Ventral hernia repair using bioresorbable poly-4-hydroxybutyrate mesh in clean and contaminated surgical fields: a systematic review and meta-analysis

Contemporary Abdominal Wall Reconstruction: Emerging Techniques and Trends

“…Over six studies and 472 patients, the authors found that the rate of surgical site occurrence in contaminated cases similar to the aforementioned study was 35%, and in clean cases it was 14% [33]. Of interest, they noted a recurrence rate of 4% in contaminated cases using biosynthetic mesh in comparison to the 20.5% in biologic mesh and 4% in permanent synthetic mesh reported in the literature [33]. In clean cases, the authors discovered an 8% recurrence rate with biosynthetic mesh and in comparison reported 18% with biologic mesh and 6% with permanent synthetic mesh [33].…”

“…Of interest, they noted a recurrence rate of 4% in contaminated cases using biosynthetic mesh in comparison to the 20.5% in biologic mesh and 4% in permanent synthetic mesh reported in the literature [33]. In clean cases, the authors discovered an 8% recurrence rate with biosynthetic mesh and in comparison reported 18% with biologic mesh and 6% with permanent synthetic mesh [33]. These data indicate that biosynthetic mesh may be more effective than biologic mesh at reducing recurrence and surgical site infection with a lower cost.…”

“…In comparison, the surgical site occurrence rates for biologic mesh found in the literature range from 50 to 63% in similarly contaminated fields [20]. A systematic review and meta-analysis further pursued the outcomes of biosynthetic mesh in contaminated and clean fields [33]. Over six studies and 472 patients, the authors found that the rate of surgical site occurrence in contaminated cases similar to the aforementioned study was 35%, and in clean cases it was 14% [33].…”

“…Biosynthetic mesh is a novel attempt to strike the balance between biologic and permanent synthetic meshes. A common composition is poly-4-hydroxybutyrate, a monofilament polymer synthesized from a monomer derived from E. coli, which is fully resorbed by the body in 12 to 18 months [32,33]. It has been linked to lower rates of recurrence and cost than biologic mesh while retaining the advantages derived from the absorptive nature of biologic mesh [33].…”

“…A systematic review and meta-analysis further pursued the outcomes of biosynthetic mesh in contaminated and clean fields [33]. Over six studies and 472 patients, the authors found that the rate of surgical site occurrence in contaminated cases similar to the aforementioned study was 35%, and in clean cases it was 14% [33]. Of interest, they noted a recurrence rate of 4% in contaminated cases using biosynthetic mesh in comparison to the 20.5% in biologic mesh and 4% in permanent synthetic mesh reported in the literature [33].…”