Ventricular mechanics after repair of subarterial and perimembranous <scp>VSD</scp>s

Kwok, Sit-Yee; Yeung, Susanna; Li, Vivian Wing‐yi; Cheung, Yiu‐fai

doi:10.1111/eci.12852

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…Although this research demonstrated they have reduced myocardial strain, Ross and Ross Konno procedures have good long term results with a low incidence of heart failure (22). Numerous studies have demonstrated abnormal strain in a range of CHD populations, including ventricular septal defects (23), tetralogy of Fallot (12), and transposition of the great arteries (24), however the clinical significance of these findings is not always clear. In a heterogeneous adult population reduced GLS is an independent prognostic predictor of major adverse cardiac events, stronger even than LVEF (8), however whether this remains true in the Ross and Ross-Konno groups is yet to be explored.…”

Section: Editorial Commentarymentioning

confidence: 90%

Subclinical myocardial dysfunction and dyssynchrony after Ross or Ross-Konno procedure

Ellenberger

Negishi

2020

Transl Pediatr

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Section: Editorial Commentarymentioning

confidence: 90%

Subclinical myocardial dysfunction and dyssynchrony after Ross or Ross-Konno procedure

Ellenberger

Negishi

2020

Transl Pediatr

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“…This type of dysfunction has received little attention ( 70 ). Interestingly, patients with isolated VSD show signs of impaired RV function late after VSD closure, but to what extent the IVS contributes to this dysfunction has yet to be determined ( 71 , 72 ).…”

Section: The Phenotype Of Right Ventricular Dysfunctionmentioning

confidence: 99%

The right ventricle in tetralogy of Fallot: adaptation to sequential loading

Symakani

Genuchten²,

Zandbergen³

et al. 2023

Front. Pediatr.

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Right ventricular dysfunction is a major determinant of outcome in patients with complex congenital heart disease, as in tetralogy of Fallot. In these patients, right ventricular dysfunction emerges after initial pressure overload and hypoxemia, which is followed by chronic volume overload due to pulmonary regurgitation after corrective surgery. Myocardial adaptation and the transition to right ventricular failure remain poorly understood. Combining insights from clinical and experimental physiology and myocardial (tissue) data has identified a disease phenotype with important distinctions from other types of heart failure. This phenotype of the right ventricle in tetralogy of Fallot can be described as a syndrome of dysfunctional characteristics affecting both contraction and filling. These characteristics are the end result of several adaptation pathways of the cardiomyocytes, myocardial vasculature and extracellular matrix. As long as the long-term outcome of surgical correction of tetralogy of Fallot remains suboptimal, other treatment strategies need to be explored. Novel insights in failure of adaptation and the role of cardiomyocyte proliferation might provide targets for treatment of the (dysfunctional) right ventricle under stress.

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