Ventral pallidum self-stimulation induces stimulus dependent increase in c-fos expression in reward-related brain regions

Panagis, George; Nomikos, G.G.; Miliaressis, Elefthérios; Chergui, Karima; Kastellakis, Andreas; Svensson, Torgny H.; Spyraki, Christina

doi:10.1016/s0306-4522(96)00471-x

Cited by 62 publications

(33 citation statements)

References 46 publications

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“…We note that studies of the NAc and caudal VP have demonstrated electrophysiological coding of taste hedonic reward (Cromwell et al, 2005;Roitman et al, 2005;Tindell et al, 2006) and reported opioid-related bidirectional interaction between NAc and VP sites (Hakan et al, 1994;Panagis et al, 1997;Napier and Mitrovic, 1999). Also, conceivably, the hedonic NAc-VP circuit identified here might also mediate the hedonic effects of opioid agents on subjective ratings of food palatability in humans (Yeomans and Gray, 1996;Drewnowski, 1997).…”

Section: Discussionmentioning

confidence: 55%

Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum

Smith¹,

Berridge²

2007

J. Neurosci.

397

307

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-Opioid stimulation of cubic millimeter hedonic hotspots in either the nucleus accumbens shell (NAc) or the ventral pallidum (VP) amplifies hedonic "liking" reactions to sweetness and appetitive "wanting" for food reward. How do these two NAc-VP hotspots interact? To probe their interaction and limbic circuit properties, we assessed whether opioid activation of one hotspot recruited the other hotspot (neurobiologically) and whether opioid hedonic and incentive motivational amplification by either opioid hotspot required permissive opioid coactivation in the other (behaviorally). We found that NAc and VP hotspots reciprocally modulated Fos expression in each other and that the two hotspots were needed together to enhance sucrose "liking" reactions, essentially cooperating within a single hedonic NAc-VP circuit. In contrast, the NAc hotspot dominated for opioid stimulation of eating and food intake ("wanting"), independent of VP activation. This pattern reveals differences between limbic opioid circuits that control reward "liking" and "wanting" functions.

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Section: Discussionmentioning

confidence: 55%

Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum

Smith¹,

Berridge²

2007

J. Neurosci.

397

307

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“…We then explored whether acute and subchronic PCP treatment differentially activated c-fos expression in mice brain, as a surrogate marker of neuronal activity (Dragunow and Faull 1989;Konkle and Bielajew 2004;Panagis et al 1997;Sager et al 1988). Acute PCP induced a similar c-fos expression in mice than we previously described in rats using the same methodology (Kargieman et al 2007;Santana et al 2011).…”

Section: Discussionmentioning

confidence: 99%

PCP-based mice models of schizophrenia: differential behavioral, neurochemical and cellular effects of acute and subchronic treatments

2015

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“…Rats were anesthetized with a mixture of ketamine (100 mg/kg) and xylazine (10 mg/kg) for the stereotaxic placement of electrodes (lateral, 2.6; anterior, Ϫ0.46; D, 7.3). The caudal half of the VP was targeted based on prior studies indicating possible reward roles for this region (Cromwell and Berridge, 1993;Johnson et al, 1993;Panagis et al, 1997). Electrodes consisted of twisted bundles of eight wires (15 m tungsten or platinum iridium) (Jaeger et al, 1990).…”

Section: Methodsmentioning

confidence: 99%

“…It integrates GABA, glutamate, opioid, and dopamine signals from nucleus accumbens, striatum, amygdala, and prefrontal cortex (Johnson and Napier, 1997;Olive and Maidment, 1998;Kelley, 1999;Zahm, 2000). In addition, the VP transmits reciprocal information with nucleus accumbens (Groenewegen et al, 1993) and drives ascending signals to prefrontal cortex via dorsomedial thalamus and descending signals to ventral tegmentum and brainstem targets (McAlonan et al, 1993;Panagis et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Ventral Pallidal Representation of Pavlovian Cues and Reward: Population and Rate Codes

Tindell

Berridge²,

Aldridge³

2004

J. Neurosci.

114

128

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We recorded neural activity in the ventral pallidum (VP) while rats learned a pavlovian reward association. Rats learned to distinguish a tone that predicted sucrose pellets (CSϩ) from a different tone that predicted nothing (CSϪ). Many VP units became responsive to CSϩ, but few units responded to CSϪ. When two CSϩ were encountered sequentially, the earliest predictor of reward became most potent. Many VP units were also activated when the sucrose reward was received [unconditioned stimulus (UCS)]. These VP units for UCS remained responsive to sucrose reward after learning, even when sucrose was already predicted by CSϩ. Neural representation of reward learning and reward itself was characterized by population codes. The population of units that responded to CSϩ increased with learning, whereas the population that responded to UCS did not change. A relative firing rate code also represented the identities of conditioned stimuli and UCS. Firing rate differences among stimuli were acquired early and remained stable during subsequent training, whereas population codes and behavioral conditioned responses continued to develop during subsequent training. Thus, the VP makes use of dynamic CS population and rate codes to encode pavlovian reward cues in reward learning and uses stable UCS population and firing codes to encode sucrose reward itself.

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Ventral pallidum self-stimulation induces stimulus dependent increase in c-fos expression in reward-related brain regions

Cited by 62 publications

References 46 publications

Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum

Opioid Limbic Circuit for Reward: Interaction between Hedonic Hotspots of Nucleus Accumbens and Ventral Pallidum

PCP-based mice models of schizophrenia: differential behavioral, neurochemical and cellular effects of acute and subchronic treatments

Ventral Pallidal Representation of Pavlovian Cues and Reward: Population and Rate Codes

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