Ventricular tachycardia revealing drug abuse induced myocarditis: two case reports

Ouali, Sana; Guermazi, Omar; Halima, M. Ben; Boudiche, Sélim; Khedher, Nadim; Adeljalil, Farhati; Meghaeith, Fathia; Larbi, N.; Mourali, Mechaal

doi:10.1002/ccr3.1542

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Ventricular tachycardia has been reported with cocaine use in patients with myocarditis supported by MRI-proven subepicardial scar. 43 Reports of frequent premature ventricular contractions (PVCs), nonsustained ventricular tachycardia, idioventricular rhythm, sustained ventricular tachycardia, ventricular fibrillation, torsade de pointes, and sudden cardiac death (SCD), have been reported in patients aged 20 to 44 without underlying ischemia. 44 Animal studies indicate post-MI episodes of ventricular fibrillation after cocaine exposure are reduced by verapamil.…”

Section: Cocaine and Atrial Arrhythmiasmentioning

confidence: 99%

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Dominic

Ahmad

Awwab

et al. 2022

Circ: Arrhythmia and Electrophysiology

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Nonmedical use of prescription and nonprescription drugs is a worldwide epidemic, rapidly growing in magnitude with deaths because of overdose and chronic use. A vast majority of these drugs are stimulants that have various effects on the cardiovascular system including the cardiac rhythm. Drugs, like cocaine and methamphetamine, have measured effects on the conduction system and through several direct and indirect pathways, utilizing multiple second messenger systems, change the structural and electrical substrate of the heart, thereby promoting cardiac dysrhythmias. Substituted amphetamines and cocaine affect the expression and activation kinetics of multiple ion channels and calcium signaling proteins resulting in EKG changes, and atrial and ventricular brady and tachyarrhythmias. Preexisting conditions cause substrate changes in the heart, which decrease the threshold for such drug-induced cardiac arrhythmias. The treatment of cardiac arrhythmias in patients who take drugs of abuse may be specialized and will require an understanding of the unique underlying mechanisms and necessitates a multidisciplinary approach. The use of primary or secondary prevention defibrillators in drug abusers with chronic systolic heart failure is both sensitive and controversial. This review provides a broad overview of cardiac arrhythmias associated with stimulant substance abuse and their management.

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Section: Cocaine and Atrial Arrhythmiasmentioning

confidence: 99%

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Dominic

Ahmad

Awwab

et al. 2022

Circ: Arrhythmia and Electrophysiology

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“…Кроме того, электрическую нестабильность миокарда может вызвать снижение эффективности коронарного кровотока под влиянием кокаина [9]. Описаны случаи, когда интоксикация кокаином вызвала остановку сердца (асистолия) с последующей фибрилляцией желудочков, желудочковую тахикардию на фоне повреждения миокарда [19,20].…”

Section: нарушения ритма и проводимостиunclassified

Cocaine as a Risk Factor for Heart and Vascular Disease. Part 1

Зыбалова¹,

Dostanko²,

Ягур³

et al. 2022

Кардиология В Беларуси

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В обзоре приведены основные свойства, формы, метаболизм, фармакокинетика кокаина, возможные результаты его взаимодействия с другими веществами и лекарственными средствами, различные аспекты влияния кокаина на сердечно-сосудистую систему. Подробно рассмотрены механизмы действия кокаина, лежащие в основе развития основных широко распространенных патологических процессов в сердце и сосудах. Проанализированы данные большого числа опубликованных исследований, посвященных влиянию кокаина на развитие различных нарушений проводимости и ритма сердца, артериальной гипертензии, эндотелиальной дисфункции, расслоение крупных артерий и аорты. Также обсуждены особенности действия кокаина в разных группах пациентов и в зависимости от длительности его употребления. Приведены рекомендации по диагностике и выбору терапии при ряде патологических состояний, связанных с употреблением кокаина. Особое внимание уделено спорным вопросам лечения и влияния кокаина на сердце и сосуды, диагностическим возможностям различных методов исследования. The review presents the main properties, forms, metabolism, pharmacokinetics of cocaine, possible results of its interaction with other substances and medicines, various aspects of cocaine effect on the cardiovascular system. The mechanisms of cocaine action underlying the development of the main widespread pathological processes in the heart and blood vessels, are considered in detail. The data of a large number of published studies on the cocaine influence on the development of various disorders of conduction and heart rhythm, arterial hypertension, endothelial dysfunction, and dissection of large arteries and aorta are analyzed. The particulars of action with the duration of cocaine use as well as in different groups of patients are discussed. Recommendations are given for the diagnostics and choice of therapy for a number of pathological conditions associated with cocaine use. Particular attention is paid to controversial issues of treatment and effect of cocaine on the heart and blood vessels, the diagnostic capabilities of various diagnostic methods.

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Management of patients with an electrical storm or clustered ventricular arrhythmias: a clinical consensus statement of the European Heart Rhythm Association of the ESC—endorsed by the Asia-Pacific Heart Rhythm Society, Heart Rhythm Society, and Latin-American Heart Rhythm Society

Lenarczyk,

Zeppenfeld,

Tfelt-Hansen

et al. 2024

Europace

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Electrical storm (ES) is a state of electrical instability, manifesting as recurrent ventricular arrhythmias (VAs) over a short period of time (three or more episodes of sustained VA within 24 h, separated by at least 5 min, requiring termination by an intervention). The clinical presentation can vary, but ES is usually a cardiac emergency. Electrical storm mainly affects patients with structural or primary electrical heart disease, often with an implantable cardioverter-defibrillator (ICD). Management of ES requires a multi-faceted approach and the involvement of multi-disciplinary teams, but despite advanced treatment and often invasive procedures, it is associated with high morbidity and mortality. With an ageing population, longer survival of heart failure patients, and an increasing number of patients with ICD, the incidence of ES is expected to increase. This European Heart Rhythm Association clinical consensus statement focuses on pathophysiology, clinical presentation, diagnostic evaluation, and acute and long-term management of patients presenting with ES or clustered VA.

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Ventricular tachycardia revealing drug abuse induced myocarditis: two case reports

Cited by 3 publications

References 11 publications

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Cocaine as a Risk Factor for Heart and Vascular Disease. Part 1

Management of patients with an electrical storm or clustered ventricular arrhythmias: a clinical consensus statement of the European Heart Rhythm Association of the ESC—endorsed by the Asia-Pacific Heart Rhythm Society, Heart Rhythm Society, and Latin-American Heart Rhythm Society

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