Ventral striatal activation during attribution of stimulus saliency and reward anticipation is correlated in unmedicated first episode schizophrenia patients

Esslinger, Christine; Englisch, Susanne; Inta, Dragoš; Rausch, Franziska; Schirmbeck, Frederike; Mier, Daniela; Kirsch, Peter; Meyer‐Lindenberg, Andreas; Zink, Mathias

doi:10.1016/j.schres.2012.06.025

Cited by 90 publications

(101 citation statements)

References 42 publications

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“…[19][20][21][22] In contrast, there is now meta-analytic support for reduced VS activation in patients with established schizophrenia, 24 but results on the individual study level are very inconsistent. 15,16,23,25,31,35,59,62,63 These mixed findings support the notion that striatal alterations in psychosis do not solely consist of hypo-activation but vary between different stages (early vs chronic) and different forms of psychosis (schizophrenia vs non-schizophrenia). In line with this notion, patients with FEP-SZ showed higher striatal activity compared to other individuals within the psychosis continuum.…”

Section: Discussionsupporting

confidence: 68%

“…Compared to healthy controls (HCs), differences in ventral striatal activity were observed in studies in patients with first-episode schizophrenia (FEP-SZ) and first-degree relatives of patients with schizophrenia. [15][16][17][18] Other studies including patients with broadly defined first-episode psychosis (not restricted to schizophrenia and schizophreniform disorder) or individuals at-risk for psychosis did not report any group differences, but focused more on the relationship with symptom expression. [19][20][21][22][23] This work supports the idea that on a group level reduced activation of the striatum may be more strongly related to schizophrenia or chronic forms of psychosis than to psychotic disorders in general.…”

Section: Introductionmentioning

confidence: 99%

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Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis

Kirschner

Hager

Muff

et al. 2016

SCHBUL

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Striatal abnormalities play a crucial role in the pathophysiology of schizophrenia. Growing evidence suggests an association between aberrant striatal activity during reward anticipation and symptom dimensions in schizophrenia. However, it is not clear whether this holds across the psychosis continuum. The aim of the present study was to investigate alterations of ventral striatal activation during reward anticipation and its relationship to symptom expression in persons with schizotypal personality traits (SPT) and first-episode psychosis. Twenty-six individuals with high SPT, 26 patients with non-affective first-episode psychosis (including 13 with brief psychotic disorder (FEP-BPD) and 13 with first-episode schizophrenia [FEP-SZ]) and 25 healthy controls underwent event-related functional magnetic resonance imaging while performing a variant of the Monetary Incentive Delay task. Ventral striatal activation was positively correlated with total symptom severity, in particular with levels of positive symptoms. This association was observed across the psychosis continuum and within each subgroup. Patients with FEP-SZ showed the strongest elevation of striatal activation during reward anticipation, although symptom levels did not differ between groups in the psychosis continuum. While our results provide evidence that variance in striatal activation is mainly explained by dimensional symptom expression, patients with schizophrenia show an additional dysregulation of striatal activation. Trans-diagnostic approaches are promising in order to disentangle dimensional and categorical neural mechanisms in the psychosis continuum.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis

Kirschner

Hager

Muff

et al. 2016

SCHBUL

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“…5 It has further been shown that VS activation during reward prediction was negatively related to positive psychotic symptoms in patients with FEP. 4,5 Reward processing is critically mediated by dopamine, 6,7 and the VS response to reward-predicting cues is likely triggered by dopamine activity. 8,9 A previous fMRI study in patients with chronic schizophrenia showed that the VS response during reward prediction was reduced only in patients treated with typical antipsychotics, whereas no difference was observed between healthy controls and patients treated with atypical medication.…”

mentioning

confidence: 99%

Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis

Schmidt

Palaniyappan

Smieskova

et al. 2016

jpn

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IntroductionOur brain is constantly exposed to a wide variety of stimuli, which compete for limited cognitive resources. External stimu li are processed depending on their salience so as to ignore predictable, state and task-irrelevant events while enhancing resource allocation in order to process unexpected or state-and task-relevant events. Efficient prediction of salient stimuli, such as those of rewards, is thus essential for adapting ongoing behaviour. This process requires the ability to learn that a neutral stimulus becomes emotionally endowed owing to its association with primary reinforcement. 1 Behavioural and fMRI studies have demonstrated impairments in patients with psychosis when anticipating reward.2 Relative to controls, behavioural evidence indicated that patients with rst-episode psychosis (FEP) exhibited less reactivity to reward-predicting cues.3 Functional MRI studies during reward prediction have reported reduced activity in diverse brain regions, including the ventral striatum (VS), 4,5 anterior cingulate cortex (ACC), midbrain, thalamus and cerebellum, of unmedicated patients with FEP compared with controls. 5 It has further been shown that VS activation during reward prediction was negatively related to positive psychotic symptoms in patients with FEP. 4,5 Reward processing is critically mediated by dopamine, 6,7 and the VS response to reward-predicting cues is likely triggered by dopamine activity. 8,9 A previous fMRI study in patients with chronic schizophrenia showed that the VS response during reward prediction was reduced only in patients treated with typical antipsychotics, whereas no difference was observed between healthy controls and patients treated with atypical medication. 10 In line with this nding in patients with chronic schizophrenia, the reduced baseline VS activation during reward prediction seen in patients with FEP relative to healthy controls has been reported to be normalized after 6 weeks of monotherapy with atypical antipsychotics.11 The largest improvement in positive symptoms was seen in patients with the highest VS signal increase.11 Although not speci cally during reward processing, a recent resting-state fMRI study in patients Background: Increasing evidence indicates that psychosis is associated with abnormal reward processing. Imaging studies in patients with first-episode psychosis (FEP) have revealed reduced activity in diverse brain regions, including the ventral striatum, insula and anterior cingulate cortex (ACC), during reward prediction. However, whether these reductions in local brain activity are due to altered connectivity has rarely been explored. Methods: We applied dynamic causal modelling and Bayesian model selection to fMRI data during the Salience Attribution Task to investigate whether patients with FEP showed abnormal modulation of connectivity between the ventral striatum, insula and ACC induced by rewarding cues and whether these changes were related to positive psychotic symptoms and atypical antipsychotic medication. Results: The model...

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“…However, previous studies that conducted incentive delay tasks with schizophrenia patients mainly focused on monetary rewards. There was no difference in task performance between schizophrenia patients and healthy controls apart from slower reaction times in patients [26,[30][31][32] and no evidence for reduced discrimination between neutral and reward cues was found [28,31].…”

Section: Reward Processing In Schizophreniamentioning

confidence: 71%

“…Results of several functional neuroimaging studies on monetary reward anticipation in schizophrenic patients are consistent with this interpretation. Unmedicated and drug-naïve patients show significantly reduced activations in the brain's reward system during the anticipation of monetary gains [26][27][28], which correlated with negative symptoms.…”

Section: Reward Processing In Schizophreniamentioning

confidence: 99%

Anticipation of Social and Monetary Rewards in Schizophrenia

Hanewald¹,

Behrens²,

Gruppe³

et al. 2017

J Psychiatry

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Ventral striatal activation during attribution of stimulus saliency and reward anticipation is correlated in unmedicated first episode schizophrenia patients

Cited by 90 publications

References 42 publications

Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis

Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis

Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis

Anticipation of Social and Monetary Rewards in Schizophrenia

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