Ventricular septal defect: Results after repair in infancy

Sigmann, Joan M.; Perry, Burton L.; Behrendt, Douglas M.; Stern, Aaron; Kirsh, Marvin M.; Sloan, Herbert

doi:10.1016/s0002-9149(77)80013-1

Cited by 47 publications

(19 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Correlations between the various histologic features were also evaluated for the group as a whole and separately for those younger and older than two years since surgical repair before this age has been recommended for patients with VSD [4,6,28]. For the patients whose VSD was closed, the change in Ppa after closure was related to the hemodynamic data obtained at the preoperative catheterization and the biopsy data.…”

Section: Statandticsmentioning

confidence: 99%

“…Recent studies have suggested that ventricular septal defects be closed by the age of two years since, in most patients operated on earlier than this, pulmonary artery pressure and pulmonary vascular resistance return to normal [4,6,28]. These studies are of small series of patients, with only three [28] to 13 [4] cases under the age of two years.…”

Section: Relationship Between Preoperative Features and The Fau In Ppmentioning

confidence: 99%

“…These studies are of small series of patients, with only three [28] to 13 [4] cases under the age of two years. In a large series with 57 children operated on under the age of two years but with a variety of cardiac lesions which produce pulmonary hypertension, several children less than two years, but none under nine months at the time of operation, had elevated pulmonary vascular resistance one year postoperatively.…”

Section: Relationship Between Preoperative Features and The Fau In Ppmentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary arterial changes in patients with ventricular septal defects and severe pulmonary hypertension

et al. 1986

View full text Add to dashboard Cite

In 25 patients, aged eight months to 31 years, with ventricular septal defect (VSD; isolated in 15, the others with atrial septal defect, PDA, coarctation or patent ductus arteriosus + coarctation), each with severe pulmonary artery hypertension (pulmonary artery systolic pressure [Ppa] at least 75% of systemic and an elevated pulmonary vascular resistance), we related morphologic and morphometric data from open-lung biopsy to hemodynamic measurements obtained at cardiac catheterization during the same hospital admission. Of the hemodynamic features measured, only the ratios of pulmonary-to-systemic flow and pulmonary-to-systemic resistance correlated significantly with structure. Neither pulmonary artery pressure (Ppa) nor pulmonary vascular resistance correlated significantly with any structural feature studied. The increased external diameter of respiratory bronchiolar arteries in those with the more advanced Heath-Edwards grades reflects dilatation and suggests that it is in the small arteries of the distal arterial bed that the changes of pulmonary hypertension are most significant. Neither age nor body weight correlated significantly with the degree of structural or hemodynamic abnormality. In the ten patients who underwent VSD closure, Ppa was measured postoperatively. The Heath-Edwards grade (no more than one grade-III lesion) and arterial density (at least one-half that normal for age) were the best correlates of the difference between preoperative Ppa and Ppa immediately after corrective surgery. The presurgical catheterization data, including pulmonary resistance and the resistance ratio, did not correlate significantly with change in Ppa following VSD closure.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: Statandticsmentioning

confidence: 99%

Section: Relationship Between Preoperative Features and The Fau In Ppmentioning

confidence: 99%

Section: Relationship Between Preoperative Features and The Fau In Ppmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary arterial changes in patients with ventricular septal defects and severe pulmonary hypertension

et al. 1986

View full text Add to dashboard Cite

show abstract

“…Reports have been published on the long-term follow-up of surgical closure of the defect. [1][2][3][4] Much attention has been paid to specific aspects, especially conduction distur-bances5-" I and pulmonary vascular diseases'2-16 after surgery. Very little has been written about late death, and to our knowledge no paper in the English journals deals with ventricular arrhythmia and its relation to late death.…”

mentioning

confidence: 99%

Conduction defects, ventricular arrhythmias, and late death after surgical closure of ventricular septal defect.

Blake¹,

Chung²,

Wesley³

et al. 1982

Heart

View full text Add to dashboard Cite

One hundred and eighty-seven patients who had surgical closure of a ventricular septal defect between 1958 and 1975 were followed for up to 21 years. there were 17 late sudden deaths of which eight occurred in completely fit patients while nine were already under medical care. In an attempt to elucidate possible risk factors and reoperative and serial postoperative electrocardiograms of all patients were studied. Fifty-one unselected healthy follow-up patients agreed to 24 hour ambulatory monitoring. Progressive exercise testing (Bruce protocol) was carried out on 31 of them and an additional seven patients. There was a significant correlation between recorded ventricular arrhythmias and conduction defects, particularly progressive conduction defects. Transient complete heart block carried a bad prognosis and grade 3-4b ventricular arrhythmias were a major risk factor and recorded in 10 of the 17 patients who died. Long-term postoperative electrocardiographic follow-up is recommended and 24 hour ambulatory monitoring and exercise testing complement the findings of the resting electrocardiogram. The long-term treatment of survivors found to have ventricular arrhythmias must be considered.

show abstract

“…Conduction disturbances after surgical correction of ventricular septal defects have been well documented (Titus et al, 1963;Kulbertus et al, 1969;Downing et al, 1972;Wolff et al, 1970;Godman et al, 1974;Okoroma et al, 1975;Subramanian, 1976;Sigmann et al, 1977). Surgical technique has been implicated.…”

mentioning

confidence: 99%

Conduction disturbances after surgical correction of ventricular septal defect by the atrial approach.

Hobbins¹,

Izukawa²,

Radford³

et al. 1979

Heart

View full text Add to dashboard Cite

Conduction disturbances have been documented after correction of ventricular septal defects by the ventricular route. Recently, repair of the ventricular septal defect has been through the right atrium to overcome damage to the conduction system and a right ventriculotomy. Thirty-nine children with ventricular septal defects under the age of 5 years were operated upon by the atrial route (group 1). The incidence of conduction disturbances in this group was compared with that occurring in 19 children of comparable age with a ventricular septal defect repaired via a right ventriculotomy (group 2). Complete right bundle-branch block developed in 13 of 39 children (33.3%) in group 1, compared with 15 of 19 children (78.9%) in group 2. This was a statistically significant reduction in complete right bundle-branch block in group 1. The incidence of left axis deviation occurring with complete right bundle-branch block was similarly statistically reduced. Transient complete heart block and arrhythmias were not statistically different in the two groups. The atrial approach to the repair of the ventricular septal defect significantly reduced the incidence of complete right bundle-branch block alone and occurring with left axis deviation.

show abstract

Ventricular septal defect: Results after repair in infancy

Cited by 47 publications

References 18 publications

Pulmonary arterial changes in patients with ventricular septal defects and severe pulmonary hypertension

Pulmonary arterial changes in patients with ventricular septal defects and severe pulmonary hypertension

Conduction defects, ventricular arrhythmias, and late death after surgical closure of ventricular septal defect.

Conduction disturbances after surgical correction of ventricular septal defect by the atrial approach.

Contact Info

Product

Resources

About