Ventricular dilation on CAT scans of patients with anorexia nervosa

Datlof, S; Pd, Coleman; Gb, Forbes; Re, Kreipe

doi:10.1176/ajp.143.1.96

Cited by 46 publications

(2 citation statements)

References 6 publications

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“…Overall GM alterations are reversible after weight restoration, but it is still not clear whether reversibility is complete 9–19. Pathogenetic mechanisms of cerebral alterations are not still completely explained and current hypotheses include: i) decreased serum proteins resulting in decreased colloidal osmotic pressure and a shift of fluid from the intravascular space into the subarachnoid spaces;20 ii) partial regeneration of damaged neurons and their axons with possible regeneration of myelin;21 iii) loss of lean body tissue mass;22 iv) increased urine and serum cortisol levels;23 and v) decreased protein synthesis resulting in loss of dendritic spines, a reduction in the number of synaptic junctions, and delayed synaptogenesis 10…”

Section: Introductionmentioning

confidence: 99%

Global and regional brain volumes normalization in weight-recovered adolescents with anorexia nervosa: preliminary findings of a longitudinal voxel-based morphometry study

Bomba¹,

Riva²,

Morzenti³

et al. 2015

NDT

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The recent literature on anorexia nervosa (AN) suggests that functional and structural abnormalities of cortico-limbic areas might play a role in the evolution of the disease. We explored global and regional brain volumes in a cross-sectional and follow-up study on adolescents affected by AN. Eleven adolescents with AN underwent a voxel-based morphometry study at time of diagnosis and immediately after weight recovery. Data were compared to volumes carried out in eight healthy, age and sex matched controls. Subjects with AN showed increased cerebrospinal fluid volumes and decreased white and gray matter volumes, when compared to controls. Moreover, significant regional gray matter decrease in insular cortex and cerebellum was found at time of diagnosis. No regional white matter decrease was found between samples and controls. Correlations between psychological evaluation and insular volumes were explored. After weight recovery gray matter volumes normalized while reduced global white matter volumes persisted.

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Section: Introductionmentioning

confidence: 99%

Global and regional brain volumes normalization in weight-recovered adolescents with anorexia nervosa: preliminary findings of a longitudinal voxel-based morphometry study

Bomba¹,

Riva²,

Morzenti³

et al. 2015

NDT

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“…First hypothesis that volume reductions are related to neuron death has not been confirmed either by neuro-biochemical [17], histological studies [18] or by improvement of brain alterations with weight restoration [10]. The current hypothesis, summarized in Swayze’s study [8], include: i) decreased serum proteins resulting in decreased colloidal osmotic pressure and a shift of fluid from the intravascular space into the subarachnoid spaces [19]; ii) partial regeneration of damaged neurons and their axons with possible regeneration of myelin [20]; iii) loss of lean body tissue mass [21]; iv) increased urine and serum cortisol levels [22]; v) decreased protein synthesis resulting in loss of dendritic spines, a reduction in the number of synaptic junctions, and delayed synaptogenesis [7]. …”

Section: Introductionmentioning

confidence: 99%

Impact of speed and magnitude of weight loss on the development of brain trophic changes in adolescents with anorexia nervosa: a case control study

et al. 2013

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BackgroundAnorexia nervosa commonly arises during adolescence and is associated with more than one medical morbidity. Abnormalities in brain structure (defined as “pseudoatrophy”) are common in adolescents with anorexia nervosa; however, their correlations with endocrinological profiles and clinical parameters are still unclear. In particular, no study has described the impact of BMI (body mass index) variations (speed and magnitude of weight loss) on cerebral trophism changes.MethodsEleven adolescents with anorexia nervosa and 8 healthy controls underwent cerebral MRI (magnetic resonance imaging) examination to obtain global and partial volumes (gray matter, white matter and cerebrospinal fluid) and clinical evaluation. The Mann-Whitney U test was used to compare partial volumes and clinical variables between cases and controls. The Spearman non-parametric test was performed in order to explore correlations between the variables studied.ResultsThe patients diagnosed with AN showed significantly increased cerebrospinal fluid (CSF) volumes and decreased total gray (GM) and white matter (WM) volumes. The degree of weight loss (deltaBMI) correlated inversely with the GM volume; the increase of CSF compartment correlated directly with the rapidity of weight loss (DeltaBMI/disease duration).ConclusionsThis study suggests a correlation between cerebral alterations in AN and the speed and magnitude of weight loss, and outlines its importance for the therapeutic treatment.

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A Longitudinal Magnetic Resonance Imaging Study of Brain Changes in Adolescents With Anorexia Nervosa

Katzman

Zipursky²,

Lambe³

et al. 1997

Arch Pediatr Adolesc Med

127

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Ventricular dilation on CAT scans of patients with anorexia nervosa

Cited by 46 publications

References 6 publications

Global and regional brain volumes normalization in weight-recovered adolescents with anorexia nervosa: preliminary findings of a longitudinal voxel-based morphometry study

Global and regional brain volumes normalization in weight-recovered adolescents with anorexia nervosa: preliminary findings of a longitudinal voxel-based morphometry study

Impact of speed and magnitude of weight loss on the development of brain trophic changes in adolescents with anorexia nervosa: a case control study

A Longitudinal Magnetic Resonance Imaging Study of Brain Changes in Adolescents With Anorexia Nervosa

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