). CME Objectives: On completion of this article, the reader should be able to summarize the role of synthetic and biologic materials in the operative management of pelvic organ prolapse.Pelvic organ prolapse is a spectrum of anatomical abnormalities associated with pelvic floor dysfunction and abnormal descent of the rectum and other abdominal structures into the pelvis. It results from the loss of support to the structures contained within the bony pelvis: from anterior to posterior, the bladder, uterus, vagina, and rectum. Frequently, diastasis of the levator ani, an abnormally deep cul-de-sac, a redundant sigmoid colon, a patulous anal sphincter, and/or the loss of rectal sacral attachments are present.1-4 Enterocele, rectocele, rectal prolapse, and total pelvic organ prolapse are benign conditions, which cause significant morbidity including pelvic discomfort, chronic drainage of blood, and/or mucous from the anus as well fecal incontinence and constipation and obstructed defecation symptoms.
5-9The development of pelvic organ prolapse is multifactorial. A combination of genetic and acquired factors, including pregnancy, increased parity, hormonal deficiencies, myopathy, neuropathy, obesity, smoking, pulmonary disease, and obstipation, contributes to the weakening of the pelvic floor.10 Several studies have demonstrated that these factors disturb the pelvic floor tissues at a molecular level, altering the composition, quantity, and organization of collagen, elastin, and smooth muscle in the urogenital tissues.
11,12Several studies have demonstrated a total decrease in the overall collagen content within the supportive pelvic tissues of patients with pelvic organ prolapse. Additionally, the ratio of collagen III/I is altered favoring an increase in collagen III, which is more compliant and distensible. The increased turnover of immature collagen and decreased elastin levels Keywords ► pelvic organ prolapse ► ventral mesh rectopexy ► biologic mesh
AbstractPelvic organ prolapse is a significant medical problem that poses a diagnostic and management dilemma. These diseases cause serious morbidity in those affected and treatment is sought for relief of pelvic pain, rectal bleeding, chronic constipation, obstructed defecation, and fecal incontinence. Numerous procedures have been proposed to treat these conditions; however, the search continues as colorectal surgeons attempt to find the procedure that would optimally treat these conditions. The use of prosthetics in the repair of pelvic organ prolapse has become prevalent as the benefits of their use are realized. While advances in biologic mesh and new surgical techniques promise improved functional outcomes with decreased complication rates without de novo symptoms, the debate concerning the best prosthetic material, synthetic or biologic, remains controversial. Furthermore, laparoscopic ventral mesh rectopexy has emerged as a procedure that could potentially fill this role and is rapidly becoming the procedure of choice for the surgical treatment of pelvic org...