Ventricular Fibrillation in a General Population　– A National Database Study –

Tseng, Wei‐Chieh; Wu, Mei‐Hwan; Chen, Hui‐Chi; Kao, Feng-Yu; Huang, San‐Kuei

doi:10.1253/circj.cj-16-0602

Cited by 12 publications

(8 citation statements)

References 39 publications

(12 reference statements)

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“…The prevalence of ventricular fibrillation can be surmised to be 6,3 cases/100,000 inhabitants ( 81 ). The incidence of ventricular fibrillation is about 1.83 per 10,000 inhabitants ( 82 ).…”

Section: Cardiovascular Diseases Managementmentioning

confidence: 99%

Management of Cardiovascular Disease in Patients With COVID-19 and Chronic Chagas Disease: Implications to Prevent a Scourge Still Larger

Bestetti

Bocchi²,

Bestetti³

et al. 2022

Front. Med.

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Cardiovascular diseases (CVD) are the most important cause of morbidity and mortality in the general population. Because the high prevalence of COVID-19 and chronic Chagas disease (CCD) where the latter is endemic, all such diseases will likely be observed in the same patient. While COVID-19 can provoke generalized endotheliitis, which can lead to a cytokine storm and a hyper-coagulable state culminating into in-site and at a distance thrombosis. Therefore, small-vessel coronary artery disease (CAD), cerebrovascular disease, thromboembolism, and arrhythmias are prominent findings in COVID-19. In CCD, small-vessel CAD, cardioembolic stroke, pulmonary embolism, heart failure and arrhythmias are frequently observed as a result of a similar but less intense mechanism. Consequently, the association of CCD and COVID-19 will likely increase the incidence of CVD. Thus, doctors on the frontline should be on the alert for this diagnostic possibility so that the proper treatment can be given without any delay.

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Section: Cardiovascular Diseases Managementmentioning

confidence: 99%

Management of Cardiovascular Disease in Patients With COVID-19 and Chronic Chagas Disease: Implications to Prevent a Scourge Still Larger

Bestetti

Bocchi²,

Bestetti³

et al. 2022

Front. Med.

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“…However, ∼4% arise from congenital ion channel abnormalities 3,4 . Most clinical arrhythmias show higher male than female incidences through all age groups, differences further increasing with age 5,6 …”

Section: Introductionmentioning

confidence: 99%

“…3,4 Most clinical arrhythmias show higher male than female incidences through all age groups, differences further increasing with age. 5,6 Of inherited arrhythmic syndromes, catecholaminergic polymorphic ventricular tachycardia (CPVT) affects 1 in 10,000 individuals. It is characterized by potentially fatal ventricular arrhythmic episodes, often biventricular or polymorphic ventricular tachycardia and VF, following adrenergic challenge precipitated by emotional or physical stress.…”

Section: Introductionmentioning

confidence: 99%

Protein expression profiles in murine ventricles modeling catecholaminergic polymorphic ventricular tachycardia: effects of genotype and sex

Saadeh

Achercouk

Fazmin

et al. 2020

Annals of the New York Academy of Sciences

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Catecholaminergic polymorphic ventricular tachycardia (CPVT) is associated with mutations in the cardiac ryanodine receptor (RyR2). These result in stress-induced ventricular arrhythmic episodes, with clinical symptoms and prognosis reported more severe in male than female patients. Murine homozygotic RyR2-P2328S (RyR2 S/S) hearts replicate the proarrhythmic CPVT phenotype of abnormal sarcoplasmic reticular Ca 2+ leak and disrupted Ca 2+ homeostasis. In addition, RyR2 S/S hearts show decreased myocardial action potential conduction velocities (CV), all features implicated in arrhythmic trigger and substrate. The present studies explored for independent and interacting effects of RyR2 S/S genotype and sex on expression levels of molecular determinants of Ca 2+ homeostasis (CASQ2, FKBP12, SERCA2a, NCX1, and Ca V 1.2) and CV (Na V 1.5, Connexin (Cx)-43, phosphorylated-Cx43, and TGF-β1) in mice. Expression levels of Ca 2+ homeostasis proteins were not altered, hence implicating abnormal RyR2 function alone in disrupted cytosolic Ca 2+ homeostasis. Furthermore, altered Na V 1.5, phosphorylated Cx43, and TGF-β1 expression were not implicated in the development of slowed CV. By contrast, decreased Cx43 expression correlated with slowed CV, in female, but not male, RyR2 S/S mice. The CV changes may reflect acute actions of the increased cytosolic Ca 2+ on Na V 1.5 and Cx43 function.

