Ventral subiculum regulates hypothalamo–pituitary–adrenocortical and behavioural responses to cognitive stressors

Herman, James P.; Dolgas, C. Mark; Carlson, Sonia L.

doi:10.1016/s0306-4522(98)00055-4

Cited by 171 publications

(117 citation statements)

References 45 publications

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“…In particular, Hoover and Vertes described a significantly greater projection from the RE to the ventral (than to the dorsal) half of intermediate CA1 and subiculum. This is noteworthy in light of the present results showing a robust input to the LHAjd from the same region of the hippocampal formation, and in light of studies indicating a role for the ventral half of the hippocampal formation in defensive and anxiety-associated stress responses (e.g., Herman et al, 2006;Pentkowski et al, 2006). Furthermore, projections to the HPF arise more numerously from neurons located in the medial half of the RE, whereas the lateral RE is the predominant source of RE output to the prefrontal cortex (Hoover and Vertes, 2011a).…”

Section: Cerebrospinal Trunk: Sensory Systemsupporting

confidence: 72%

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

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The connections of the lateral hypothalamic area juxtadorsomedial region (LHAjd) were investigated in a series of pathway-tracing experiments involving iontophoretic co-injection of the tracers Phaseolus vulgaris-leucoagglutinin (PHA-L; for outputs) and cholera toxin B subunit (CTB; for inputs). Results revealed that the LHAjd has connections with some 318 distinct gray matter regions encompassing all four subsystems-motor, sensory, cognitive, and behavioral state -included in a basic structure-function network model of the nervous system. Integration of these subsystems is necessary for the coordination and control of emotion and behavior, and in that regard the connections of the LHAjd indicate that it may have a prominent role. Furthermore, the LHAjd connections, together with the connections of other LHA differentiations studied similarly to date, indicate a distinct topographic organization that suggests each LHA differentiation has specifically differing degrees of involvement in the control of multiple behaviors. For the LHAjd, its involvement to a high degree in the control of defensive behavior, and to a lesser degree in the control of other behaviors, including ingestive and reproductive, is suggested. Moreover, the connections of the LHAjd suggest that its possible role in the control of these behaviors may be very broad in scope because they involve the somatic, neuroendocrine, and autonomic divisions of the nervous system. In addition, we suggest that connections between LHA differentiations may provide, at the level of the hypothalamus, a neuronal substrate for the coordinated control of multiple themes in the behavioral repertoire. INDEXING TERMShypothalamus; periaqueductal gray; hippocampal formation; behavior; motivation An emerging view of the lateral hypothalamic area (LHA) reveals a highly regionally differentiated neuronal architecture with correspondingly differentiated axonal connections characterized by an extensive divergent and convergent topographic organization (Swanson, 2004;Goto et al., 2005;Swanson et al., 2005;Hahn, 2010;Hahn and Swanson, 2010). Such an organization calls for an equivalently extensive comparative analysis of the underlying organization of the severally parceled LHA (16 provisional LHA regions within the hypothalamic lateral zone) (Swanson, 2004). In a previous article (Hahn and Swanson, 2010), we presented the results of a high-resolution analysis of the axonal inputs and outputs of the lateral hypothalamic area (LHA) juxtaparaventricular (LHAjp) and suprafornical (LHAs) regions-two differentiations of the hypothalamic lateral zone middle group within NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript respectively a medial (LHAjp) and perifornical (LHAs) tier of a recently revised parcellation for the LHA (Swanson, 2004;Swanson et al., 2005).The previous work showed that the LHAjp and LHAs have interregional connections with several hundred distinct gray matter regions encompassing all four subsystems (motor, sensory, cognitive, and...

