Ventral and dorsal visual pathways exhibit abnormalities of static and dynamic connectivities, respectively, in patients with schizophrenia

Deng, Yaotang; Li, Kai; Cheng, Dongliang; Zhang, Jingyu; Chen, Hui; Chen, Bingguang; Li, Yingjia; Wang, Wensheng; Kong, Youyong; Wen, Gen

doi:10.1016/j.schres.2018.12.005

Cited by 21 publications

(14 citation statements)

References 43 publications

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“…Increased variance of connectivity was also detected in schizophrenia within the salience network 49 . Therefore, our dynamic rsFC findings under esketamine might mirror dynamic rsFC findings in schizophrenia that show altered connectivity in sensory processing networks 46 , more specifically in visual processing networks 48 . Our results therefore further corroborate the concept of utilizing ketamine as a model for psychosis 6–10 .…”

Section: Discussionsupporting

confidence: 66%

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Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks

Spies

Klöbl

Höflich

et al. 2019

Sci Rep

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Numerous studies demonstrate ketamine’s influence on resting-state functional connectivity (rsFC). Seed-based and static rsFC estimation methods may oversimplify FC. These limitations can be addressed with whole-brain, dynamic rsFC estimation methods. We assessed data from 27 healthy subjects who underwent two 3 T resting-state fMRI scans, once under subanesthetic, intravenous esketamine and once under placebo, in a randomized, cross-over manner. We aimed to isolate only highly robust effects of esketamine on dynamic rsFC by using eight complementary methodologies derived from two dynamic rsFC estimation methods, two functionally defined atlases and two statistical measures. All combinations revealed a negative influence of esketamine on dynamic rsFC within the left visual network and inter-hemispherically between visual networks (p < 0.05, corrected), hereby suggesting that esketamine’s influence on dynamic rsFC is highly stable in visual processing networks. Our findings may be reflective of ketamine’s role as a model for psychosis, a disorder associated with alterations to visual processing and impaired inter-hemispheric connectivity. Ketamine is a highly effective antidepressant and studies have shown changes to sensory processing in depression. Dynamic rsFC in sensory processing networks might be a promising target for future investigations of ketamine’s antidepressant properties. Mechanistically, sensitivity of visual networks for esketamine’s effects may result from their high expression of NMDA-receptors.

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Section: Discussionsupporting

confidence: 66%

“…Altered connectivity between visual, auditory, sensorimotor, and subcortical regions was shown 46 . In addition, dynamic rsFC studies in schizophrenia showed increased temporal 47 and regional variability 48 in visual processing networks. Increased variance of connectivity was also detected in schizophrenia within the salience network 49 .…”

Section: Discussionmentioning

confidence: 99%

Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks

Spies

Klöbl

Höflich

et al. 2019

Sci Rep

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“… 50 Another found abnormal functional connectivity throughout the dorsal and ventral visual pathways. 51 A third study found diminished functional connectivity within visual cortex in SZ, which was correlated with impairments on a perceptual closure task. 52 …”

Section: Discussionmentioning

confidence: 98%

Structural and Functional Connectivity of Visual Cortex in Schizophrenia and Bipolar Disorder: A Graph-Theoretic Analysis

Reavis

Lee

Altshuler

et al. 2020

Schizophrenia Bulletin Open

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Visual processing abnormalities in schizophrenia (SZ) are poorly understood, yet predict functional outcomes in the disorder. Bipolar disorder (BD) may involve similar visual processing deficits. Converging evidence suggests that visual processing may be relatively normal at early stages of visual processing such as early visual cortex (EVC) but that processing abnormalities may become more pronounced by mid-level visual areas such as lateral occipital cortex (LO). However, little is known about the connectivity of the visual system in SZ and BD. If the flow of information to, from, or within the visual system is disrupted by reduced connectivity, this could help to explain perceptual deficits. In the present study, we performed a targeted analysis of the structural and functional connectivity of the visual system using graph theoretic metrics in a sample of 48 SZ, 46 BD, and 47 control participants. Specifically, we calculated parallel measures of local efficiency for EVC and LO from both diffusion weighted imaging data (structural) and resting state (functional) imaging data. We found no structural connectivity differences between the groups. However, there was a significant group difference in functional connectivity and a significant group-by-region interaction driven by reduced LO connectivity in SZ relative to HC, whereas BD was approximately intermediate to the other two groups. We replicated this pattern of results using a different brain atlas. These findings support and extend theoretical models of perceptual dysfunction in SZ, providing a framework for further investigation of visual deficits linked to functional outcomes in SZ and related disorders.

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“…Condition-specific brain states are characterised by reduced and less defined functional connectivity and more frequent recurrence [74,[95][96][97][98][99][100][101]. A higher temporal variability of dFC time-courses, was reported in schizophrenic patients in several attention, perceptual and emotion regulation RSNs [102][103][104][105][106], and related to a disruption in perceptual functions [105,107]. In contrast, lower temporal variability was reported for the default mode and fronto-parietal networks [105,107].…”

Section: Functional Connectivitymentioning

confidence: 99%

Brain network analyses in clinical neuroscience

Sokolov

Granziera²,

Fischi-Gómez³

et al. 2019

Swiss Arch Neurol Psychiatr Psychother

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Ventral and dorsal visual pathways exhibit abnormalities of static and dynamic connectivities, respectively, in patients with schizophrenia

Cited by 21 publications

References 43 publications

Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks

Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks

Structural and Functional Connectivity of Visual Cortex in Schizophrenia and Bipolar Disorder: A Graph-Theoretic Analysis

Brain network analyses in clinical neuroscience

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