Ventricular arrhythmia management in patients with genetic cardiomyopathies

Sharif, Zain; Lubitz, Steven A.

doi:10.1016/j.hroo.2021.10.009

Cited by 1 publication

(1 citation statement)

References 179 publications

(192 reference statements)

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“…In addition, in ACM, specific mutations may correlate with earlier manifestation phenotypes and may influence risk stratification and management [ 74 ]. Considering the prognostic profile of gene positivity, the identification of some pathogenic mutations may help decision making about primary ICD implantation [ 99 ]. With regard to non-desmosomal gene defects, the TMEM43 p.S358L founder mutation is almost fully penetrant and highly lethal among male carriers and should be to be considered by itself an indication of prophylactic ICD [ 100 ].…”

Section: The World Of Acm and Dcm: How “Complex Imaging” (Electroanat...mentioning

confidence: 99%

Personalized Management of Sudden Death Risk in Primary Cardiomyopathies: From Clinical Evaluation and Multimodality Imaging to Ablation and Cardioverter-Defibrillator Implant

Lazzeroni,

Crocamo,

Ziveri

et al. 2023

JPM

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Sudden cardiac death represents the leading cause of death worldwide; although the majority of sudden deaths occur in an elderly population with coronary artery disease, some occur in young and otherwise healthy individuals, as is the case of cardiomyopathies. The aim of the present review is to provide a stepwise hierarchical approach for the global sudden death risk estimation in primary cardiomyopathies. Each individual risk factor is analyzed for its contribution to the overall risk of sudden death for each specific cardiomyopathy as well as across all primary myocardial diseases. This stepwise hierarchical and personalized approach starts from the clinical evaluation, subsequently passes through the role of electrocardiographic monitoring and multimodality imaging, and finally concludes with genetic evaluation and electro-anatomical mapping. In fact, the sudden cardiac death risk assessment in cardiomyopathies depends on a multiparametric approach. Moreover, current indications for ventricular arrhythmia ablation and defibrillator implantation are discussed.

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Section: The World Of Acm and Dcm: How “Complex Imaging” (Electroanat...mentioning

confidence: 99%