Ventricular Tachycardia Associated with Thyrotoxicosis

Fairhurst, B. J.; Sash, Leonard

doi:10.1136/bmj.2.5153.677

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…(6) Hyperthyroidism does not only trigger off atrial fibrillation but has been found to induce all kinds of dysrhythmias and conduction disturbances in patients of over 40 years of age depending on concomitant pathophysiological conditions (Cookson, 1959;Fairhurst and Sash, 1959;Lyngborg and Jacobsen, 1972). Therefore, there is no need to leave the hyperthyroid patient, with his disturbing symptoms of palpitations or atrial fibrillation with fast ventricular rate and decreased cardiac output and effort tolerance (Benchimol, Lowe and Akre, 1965;Bouma and May, 1967), until stable euthyroid state is obtained and hoping atrial fibrillation will spontaneously convert to sinus rhythm.…”

Section: Discussionmentioning

confidence: 99%

“…block (Cookson, 1959;Blizzard and Rupp, 1960;Hoffman and Lowrey, 1960;Rosenblum and Delman, 1963;Lanfranchi and Fauchier, 1973), third degree of a.v. block (Davis and Smith, 1933;Steuer, 1936;Muggia, Stjernholme and Houle, 1970;Stern, Jacobs and Duncan, 1970;Kernoff, Rossouw and Kennelly, 1972), reversible bundle branch block (Digilio, 1938), ventricular ectopic beats (Rohrbach, 1968), ventricular tachycardia (Ernstene, 1938;Fairhurst and Sash, 1959;Lyngborg and Jacobsen, 1972) and ventricular fibrillation (Boone, 1945;Lyngborg and Jacobsen, 1972). These dysrhythmias, although some are rare, have been described in patients of over 40 years of age who also had coronary artery disease, hypertension or acute infections.…”

Section: Introductionmentioning

confidence: 99%

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Atrial fibrillation and hyperthyroidism: a new look at their relationship and therapy with lidoflazine

Bruyneel¹,

Verhaegen²,

Vil

1975

Postgraduate Medical Journal

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Summary Various kinds of dysrhythmias are found in association with hyperthyroidism but especially atrial fibrillation. The causal relationship of chronic atrial fibrillation and the endocrine disorder is controversial, as is its therapeutic management. Six patients with this particular combination of disorders were treated with lidoflazine: a new anti-anginal drug with anti-arrhythmic activity. All six patients returned to sinus rhythm on lidoflazine treatment although still hyperthyroid and remained in sinus rhythm during the follow up period ranging from 5 to 14 months. This occurred independently of antithyroid treatment. Some evidence is put forward that dysrhythmias and most commonly chronic atrial fibrillation are triggered off by hyperthyroidism or other disorders but that they are maintained by permanent cardiac damage due to arteriosclerosis, hypertension, coronary heart disease or rheumatic valve disease. Successful chemical cardioversions and maintenance of sinus rhythm can be obtained independent of the thyroid function. Our results confirm the anti-arrhythmic activity of lidoflazine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Atrial fibrillation and hyperthyroidism: a new look at their relationship and therapy with lidoflazine

Bruyneel¹,

Verhaegen²,

Vil

1975

Postgraduate Medical Journal

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A-V conduction in hyper- and hypothyroid dogs

Goel¹,

Hanson²,

Han³

1972

American Heart Journal

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Studies on Digitalis

Frye

Braunwald

1961

Circulation

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The effects of triiodothyronine (T 3 ) administration on digitalis requirements was studied in a group of patients with atrial fibrillation. The ventricular rate was utilized to provide a quantitative expression of digitalis effect. In one patient the amount of acetylstrophanthidin, administered as a constant infusion, required to slow the ventricular rate to 70 beats per minute rose from an average of 0.58 mg. while he was myxedematous, to 1.50 mg. when he was euthyroid. When mild thyrotoxicosis was induced in three euthyroid patients the daily dose of digoxin had to be increased approximately four-fold in order to maintain the ventricular rate at a control level. In three patients it was observed that reserpine or syrosingopine administered intramuscularly abolished the increased requirements for digoxin induced by T 3 . In two patients syrosingopine was found to prevent partially the tachycardia resulting from large doses of intravenous T 3 . The possible mechanisms responsible for these effects and their therapeutic implications are discussed.

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Ventricular Tachycardia Associated with Thyrotoxicosis

Cited by 4 publications

References 5 publications

Atrial fibrillation and hyperthyroidism: a new look at their relationship and therapy with lidoflazine

Atrial fibrillation and hyperthyroidism: a new look at their relationship and therapy with lidoflazine

A-V conduction in hyper- and hypothyroid dogs

Studies on Digitalis

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