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Section: Cerebrospinal Trunk: Sensory Systemsupporting

confidence: 72%

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

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“…84,85 The CA1v is also a part of anxiety-related brain circuit, projecting to the BLA and exhibiting increased c-Fos expression after exposure to mild stress. 49,86,87 The CA1 role in modulating anxietyrelated behavior was also revealed by lesions specific to the ventral hippocampus, causing reduction in anxiety-like behavior.…”

Section: Discussionmentioning

confidence: 99%

Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits

et al. 2009

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The urocortin (Ucn) family of neuropeptides is suggested to be involved in homeostatic coping mechanisms of the central stress response through the activation of corticotropin-releasing factor receptor type 2 (CRFR2). The neuropeptides, Ucn1 and Ucn2, serve as endogenous ligands for the CRFR2, which is highly expressed by the dorsal raphe serotonergic neurons and is suggested to be involved in regulating major component of the central stress response. Here, we describe genetically modified mice in which both Ucn1 and Ucn2 are developmentally deleted. The double knockout mice showed a robust anxiolytic phenotype and altered hypothalamic-pituitary-adrenal axis activity compared with wild-type mice. The significant reduction in anxiety-like behavior observed in these mice was further enhanced after exposure to acute stress, and was correlated with the levels of serotonin and 5-hydroxyindoleacetic acid measured in brain regions associated with anxiety circuits. Thus, we propose that the Ucn/ CRFR2 serotonergic system has an important role in regulating homeostatic equilibrium under challenge conditions.

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“…However it is unclear whether the posterior medial BST specifically regulates fear and anxiety responses. The excitatory effects of posterior medial BST lesions on HPA axis responses to acute stress are similar to those seen following lesions of the ventral subiculum (Herman et al, 1998) and medial prefrontal cortex (Figueiredo et al, 2003), raising the possibility that the BST may relay information from these structures to the PVN. In the case of the ventral subiculum, anatomical interconnections with the PVN via this portion of the BST have been previously established (Cullinan et al, 1993).…”

Section: Discussionmentioning

confidence: 81%

The role of the posterior medial bed nucleus of the stria terminalis in modulating hypothalamic–pituitary–adrenocortical axis responsiveness to acute and chronic stress

Choi¹,

Furay²,

Evanson³

et al. 2008

Psychoneuroendocrinology

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SummaryThe bed nucleus of the stria terminalis (BST) plays a prominent role in brain integration of acute responses to stressful stimuli. This study tests the hypothesis that the BST plays a complementary role in regulation of physiological changes associated with chronic stress exposure. Male SpragueDawley rats received bilateral ibotenate lesions or sham lesions of the posterior medial region of the BST (BSTpm), an area known to be involved in inhibition of HPA axis responses to acute stress. Chronic stress was induced by 14-day exposure to twice daily stressors in an unpredictable sequence (chronic variable stress (CVS)). On the morning after the end of CVS, stressed and nonstressed controls were exposed to a novel restraint stress challenge. As previously documented, CVS caused adrenal hypertrophy, thymic involution, and attenuated body weight gain. None of these endpoints were affected by BSTpm lesions. Chronic stress exposure facilitated plasma corticosterone responses to the novel restraint stress and elevated CRH mRNA. Lesions of the BSTpm increased novel stressor-induced plasma ACTH and corticosterone secretion and enhanced c-fos mRNA induction in the paraventricular nucleus of the hypothalamus (PVN). In addition, lesion of the BSTpm resulted in an additive increase in CVS-induced facilitation of corticosterone responses and PVN CRH expression. Collectively these data confirm that the BSTpm inhibits HPA responses to acute stress, but do not strongly support an additional role for this region in limiting HPA axis responses to chronic drive. The data further suggest that acute vs. chronic stress integration are subserved by different brain circuitry.

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Ventral subiculum regulates hypothalamo–pituitary–adrenocortical and behavioural responses to cognitive stressors

Cited by 171 publications

References 45 publications

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits

The role of the posterior medial bed nucleus of the stria terminalis in modulating hypothalamic–pituitary–adrenocortical axis responsiveness to acute and chronic stress

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