Ventricular resynchronization therapy by direct His-bundle pacing using an internal cardioverter defibrillator

Barba-Pichardo, Rafael; Sánchez, Ana Manovel; Fernández-Gómez, Juan Manuel; Moriña‐Vázquez, Pablo; Venegas‐Gamero, José; Herrera-Carranza, Manuel

doi:10.1093/europace/eus228

Cited by 181 publications

(122 citation statements)

References 11 publications

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“…Moreover, the present study did not observe serious adverse events related to implantation procedures, AVN ablation, or late lead dislodgement. Thus, our findings demonstrated that implantation procedures in conjunction with AVN ablation and permanent HBP are safe and stable 12, 13, 14, 15, 16, 17, 18…”

Section: Discussionsupporting

confidence: 59%

“…In 2000, Deshmukh et al first successfully implemented permanent direct HBP in a small number of patients with AF and dilated cardiomyopathy and found improvements in LV dimensions and cardiac function 12. Since then, there have been multiple reports on HBP in patients who need pacemaker therapy including those with AVN ablation or heart failure or patients for conventional pacemaker therapy 13, 14, 15, 16, 17, 18…”

Section: Introductionmentioning

confidence: 99%

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Benefits of Permanent His Bundle Pacing Combined With Atrioventricular Node Ablation in Atrial Fibrillation Patients With Heart Failure With Both Preserved and Reduced Left Ventricular Ejection Fraction

Huang

et al. 2017

JAHA

185

122

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BackgroundClinical benefits from His bundle pacing (HBP) in heart failure patients with preserved and reduced left ventricular ejection fraction are still inconclusive. This study evaluated clinical outcomes of permanent HBP in atrial fibrillation patients with narrow QRS who underwent atrioventricular node ablation for heart failure symptoms despite rate control by medication.Methods and ResultsThe study enrolled 52 consecutive heart failure patients who underwent attempted atrioventricular node ablation and HBP for symptomatic atrial fibrillation. Echocardiographic left ventricular ejection fraction and left ventricular end‐diastolic dimension, New York Heart Association classification and use of diuretics for heart failure were assessed during follow‐up visits after permanent HBP. Of 52 patients, 42 patients (80.8%) received permanent HBP and atrioventricular node ablation with a median 20‐month follow‐up. There was no significant change between native and paced QRS duration (107.1±25.8 versus 105.3±23.9 milliseconds, P=0.07). Left ventricular end‐diastolic dimension decreased from the baseline (P<0.001), and left ventricular ejection fraction increased from baseline (P<0.001) in patients with a greater improvement in heart failure with reduced ejection fraction patients (N=20) than in heart failure with preserved ejection fraction patients (N=22). New York Heart Association classification improved from a baseline 2.9±0.6 to 1.4±0.4 after HBP in heart failure with reduced ejection fraction patients and from a baseline 2.7±0.6 to 1.4±0.5 after HBP in heart failure with preserved ejection fraction patients. After 1 year of HBP, the numbers of patients who used diuretics for heart failure decreased significantly (P<0.001) when compared to the baseline diuretics use.ConclusionsPermanent HBP post–atrioventricular node ablation significantly improved echocardiographic measurements and New York Heart Association classification and reduced diuretics use for heart failure management in atrial fibrillation patients with narrow QRS who suffered from heart failure with preserved or reduced ejection fraction.

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Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Benefits of Permanent His Bundle Pacing Combined With Atrioventricular Node Ablation in Atrial Fibrillation Patients With Heart Failure With Both Preserved and Reduced Left Ventricular Ejection Fraction

Huang

et al. 2017

JAHA

185

122

View full text Add to dashboard Cite

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“…Barba-Pichardo et al described their experience with HBP in failed CRT cases [16] . They attempted HBP in 16 patients with cardiomyopathy and failed CRT (Ischemic cardiomyopathy in 7, Idiopathic in 9).…”

Section: Available Data On Hbp For Crtmentioning

confidence: 99%

His Bundle Pacing Or Biventricular Pacing For Cardiac Resynchronization Therapy In Heart Failure: Discovering New Methods For An Old Problem

Sharma

Vijayaraman

2016

Journal of Atrial Fibrillation

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“…1.5, optical stimulation was more efficient when cell-specific optogenetic targeting was used to express opsins in the PS compared to ventricular cells. This finding is particularly noteworthy because direct pacing of the His bundle has therapeutic advantages compared to conventional pacing for cardiac resynchronization [15], but the practical usefulness of this maneuver is limited by high energy requirements and low selectivity (i.e., electrical stimuli capture the ventricular septum as well as the His bundle). Results from optogenetics simulations indicate that both of these shortcomings could be overcome by using a light-based approach for the same type of stimulation.…”

Section: Exploration Of An Emerging Paradigm For Anti-arrhythmia Treamentioning

confidence: 99%

Cardiac Arrhythmias: Mechanistic Knowledge and Innovation from Computer Models

Trayanova

Boyle

2015

MS&A

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Computational simulation is increasingly recognized as an integral aspect of modern cardiovascular research. Realistic and biophysically detailed models of the cardio-circulatory system can help interpret complex experimental observations, dissect underlying mechanisms, and explain emerging organ-scale phenomena resulting from subtle changes at the tissue, cellular, and/or sub-cellular scales. This chapter provides an overview of recent advances in the simulation of cardiac electrical behavior, focusing specifically on detailed models of the initiation, perpetuation, and termination of ventricular arrhythmias, including fibrillation. The development and validation of such models has opened several noteworthy avenues of research, including close scrutiny of arrhythmia dynamics in healthy and diseased hearts, dissection of arrhythmogenic and cardioprotective properties of specialized cardiac tissue regions such as the Purkinje system, and exploration of emerging paradigms for anti-arrhythmia treatment, such as optogenetics. Excitingly, the clinical community is currently taking the first steps towards using patient-specific ventricular models to stratify arrhythmia risk, personalize treatment planning, and optimize device placement for difficult or unusual procedures.

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Ventricular resynchronization therapy by direct His-bundle pacing using an internal cardioverter defibrillator

Cited by 181 publications

References 11 publications

Benefits of Permanent His Bundle Pacing Combined With Atrioventricular Node Ablation in Atrial Fibrillation Patients With Heart Failure With Both Preserved and Reduced Left Ventricular Ejection Fraction

Benefits of Permanent His Bundle Pacing Combined With Atrioventricular Node Ablation in Atrial Fibrillation Patients With Heart Failure With Both Preserved and Reduced Left Ventricular Ejection Fraction

His Bundle Pacing Or Biventricular Pacing For Cardiac Resynchronization Therapy In Heart Failure: Discovering New Methods For An Old Problem

Cardiac Arrhythmias: Mechanistic Knowledge and Innovation from Computer Models

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