Ventricular Arrhythmias and Sudden Cardiac Death in End-Stage Renal Disease Patients on Chronic Hemodialysis

Meier, Pascal; Vogt, Paul; Blanc, Edouard

doi:10.1159/000045917

Cited by 61 publications

(53 citation statements)

References 78 publications

(118 reference statements)

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“…The latter trial demonstrated a trend toward reduction in sudden death mortality for patients who were treated with the BBL carvedilol, an observation that is supported and extended by the current study. BBL may attenuate the effects of excess catecholamine release and improve electrocardiographic abnormalities that occur during a dialysis session, leading to an increased chance for successful resuscitation (illustrated by decreased odds of death at 24 h) and protection against subsequent events (illustrated by a decreased odds of death at 6 mo) (28,38).…”

Section: Factors That Influence Survival After Camentioning

confidence: 99%

Predictors of Survival after Cardiac Arrest in Outpatient Hemodialysis Clinics

Pun

Lehrich

Smith

et al. 2007

Clinical Journal of the American Society of Nephrology

108

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Section: Factors That Influence Survival After Camentioning

confidence: 99%

Predictors of Survival after Cardiac Arrest in Outpatient Hemodialysis Clinics

Pun

Lehrich

Smith

et al. 2007

Clinical Journal of the American Society of Nephrology

108

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“…Cardiac arrhythmias and cardiac deaths are common in dialysis patients of all ages but are particularly problematic in patients who are older than 65 yr (21). There are many potential reasons for the problem of sudden death: Abnormalities in the coronary microcirculation; impaired coronary reserve; reduced aortic compliance; increased activity of the sympathetic nervous system; the increased plasma concentration of angiotensin II; and sudden changes in the concentrations of potassium, calcium, and magnesium (which occur normally during dialysis) all can contribute to this problem.…”

Section: Overview Of the Problem Of Cardiovascular Disease In Patientmentioning

confidence: 99%

Kidney-Heart Interactions

Berl

Henrich

2006

Clinical Journal of the American Society of Nephrology

187

121

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“…7 According to the US Renal Data System, Ϸ22% of all deaths are caused by SCD, and the incidence increases with age: 2% per year for ages 20 to 44 years, 3.7% per year for ages 45 to 64 years, and 7% per year for ages 65 years and older. 7,8 Despite the high risk for SCD in patients with end-stage renal disease, few studies have evaluated the association between less severe reductions in kidney function and SCD incidence. Two recent studies found that chronic kidney disease was associated with increased SCD risk among subjects with advanced heart failure who were enrolled in clinical trials involving implantable cardioverterdefibrillators.…”

mentioning

confidence: 99%

Kidney Dysfunction and Sudden Cardiac Death Among Women With Coronary Heart Disease

et al. 2008

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Abstract-We evaluated the association between kidney dysfunction and sudden cardiac death risk among ambulatory women with coronary heart disease. The Heart and Estrogen Replacement Study evaluated the effects of hormone treatment on cardiovascular events among 2763 postmenopausal women with coronary heart disease. Kidney dysfunction was categorized by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease equation. Multivariate proportional hazards models were used to adjust for cardiovascular risk factors, congestive heart failure, and myocardial infarction. At baseline, 37% (nϭ1027) had an eGFR of Ͼ60 mL/min, 54% (nϭ1503) had an eGFR of 40 to 60 mL/min, and 8% (nϭ230) had an eGFR of Ͻ40 mL/min. During the 6.8-year follow-up period, there were 136 adjudicated sudden cardiac deaths. The rate of sudden cardiac death was higher in those with lower kidney function (0.5% per year among those with an eGFR Ͼ60; 0.6% per year with an eGFR between 40 and 60; and 1.7% per year with an eGFR Ͻ40 mL/min; P for trend Ͻ0.001). After multivariate analysis with baseline risk factors, eGFR at 40 to 60 mL/min was not a significant predictor, but eGFR at Ͻ40 mL/min remained strongly associated with sudden cardiac death (hazard ratio: 3.2; 95% CI: 1.9 to 5.3); adjustment for incident congestive heart failure and myocardial infarction during follow-up diminished this association (hazard ratio: 2.3; 95% CI: 1.3 to 3.9), suggesting that congestive heart failure and myocardial infarction mediated only part of the association between kidney dysfunction and sudden cardiac death. Advanced kidney dysfunction is an independent predictor of sudden cardiac death among women with coronary heart disease. Key Words: kidney dysfunction Ⅲ women Ⅲ sudden cardiac death S udden cardiac death (SCD) is an important clinical and public health problem: Ͼ450 000 Americans died in 1998 from SCD, defined as a sudden pulseless death attributed to cardiovascular disease occurring outside of the hospital. 1 The proportion of cardiovascular deaths caused by SCD has increased over time, as have absolute rates of SCD among women aged 35 to 44 years. 2 The presence and severity of underlying heart disease, including coronary heart disease, chronic heart failure, and depressed left ventricular ejection fraction, are the most predictive risk factors for the future occurrence of SCD. [3][4][5][6] In addition, 1 population-based study among women has demonstrated an association between traditional coronary heart disease risk factors and SCD. 2 Another population at high risk for SCD are persons with end-stage renal disease. 7 According to the US Renal Data System, Ϸ22% of all deaths are caused by SCD, and the incidence increases with age: 2% per year for ages 20 to 44 years, 3.7% per year for ages 45 to 64 years, and 7% per year for ages 65 years and older. 7,8 Despite the high risk for SCD in patients with end-stage renal disease, few studies have evaluated the association between less severe reductions in kidney function and SCD...

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Ventricular Arrhythmias and Sudden Cardiac Death in End-Stage Renal Disease Patients on Chronic Hemodialysis

Cited by 61 publications

References 78 publications

Predictors of Survival after Cardiac Arrest in Outpatient Hemodialysis Clinics

Predictors of Survival after Cardiac Arrest in Outpatient Hemodialysis Clinics

Kidney-Heart Interactions

Kidney Dysfunction and Sudden Cardiac Death Among Women With Coronary Heart Disease

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