in immunosuppressed patients. Herein, we describe the case of a previously healthy young woman with a history of epidural anesthesia for a cesarean delivery in another hospital 3 months prior. The patient complained of chronic migraine-like headache before admission to our center. After 5 weeks, a cerebrospinal fluid culture in Sabouraud agar grew a mold, later identified as Aspergillus fumigatus. The patient died after 114 days of hospitalization despite being administered with voriconazole for 45 days. At autopsy, a pigmented mold consistent with phaeohyphomycosis was found, suggesting an unusual case of a mixed mold infection.

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Ventriculitis caused by Aspergillus fumigatus in a child with central nervous system tuberculosis

Cited by 3 publications

References 0 publications

Aspergillus meningitis: A rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases

Aspergillus meningitis: A rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases

Successful treatment ofAspergillusventriculitis through voriconazole adaptive pharmacotherapy, immunomodulation, and therapeutic monitoring of cerebrospinal fluid (1→3)-β-D-glucan

A Case Report

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