Ventricular Tachycardia in a Patient on Dehydroemetine and Chloroquine for Amoebic Liver Abscess

Seshadri, M. S.; John, Lily; Varkey, Kuruvilla; Koshy, Thomas

doi:10.5694/j.1326-5377.1979.tb127000.x

Cited by 10 publications

(12 citation statements)

References 8 publications

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“…Another essential aspect to be discussed is about chloroquine cardiovascular side effects since this is one of the promising drugs that have been tested in patients with COVID‐19. It is well‐reported that long‐term chloroquine use may increase depolarization length duration and Purkinje fiber refractory period, 31‐34 ultimately leading to atrioventricular nodal and/or His system malfunction 31…”

Section: Introductionmentioning

confidence: 99%

“…As an antimalarial drug, both chloroquine and hydroxychloroquine (HCQ) are accumulated in lysosomes, directly inhibiting phospholipase activity, inducing cytoplasmic inclusion body formation, increasing lysosomal pH, and causing protein inactivity 31,35 . Due to these properties, drug‐induced atrial and VAs have been associated with their use 31‐35 . The most usual electrocardiographic alteration is fascicular block, which can lead to advanced types of atrioventricular block, generally associated with syncope 36…”

Section: Introductionmentioning

confidence: 99%

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Cardiac and arrhythmic complications in patients with COVID‐19

Kochi

Tagliari

Forleo

et al. 2020

Cardiovasc electrophysiol

591

517

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In December 2019, the world started to face a new pandemic situation, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Although coronavirus disease (COVID-19) clinical manifestations are mainly respiratory, major cardiac complications are being reported. Cardiac manifestations etiology seems to be multifactorial, comprising direct viral myocardial damage, hypoxia, hypotension, enhanced inflammatory status, ACE2-receptors downregulation, drug toxicity, endogenous catecholamine adrenergic status, among others. Studies evaluating patients with COVID-19 presenting cardiac injury markers show that it is associated with poorer outcomes, and arrhythmic events are not uncommon. Besides, drugs currently used to treat the COVID-19 are known to prolong the QT interval and can have a proarrhythmic propensity. This review focus on COVID-19 cardiac and arrhythmic manifestations and, in parallel, makes an appraisal of other virus epidemics as SARS-CoV, Middle East respiratory syndrome coronavirus, and H1N1 influenza. K E Y W O R D S arrhythmia, COVID-19, myocardial damage, myocarditis, SARS-CoV-2 | KOCHI ET AL.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiac and arrhythmic complications in patients with COVID‐19

Kochi

Tagliari

Forleo

et al. 2020

Cardiovasc electrophysiol

591

517

View full text Add to dashboard Cite

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“…Amoebiasis has been known to present with cardiac manifestations, most commonly arrhythmias due to cardiotoxicity of the now outmoded drugs emetine and dihydroemetine. Seshadri et al 9 have reported one case of multiple episodes of ventricular tachycardia in a patient of amoebic liver abscess receiving emetine and chloroquine. Rarely, an amoebic liver abscess may spread contiguously to involve the pericardium (amoebic pericarditis) 10.…”

Section: Discussionmentioning

confidence: 99%

Syncope in a patient being treated for hepatic and intestinal amoebiasis

et al. 2012

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SummaryA 63-year-old man presented to our hospital with amoebic liver abscess and was treated successfully for the same. During the course of his treatment, he developed syncopal attacks and was found to have Torsades de Pointes on electrocardiogram. The patient was treated with intravenous magnesium and direct current cardioversion. Hypokalaemia, chloroquine and sepsis were suspected to have precipitated the arrhythmia. The patient remained arrhythmia-free following the correction of these factors. BACKGROUND

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“…Because of its properties, drug-induced arrhythmias and also atrial and ventricular antiarrhythmic effects have been described [16][17][18][19][20][21][22][23][24][25] .…”

Section: Discussionmentioning

confidence: 99%

“…Major arrhythmias caused by chronic use of chloroquine have been related to a significant reduction in the cardiac ascent rate, increases in the potential length duration, and Purkinje fibers refractory period 17,[23][24][25] .…”

Section: Discussionmentioning

confidence: 99%

Cardiac Damage from Chronic Use of Chloroquine: A Case Report and Review of the Literature

Teixeira

Filho

Benvenuti

et al. 2002

Arq. Bras. Cardiol.

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Chloroquine has been widely used in rheumatological treatment, but potential severe side effects require careful follow-up. Cardiac damage is not a common consequence, but its clinical relevance has not yet been described. We report the case of a 58-year-old woman with rheumatoid arthritis, in whom chronic chloroquine use resulted in major irreversible cardiac damage. She presented with syncopal episodes due to complete atrioventricular block confirmed by electrophysiological study whose changes were concluded to be irreversible and a permanent pacemaker was indicated. Endomyocardial biopsy was also performed to search for histopathological and ultrastructural cardiac damage. We also reviewed the 22 cases of chloroquine-induced cardiopathy described to date as well as its pathophysiology.

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Ventricular Tachycardia in a Patient on Dehydroemetine and Chloroquine for Amoebic Liver Abscess

Cited by 10 publications

References 8 publications

Cardiac and arrhythmic complications in patients with COVID‐19

Cardiac and arrhythmic complications in patients with COVID‐19

Syncope in a patient being treated for hepatic and intestinal amoebiasis

Cardiac Damage from Chronic Use of Chloroquine: A Case Report and Review of the Literature

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