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“…Neonatal ventricular tachycardias including ventricular fibrillation are extremely rare 5 and can be fatal without defibrillation if the ventricular rate is high 6 .…”

mentioning

confidence: 99%

“…4 Even though infrequent and brief episodes may be closely monitored, 2 persistent or symptomatic atrial flutter may need cardioversion. 2,3 Neonatal ventricular tachycardias including ventricular fibrillation are extremely rare 5 and can be fatal without defibrillation if the ventricular rate is high. 6 Many arrhythmias are diagnosed and treated by a neonatologist or pediatrician prior to presenting to a pediatric cardiologist.…”

mentioning

confidence: 99%

A Survey of Academic Neonatologists on Neonatal Electrical Cardioversion and Defibrillation

et al. 2023

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Objective: Assess neonatologists’ experience and comfort with neonatal electrical cardioversion or defibrillation (EC-D). Study Design: Electronic surveys were distributed to academic neonatologists affiliated with 12 Midwest academic hospitals. Neonatologists were asked about their residency training; years since completing residency; current certification/ competency training in BLS, PALS, ACLS and NRP; experiences with EC-D; availability of a pediatric cardiologist and their comfort levels with such procedures. Standard statistical tests evaluated comfort with EC-D. Results: Seventy-two out of 180 neonatologists responded to the survey (response rate=40%). 98.6% (71), 54.2% (39) and 37.5% (27) maintained current NRP, BLS and PALS training respectively. 73.6% (n=53) reported having performed neonatal EC-D. Of those, 50.9% (n=27) indicated feeling slightly to very uncomfortable performing EC-D. We report a lack of BLS certification being associated with lack of comfort (OR: 0.269 - 95% CI [0.071, 0.936]), and a positive association between a pediatric cardiologist being present and being uncomfortable (OR: 3.722 – 95% CI [1.069,14.059]). Those reporting greater volume and more recent experience with EC-D report more comfort. Conclusion: Of neonatologists that performed EC-D, half reported being uncomfortable. BLS certification and experience are positively associated with comfort in performing EC-D. Simulations to increase training in EC-D should be offered regularly to academic neonatologists.

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Ventricular Fibrillation in a General Population　– A National Database Study –

Cited by 12 publications

References 39 publications

Management of Cardiovascular Disease in Patients With COVID-19 and Chronic Chagas Disease: Implications to Prevent a Scourge Still Larger

Management of Cardiovascular Disease in Patients With COVID-19 and Chronic Chagas Disease: Implications to Prevent a Scourge Still Larger

Protein expression profiles in murine ventricles modeling catecholaminergic polymorphic ventricular tachycardia: effects of genotype and sex

A Survey of Academic Neonatologists on Neonatal Electrical Cardioversion and Defibrillation

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Ventricular Fibrillation in a General Population – A National Database Study –

Cited by 12 publications

References 39 publications

Management of Cardiovascular Disease in Patients With COVID-19 and Chronic Chagas Disease: Implications to Prevent a Scourge Still Larger

Management of Cardiovascular Disease in Patients With COVID-19 and Chronic Chagas Disease: Implications to Prevent a Scourge Still Larger

Protein expression profiles in murine ventricles modeling catecholaminergic polymorphic ventricular tachycardia: effects of genotype and sex

A Survey of Academic Neonatologists on Neonatal Electrical Cardioversion and Defibrillation

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Product

Resources

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Ventricular Fibrillation in a General Population　– A National Database Study –