Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior

Palmer, Dakota; Cayton, Christelle A.; Scott, Alexandra; Lin, Iris; Newell, Bailey; Paulson, Anika; Weberg, Morgan; Richard, Jocelyn M.

doi:10.1016/j.celrep.2023.113669

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2024

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Cited by 5 publications

(1 citation statement)

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“… 17 VP GABA neurons have reciprocal connections with the NAc and project to the lateral hypothalamus, thalamus, and ventral tegmental area (VTA). 8 , 58 , 59 Importantly, VP GABA neurons have a crucial role in reward processing. Activating VP GABA neurons is reinforcing, 9 , 17 , 60 and VP GABA neurons demonstrate increased calcium activity in response to reward-predictive cues.…”

Section: Discussionmentioning

confidence: 99%

Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli

Kim,

Ananth,

Desai

et al. 2024

Cell Reports

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Section: Discussionmentioning

confidence: 99%

Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli

Kim,

Ananth,

Desai

et al. 2024

Cell Reports

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A ventral pallidal-thalamocortical circuit mediates the cognitive control of instrumental action

Leung,

Chieng,

Becchi

et al. 2024

Current Biology

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Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition

Richard,

Armstrong,

Newell

et al. 2024

Preprint

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Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, its role in behavioral responses to Pavlovian alcohol cues has not previously been established. Here, we tested the impact of optogenetic inhibition of ventral pallidum on Pavlovian-conditioned alcohol-seeking in male Long Evans rats. Rats underwent Pavlovian conditioning with an auditory cue predicting alcohol delivery to a reward port and a control cue predicting no alcohol delivery, until they consistently entered the reward port more during the alcohol cue than the control cue. We then tested the within-session effects of optogenetic inhibition during 50% of cue presentations. We found that optogenetic inhibition of ventral pallidum during the alcohol cue reduced port entry likelihood and time spent in the port, and increased port entry latency. Overall, these results suggest that normal ventral pallidum activity is necessary for Pavlovian alcohol-seeking.

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Ventral pallidum neurons projecting to the ventral tegmental area reinforce but do not invigorate reward-seeking behavior

Cited by 5 publications

References 63 publications

Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli

Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli

A ventral pallidal-thalamocortical circuit mediates the cognitive control of instrumental action

Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition

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