Ventricular Diastolic Function of Ankylosing Spondylitis Patients by Using Conventional Pulsed Wave Doppler, Myocardial Performance Index and Tissue Doppler Imaging

Abstract

When sensitive echocardiographic Doppler techniques such as MPI, TDI-derived MPI, and PW-TDI are utilized, DD can be detected in a significant proportion of patients with AS without cardiovascular (CV) disease which may contribute CV mortality in these patients.

Prevalence of diastolic dysfunction in patients with ankylosing spondylitis: a cross-sectional study

“…In a study of 49 patients with AS (mean age 38 AE 11 years), Okan et al (15) detected a significant proportion of patients with DD without cardiovascular disease. An é/á ratio < 1.0 was observed in 45% of the patients.…”

“…Abnormalities in left ventricular (LV) diastolic dysfunction (DD) have also been observed in patients with AS (12)(13)(14)(15). However, these previous studies have reported varying incidences of DD, which may be related to the use of different imaging modalities.…”

Increased Levels of Asymmetric Dimethylarginine (ADMA) in Patients with Ankylosing Spondylitis

“…The severity of cardiac involvement varies greatly ranging from asymptomatic to severe considerable problems such as severe heart failure, and arrhythmias (3). Some studies revealed an increased prevalence of cardiovascular (CV) mortality in AS (4)(5)(6)(7)(8).…”

Biphasic Pulmonary Regurgitation

“…Figure 4 shows the tissue Doppler recording at the level of the lateral tricuspid annulus. The reduced early (E ) diastolic myocardial relaxation velocity combined with the reduced ratio of E to the late (A ) velocities (<1) 6,7 indicate the presence of right ventricular diastolic dysfunction in our patient. Another potential contributing factor could be the development of diastolic tricuspid regurgitation causing reduction of end diastolic right ventricular pressure and reestablishment of the gradient between the pulmonary artery and the right ventricle.…”