Ventricular fibrillation in acute myocardial infarction in Spanish patients: Results of the ARIAM database*

Ruiz-Bailén, Manuel; Hoyos, Eduardo Aguayo de; Ruiz-Navarro, Silvia; Issa-Khozouz, Ziad; Reina-Toral, Antonio; Díaz-Castellanos, Miguel Ángel; Rodríguez-García, Juan-José; Torres-Ruiz, Juan Miguel; Cárdenas-Cruz, Antonio; Camacho-Víctor, Ángel

doi:10.1097/01.ccm.0000079602.14851.eb

Cited by 26 publications

(9 citation statements)

References 19 publications

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“…We found that despite their high-risk features, patients with pre-hospital cardiac arrest had lower rates of use of aspirin, clopidogrel, enoxaparin, β-blockers, ACE inhibitors, angiotensin receptor blockers, statin, and nitrates within the first 24 h of presentation. This finding is in agreement with similar research using different patient cohorts [10,22]. …”

Section: Discussionsupporting

confidence: 83%

“…We observed that male gender, current smoker status, tachycardia, ST-segment deviation, and higher Killip class were independently associated with pre-hospital cardiac arrest presentation in the setting of ACS. Smoking plays a role in the formation of acute thrombosis and is also associated with elevation of systemic inflammatory markers such as C-reactive protein, white blood cell count and fibrinogen [5,18,22]. These mechanisms may predispose smokers to cardiac arrest by inducing a greater degree of systemic inflammation and myocardial necrosis.…”

Section: Discussionmentioning

confidence: 99%

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Pre-Hospital Cardiac Arrest in Acute Coronary Syndromes: Insights from the Global Registry of Acute Coronary Events and the Canadian Registry of Acute Coronary Events

Goodman²,

Yan³

et al. 2013

Cardiology

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Objectives: Cardiac arrest in acute coronary syndromes (ACS) is associated with high morbidity and mortality. We examined the clinical characteristics, contemporary management patterns and outcomes of ACS patients with pre-hospital cardiac arrest. Methods: The Global Registry of Acute Coronary Events and the Canadian Registry of Acute Coronary Events enrolled 14,010 ACS patients in 1999-2008. We compared the clinical characteristics, in-hospital treatment and outcomes between patients with and without pre-hospital cardiac arrest. Results: Overall, 206 (1.4%) patients had cardiac arrest prior to hospital presentation. ACS patients with pre-hospital cardiac arrest were less frequently treated with aspirin, β-blocker, angiotensin-converting enzyme inhibitors, and statins within the first 24 h of presentation, but the use of cardiac procedures was similar compared to the group without cardiac arrest. Patients with pre-hospital cardiac arrest had significantly higher rates of in-hospital adverse events. Factors independently associated with pre-hospital cardiac arrest included male gender, current smoker status, tachycardia, higher Killip class and ST-segment deviation. Conclusion: ACS patients with pre-hospital cardiac arrest continue to have more in-hospital complications and higher mortality. Their use of evidence-based medical therapies was lower but the use of cardiac procedures was similar compared to the group without cardiac arrest. Better utilization of evidence-based therapies in these patients may translate into improved outcomes.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Pre-Hospital Cardiac Arrest in Acute Coronary Syndromes: Insights from the Global Registry of Acute Coronary Events and the Canadian Registry of Acute Coronary Events

Goodman²,

Yan³

et al. 2013

Cardiology

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“…2–7 Our rates of these life-threatening arrhythmias are also better than rates in contemporary cohorts: 4.3%–10.2% for VT/ventricular fibrillation combined, 12,14,20 2.6%–6% for VT 21–23 and 3.5–5.4% for ventricular fibrillation. 23,24 Our better rates may be attributed to patients having smaller infarctions and fewer ensuing complications from electrical and pump malfunction.…”

Section: Discussionmentioning

confidence: 98%

Arrhythmias in patients with acute coronary syndrome in the first 24 hours of hospitalization

et al. 2013

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Objectives In patients with acute coronary syndrome (ACS), we sought to: 1) describe arrhythmias during hospitalization, 2) explore the association between arrhythmias and patient outcomes, and 3) explore predictors of the occurrence of arrhythmias. Methods In a prospective sub-study of the IMMEDIATE AIM study, we analyzed electrocardiographic (ECG) data from 278 patients with ACS. On emergency department admission, a Holter recorder was attached for continuous 12-lead ECG monitoring. Results Approximately 22% of patients had more than 50 premature ventricular contractions (PVCs) per hour. Non-sustained ventricular tachycardia (VT) occurred in 15% of patients. Very few patients (≤1%) had a malignant arrhythmia (sustained VT, asystole, torsade de pointes, or ventricular fibrillation). Only more than 50 PVCs/hour independently predicted an increased length of stay (p<.0001). No arrhythmias predicted mortality. Age greater than 65 years and a final diagnosis of acute myocardial infarction independently predicted more than 50 PVCs per hour (p=.0004). Conclusions Patients with ACS seem to have fewer serious arrhythmias today, which may have implications for the appropriate use of continuous ECG monitoring.

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“…The size of ischemic area is not the absolute potential risk factors associated with ventricular arrhythmia. Other factors as young age, female gender, absence of diabetes history and inferior infarct location had been reported to be potential risk factors for primary ventricular fibrillation in acute MI [3, 4]. The leading factors of lethal arrhythmia in acute MI are inconsistent in different studies.…”

Section: Discussionmentioning

confidence: 99%

Sudden Cardiac Death in a Case of Non-Dominant Coronary Artery Obstruction Without Depressed Left Ventricular Function

Chen

2013

Cardiol Res

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Acute myocardial infarction complicated with lethal cardiac arrhythmia remains the major cause of sudden death. The possible clinical presentation leading to lethal ventricular arrhythmia has been demonstrated but the data are limited. The previous study revealed no significant correlation between sudden cardiac death and the location of coronary obstruction site. And the possible mechanism of sudden cardiac death in non-dominant coronary artery obstruction is unclear. We presented a case of acute myocardial infarction with mid left circumflex artery occlusion complicated with new onset atrial fibrillation initially. The rhythm degenerated into ventricular fibrillation immediately and sudden cardiac death occurred. After resuscitation, he received coronary angioplasty, and the rhythm recovered to sinus after the occluded coronary artery reopened. We thick new onset atrial fibrillation could be a potential risk factor leading to sudden death in acute myocardial infarction with obstruction of non-dominant coronary artery. Control of ventricular rate and early restoration of sinus rhythm may be potential benefit.

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Ventricular fibrillation in acute myocardial infarction in Spanish patients: Results of the ARIAM database*

Abstract: Despite the considerable improvement in the treatment of AMI in recent years, the onset of either primary or secondary VF is associated with a poor prognosis. It is usually accompanied by extensive necrosis.

Cited by 26 publications

References 19 publications

Pre-Hospital Cardiac Arrest in Acute Coronary Syndromes: Insights from the Global Registry of Acute Coronary Events and the Canadian Registry of Acute Coronary Events

Pre-Hospital Cardiac Arrest in Acute Coronary Syndromes: Insights from the Global Registry of Acute Coronary Events and the Canadian Registry of Acute Coronary Events

Arrhythmias in patients with acute coronary syndrome in the first 24 hours of hospitalization

Sudden Cardiac Death in a Case of Non-Dominant Coronary Artery Obstruction Without Depressed Left Ventricular Function

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