Ventricular Fibrillation in the Hypothermic State

Shumacker, Harris B.; Riberi, A; Boone, R. D.; Kajikuri, H

doi:10.1097/00000658-195614320-00007

Cited by 2 publications

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“…We have to conclude that ventricular fibrillation is probably not only due to a gross disorganization of muscle groups, but more probably is the result of profound changes in the function of every cardiac cell and its membrane. Nervous and Humoral Control of the Heart The possible influence of the autonomic nervous system on the heart in relation to ventricular fibrillation has been investigated by Shumacker et al (1956). Bilateral upper dorsal sympathectomy and stellate ganglionectomy or blockade gave complete protection from ventricular fibrillation in a series of hypothermic dogs subjected to October I959 operative cardiac manipulation.…”

Section: Myocardial Excitabilitymentioning

confidence: 99%

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Ventricular Fibrillation in Induced Hypothermia

Caldini

1959

Postgraduate Medical Journal

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Section: Myocardial Excitabilitymentioning

confidence: 99%

“…Intravenous injection of sympathetic blocking drugs, such as Trimethaphen (Arfonad), was similarly effective, but to a lesser extent. Procaine block of the sinoauricular node has been shown to have a protective value, probably by interruption of sympathetic nerve supply to the heart (Riberi et al, 1956).…”

Section: Myocardial Excitabilitymentioning

confidence: 99%

Ventricular Fibrillation in Induced Hypothermia

Caldini

1959

Postgraduate Medical Journal

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Control of Spontaneous Ventricular Fibrillation during Induced Hypothermia in Cats by Acute Cardiac Sympathectomy

Nielsen

Owman

1969

Acta Physiologica Scandinavica

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17 adult cats were subjected to cardiac sympathectomy under nembutal anesthesia by bilateral excision of the cervical sympathetic chains between and including the superior cervical and stellate ganglia. Immediately after operation, the anesthetized animals were cooled by submersion in an ice‐water bath. Blood pressure, ECG, rectal temperature and respiration were continuously observed. Angiotensin was administered intermittently to maintain the blood pressure at an adequate level at the lower body temperatures. Artificial respiration was applied when indicated. Under these conditions, only 2 out of 17 denervated animals died in ventricular fibrillation, at 23 and 18.4o C rectal temperature. The remaining animals were cooled to 17.7–15o C and subsequently re‐warmed to normothermia without complications. All of 17 unoperated control animals subjected to hypothermia in the same way developed ventricular fibrillation. Cardiac noradrenaline determined fluorimetrically at the end of the experiments did not differ significantly between the two experimental groups. The results of the present and earlier investigations indicate that hypothermia activates the sympathetic system through a central mechanism and that the cardiac sympathetic nerves represent an important factor for the spontaneous development of ventricular fibrillation, a characteristic complication of induced deep hypothermia in homeothermic mammals.

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Ventricular Fibrillation in the Hypothermic State

Cited by 2 publications

References 0 publications

Ventricular Fibrillation in Induced Hypothermia

Ventricular Fibrillation in Induced Hypothermia

Control of Spontaneous Ventricular Fibrillation during Induced Hypothermia in Cats by Acute Cardiac Sympathectomy

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