Ventricular rate smoothing for atrial fibrillation: a quantitative comparison study

Lian, Jie; Müßig, D; Lang, Volker

doi:10.1093/europace/eum088

Cited by 12 publications

(11 citation statements)

References 37 publications

(110 reference statements)

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“…Progressively shortening the BI (850ms, 750ms, 680ms, 600ms) leads to higher percentage of VP (respectively 28.8%, 59.6%, 75.6%, 92%) and increased stabilization of the ventricular rate. Consistent with previous findings [12], VP not only eliminates long ventricular pauses, but also suppresses short intrinsic RR intervals in AF.…”

Section: Model Applicationssupporting

confidence: 92%

“…First, an AF-VP model was developed to elucidate the effects of ventricular pacing (VP) on ventricular rhythm in AF [11]. Computer simulations have shown that the AF-VP model could account for most experimental observations, including various patterns of RR interval histograms in AF, [11] biphasic relationship between atrial and ventricular rates in AF, [11] the rate smoothing effects of VP in AF, [11][12][13] and many well-known AV conduction and refractory properties [14]. Second, by incorporating more realistic heart rhythm generators, bi-directional wave conductions, and an industry-standard dual-chamber pacemaker timing control logic into the AF-VP model, we have developed an integrated dual-chamber heart and pacer (IDHP) model, which provides an abstract yet realistic representation of the native cardiac electrical conduction system and its interactions with external cardiac pacing [15].…”

Section: Introductionmentioning

confidence: 99%

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Open Source Modeling of Heart Rhythm and Cardiac Pacing

Lian¹

2013

TOPETJ

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Background: Despite the progress of cardiac arrhythmia research and the advance of the pacemaker technology, much remains unknown about how the external pacing interacts with the heart's intrinsic activity. Methods: We present an open source computer model that is capable to simulate intrinsic heart rhythm under both normal and pathological conditions, and its interactions with extrinsic dual-chamber cardiac pacing. Detailed model structure and the software implementation are described. Results: We demonstrate the usage of the computer model for generating realistic cardiac activation sequences under different rhythm conditions. Representative examples are also provided to illustrate the application of the model to evaluate the performance of pacing algorithms. Conclusions: The present computer model provides a unified platform wherein it is possible to bench test advanced pacemaker algorithms in the presence of different heart rhythms. The availability of this open source model promises to support and stimulate future research in cardiac electrophysiology and development in pacemaker technology.

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Section: Model Applicationssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Open Source Modeling of Heart Rhythm and Cardiac Pacing

Lian¹

2013

TOPETJ

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“…It has been demonstrated that this model could explain most experimental observations, including various patterns of RR interval distribution in AF, 12 biphasic relationship between atrial and ventricular rates in AF, 12 and the rate stabilization effects of VP. 12,14, 15 We have further validated this model through simulated atrial pacing protocols, which are simpler-case scenarios by factoring out the randomness of AF and the interactions with VP. 13 To facilitate the use and further improvement of the AF-VP model, its software has been made freely available on PhysioNet (http://www.physionet.org/physiotools/afvp/).…”

Section: Prior Workmentioning

confidence: 99%

Heart Rhythm and Cardiac Pacing: An Integrated Dual-Chamber Heart and Pacer Model

Lian

Müßig

2008

Ann Biomed Eng

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Modern cardiac pacemaker can sense electrical activity in both atrium and ventricle, and deliver precisely timed stimulations to one or both chambers on demand. However, little is known about how the external cardiac pacing interacts with the heart's intrinsic activity. In this study, we present an integrated dual-chamber heart and pacer (IDHP) model to simulate atrial and ventricular rhythms in the presence of dual chamber cardiac pacing and sensing. The IDHP model is an extension and improvement of a previously developed open source model for simulating ventricular rhythms in atrial fibrillation and ventricular pacing. The new model takes into account more realistic properties of atrial and ventricular rhythm generators, as well as bi-directional conductions in atrium, ventricle, and the atrio-ventricular junction. Moreover, an industry-standard dual-chamber pacemaker timing control logic is incorporated in the model. We present examples to show that the new model can generate realistic cardiac rhythms in both physiologic and pathologic conditions, and simulate various interactions between intrinsic heart activity and extrinsic cardiac pacing. Among many applications, the IDHP model provides a new simulation platform where it is possible to bench test advanced pacemaker algorithms in the presence of different types of cardiac rhythms.

