Ventricular hypertrophy and left atrial dilatation persist and are associated with reduced survival after valve replacement for aortic stenosis

Abstract

Severe left ventricular hypertrophy with left atrial dilatation can develop from severe aortic stenosis, even without symptoms. These changes can persist, are associated with decreased long-term survival even after successful aortic valve replacement, and could be indications for early aortic valve replacement if supported by findings from an appropriate prospective study.

Aortic valve repair for insufficiency in older children offers unpredictable durability that may not be advantageous over a primary Ross operation

“…This technique is similar to logistic regression in that it allows for the detection and characterization of nonlinear trends for haemodynamic indices. All available datapoints for each patient are utilized, and rather than analysing the data in aggregate, it is adjusted for individual patients [12,13]. The non-linear models can then be used for multivariable regression analysis, in a manner similar to the time to reintervention analysis.…”

Diabetes Mellitus Impairs Left Ventricular Mass Regression after Surgical or Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis

“…As postoperative LVMR occurs within one year after AVR and left ventricular mass tends to become stable thereafter [4], echocardiographic data was collected preoperatively and 12 months after surgery. Pressure gradient across the aortic valve was calculated using a simplified Bernoulli equation.…”

“…It occurs early after surgery and continues up to 10 years [2]. However, persistent residual left ventricular hypertrophy is not uncommon despite successful AVR [4,5]. Suboptimal LVMR is known to be associated with late cardiac events and poor long-term outcomes [4,5].…”

“…However, persistent residual left ventricular hypertrophy is not uncommon despite successful AVR [4,5]. Suboptimal LVMR is known to be associated with late cardiac events and poor long-term outcomes [4,5]. From the physiological point-of-view, the majority of studies have focussed on patient-prosthesis mismatch, which is defined as the effective orifice area of a normally functioning prosthesis being too small for a patient's body size.…”

Prevalence, Predictors and Prognostic Implications of Residual Impairment of Functional Capacity After Transcatheter Aortic Valve Implantation

“…Patients with degenerative AS referred for transcatheter aortic valve implantation (TAVI) typically have advanced cardiac [2] and vascular [3] adverse remodeling that may not be completely reversible after valve replacement [2,4,5]. In addition, non-cardiovascular comorbidities are common in those patients [2].…”