Ventricular volume, white matter alterations and outcome of major depression and their relationship to endocrine parameters – A pilot study

Murck, Harald; Luerweg, Benjamin; Hahn, Johannes; Braunisch, Matthias C.; Ježová, Daniela; Zavorotnyy, Maxim; Konrad, Carsten; Jansen, Andreas; Kircher, Tilo

doi:10.1080/15622975.2020.1757754

Cited by 10 publications

(11 citation statements)

References 102 publications

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“…Interestingly, and a link between increased ventricular volume and metabolic dysfunction, in particular hyperlipidemia, in subjects with normal pressure hydrocephalus 58 has also been observed. Similarly, in our pilot study we previously described a strong correlation between BMI and both choroid plexus-and ventricular volume 19 .…”

Section: Discussionsupporting

confidence: 80%

“…Disturbance of white matter integrity has indeed frequently been described in patients with depressive disorders, mainly by using diffusion tensor imaging (DTI) methods [38][39][40][41][42][43] . In support of the hypothesis of the choroid plexus involvement in this pathway: the activity of the choroid plexus is affected by neuroendocrine influences, which have been linked to MDD, in particular vasopressin and aldosterone 19,37 , as well as metabolic markers related to an increased BMI 19,44 . These findings are also in line with the role of inflammation as both aldosterone [45][46][47] and high BMI [48][49][50][51] show a close association to increased inflammation.…”

Section: Discussionmentioning

confidence: 67%

“…A working hypothesis could be that changes in choroid plexus function, i.e. an increased release of CSF volume 19,37 , or an increased release of specific bioactive molecules, including inflammation mediators 24,31 , may lead to a change in white matter volume and/or integrity. The increased ventricular volume or, alternatively, such bioactive molecules may affect white matter function either by mechanical compression or an effect on white matter integrity via alternations of oligodendrocyte function.…”

Section: Discussionmentioning

confidence: 99%

“…Limitations of the study are the post hoc nature of the current analyses, however, they were motivated by the attempt to replicate data from an earlier study 19 and the primary variables of interest are identical. Therefore, with all caution, the current analysis overall confirms the previous pilot study.…”

Section: Discussionmentioning

confidence: 99%

“…In the context of depression, VV is increased in patients with depression in comparison to healthy controls [15][16][17] and may be related to treatment outcome 18 . We recently demonstrated an association between an increased choroid plexus and ventricular volume and worse 4 treatment outcome in hospitalized patients with depression and identified moderators of this relationship 19 , i.e. body mass index (BMI) and the salivary aldosterone/cortisol ratio.…”

Section: Introductionmentioning

confidence: 99%

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Brain Ventricle and Choroid Plexus Morphology as Predictor of Treatment Response: Findings from the EMBARC Study

Murck

Fava

Cusin³

et al. 2023

Preprint

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Recent observations suggest a role of the choroid plexus (CP) and cerebral ventricle volume (CV), to identify treatment resistance of major depressive disorder (MDD). We tested the hypothesis that these markers are associated with clinical improvement in subjects from the EMBARC study, as implied by a recent pilot study. The EMBARC study characterized biological markers in a randomized placebo-controlled trial of sertraline vs. placebo in patients with MDD. Association of baseline volumes of CV, CP and of the corpus callosum (CC) with treatment response after 4 weeks treatment were evaluated. 171 subjects (61 male, 110 female) completed the 4 week assessments; gender, site and age were taken into account for this analyses. As previously reported, no treatment effect of sertraline was observed, but prognostic markers for clinical improvement were identified. Responders (n = 54) had significantly smaller volumes of the CP and lateral ventricles, whereas the volume of mid-anterior and mid-posterior CC was significantly larger compared to non-responders (n = 117). A positive correlation between CV volume and CP volume was observed, whereas a negative correlation between CV volume and both central-anterior and central-posterior parts of the CC emerged. In an exploratory way correlations between enlarged VV and CP volume on the one hand and signs of metabolic syndrome, in particular triglyceride plasma concentrations, were observed. A primary abnormality of CP function in MDD may be associated with increased ventricles, compression of white matter volume, which may affect treatment response speed or outcome. Metabolic markers may mediate this relationship.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Brain Ventricle and Choroid Plexus Morphology as Predictor of Treatment Response: Findings from the EMBARC Study

Murck

Fava

Cusin³

et al. 2023

Preprint

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A preliminary choroid plexus volumetric study in individuals with psychosis

Şenay

Seethaler

Makris

et al. 2023

Human Brain Mapping

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The choroid plexus (ChP) is part of the blood‐cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging‐based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual segmentation to measure ChP volumes. We applied ANCOVAs to compare normalized ChP volumes between groups and partial correlations to investigate the relationship between ChP, LV volumes, and clinical characteristics. Our segmentation demonstrated good reliability (.87). We further showed a significant ChP volume increase in early psychosis (left: p < .00010, right: p < .00010) and a significant positive correlation between higher ChP and higher LV volumes in chronic psychosis (left: r = .54, p = .0030, right: r = .68; p < .0010). Our study suggests that ChP enlargement may be a marker of acute response around disease onset. It might also play a modulatory role in the chronic enlargement of lateral ventricles, often reported in psychosis. Future longitudinal studies should investigate the dynamics of ChP enlargement as a promising marker for novel therapeutic strategies.

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Volume enlargement of the choroid plexus and brain ventricles in drug-naïve, first-episode major depressive disorder

Hayasaki,

Chibaatar,

Watanabe

et al. 2024

Journal of Affective Disorders

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Ventricular volume, white matter alterations and outcome of major depression and their relationship to endocrine parameters – A pilot study

Cited by 10 publications

References 102 publications

Brain Ventricle and Choroid Plexus Morphology as Predictor of Treatment Response: Findings from the EMBARC Study

Brain Ventricle and Choroid Plexus Morphology as Predictor of Treatment Response: Findings from the EMBARC Study

A preliminary choroid plexus volumetric study in individuals with psychosis

Volume enlargement of the choroid plexus and brain ventricles in drug-naïve, first-episode major depressive disorder

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