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“…One of the most influential papers in this research line was presented in 1983 by Cohen et al [67]. In this case, and in some more recent publications following the same approach [74,77,78,79], authors used Poisson processes to simulate atrial activity during AF and, by using their models, estimate the ventricular response pattern.…”

Section: Models Of the Rr Interval Seriesmentioning

confidence: 99%

“…In recent studies by Lian et al [74,77,78,79], authors illustrated the possibilities of ventricular pacing therapy as a rate control strategy during AF [3].…”

Section: Models Of the Rr Interval Seriesmentioning

confidence: 99%

Characterization and Modeling of Atrioventricular Conduction during Atrial Fibrillation

Climent¹,

Andreu²

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AgradecimientosLa consecución de la presente tesis hubiese sido completamente imposible sin la colaboración de numerosas personas que me han ayudado, enseñado y apoyado durante estos años. Quiero empezar agradeciendo el apoyo recibido por todos los integrantes del grupo de Bioingeniería del instituto ITACA de la Universidad Politécnica de Valencia desde que empecé a colaborar con ellos en 2005. De todos los que durante este tiempo han pasado por el laboratorio he aprendido muchísimo y tengo un más que grato recuerdo: Jose Luis Espí, José Laparra, Jose Antonio Belloch, Laura Maestro, Vicky Donis, Cinta Barber, Amparo Pomar, María Mozo, Lola Guerrero, Lydia Dux, Martina Srutova, Pietro Bonizzi, Lorena Rausell, Jesús Vila y Xavier Ibáñez. Y por supuesto quiero mandar un caluroso agradecimiento a todos con los que sigo trabajando día a día y de los que cada día aprendo nuevas cosas: Jorge Pedrón, Alejandro Liberos, Eduard Roses, Toni Guill, Alvaro Tormos, José Antonio Pérez, Toni Cebrián, Paco Castells, Conrado Calvo, Amador Ayala, María Vinaches, Cristina Rojas, Adolfo Fonseca, Jesús Escrivá y Miguel Rodrigo. Comentario a parte merece José Millet del cual he aprendido innombrables cosas y cuyo espíritu entusiasta y su capacidad de encajar los problemas con tranquilidad son virtudes que querría tener la capacidad de imitar y que me acompañasen durante el resto de mi carrera.Además del apoyo de todos los compañeros del laboratorio, la realización de las diversas estancias de investigación ha sido imprescindible para que esta tesis haya llegado a buen término. Junto con el Dr. Andreas Bollmann entré en el mundo de la ciencia, deél aprendí algunas de las lecciones más valiosas entre las que quiero destacar elímpetu por colaborar y aprender siempre con los mejores estuviesen en el laboratorio de al lado o a 5000km. Este afán por conseguir enriquecer nuestras investigaciones con el apoyo de algunos de los más reputados expertos del mundo me ha llevado a Milán junto con a la Dra. Valentina Corino y al Dr. Luca Mainardi, a Suecia con los Drs. Martin Stridth y Leif Srnmo, a Cleveland junto con los Drs. Youhua Zhang y Todor Mazgalev y a Michigan junto con los Drs. Omer Berenfeld y José Jalife. Cada una de esas estancias me ha enriquecido no sólo como investigador sino como persona. Poder colaborar con investigadores tan reputados a la vez que grandes personas ha sido un regalo que es difícil de describir en unas pocas palabras pero que viajará i ii AGRADECIMIENTOS conmigo el resto de mi vida. Junto con las colaboraciones internacionales, en mi por ahora corta carrera como investigador he tenido la suerte de trabajar con grandes investigadores españoles entre los que quiero destacar a los Drs. Felipe Atienza, Aurelio Quesada y Javier Chorro por confiar en nosotros pese a nuestra juventud, ayudarnos con nuestras limitaciones y descubrirnos la parte más humana de la práctica clínica y la investigación.En el futuro, ojalá tenga la suerte de poder seguir contando con la colaboración de todos estos magníficos científicos y espero ...

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Ventricular rate smoothing for atrial fibrillation: a quantitative comparison study

Cited by 12 publications

References 37 publications

Open Source Modeling of Heart Rhythm and Cardiac Pacing

Open Source Modeling of Heart Rhythm and Cardiac Pacing

Heart Rhythm and Cardiac Pacing: An Integrated Dual-Chamber Heart and Pacer Model

Characterization and Modeling of Atrioventricular Conduction during Atrial Fibrillation

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