Ventilatory support during whole-body row training improves oxygen uptake efficiency in patients with high-level spinal cord injury: A pilot study

Vivodtzev, Isabelle; Napolitano, Anthony; Picard, Glen; Taylor, J. Andrew

doi:10.1016/j.rmed.2020.106104

Cited by 2 publications

(1 citation statement)

References 10 publications

(16 reference statements)

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“…Indeed, limited respiratory function in those with high-level injuries may be a limiting factor to whole-body exercise via functional electrical stimulation -FES- [12] which allows much greater exercise intensities, such that muscle metabolic demand exceeds ventilatory capacity [13]. We recently found that if respiratory function is improved via ventilatory support during exercise, this limitation can be overcome, and cardioprotective levels of exercise intensity can be achieved [14].…”

Section: Respiratory Impactmentioning

confidence: 99%

Serotonin 1A Receptor Pharmacotherapy and Neuroplasticity in Spinal Cord Injury

et al. 2022

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Spinal cord injury is associated with damage in descending and ascending pathways between brainstem/cortex and spinal neurons, leading to loss in sensory-motor functions. This leads not only to locomotor reduction but also to important respiratory impairments, both reducing cardiorespiratory engagement, and increasing cardiovascular risk and mortality. Moreover, individuals with high-level injuries suffer from sleep-disordered breathing in a greater proportion than the general population. Although no current treatments exist to restore motor function in spinal cord injury (SCI), serotoninergic (5-HT) 1A receptor agonists appear as pharmacologic neuromodulators that could be important players in inducing functional improvements by increasing the activation of spared motoneurons. Indeed, single therapies of serotoninergic 1A (5-HT1A) agonists allow for acute and temporary recovery of locomotor function. Moreover, the 5-HT1A agonist could be even more promising when combined with other pharmacotherapies, exercise training, and/or spinal stimulation, rather than administered alone. In this review, we discuss previous and emerging evidence showing the value of the 5HT1A receptor agonist therapies for motor and respiratory limitations in SCI. Moreover, we provide mechanistic hypotheses and clinical impact for the potential benefit of 5-HT1A agonist pharmacology in inducing neuroplasticity and improving locomotor and respiratory functions in SCI.

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Section: Respiratory Impactmentioning

confidence: 99%

Serotonin 1A Receptor Pharmacotherapy and Neuroplasticity in Spinal Cord Injury

et al. 2022

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An analysis of the effectiveness of rehabilitation protocols for patients with spinal cord injury: A systematic review

Lee,

Jeoung

2023

J Public Health (Berl.)

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Aim SCI may cause loss of sensory function, paralysis, and limited functional mobility. The specificity of SCI has expanded the scope of medical trials and given rise to therapeutic options that incorporate new technologies with robotics and electronic devices. We aimed to identify various therapeutic options and develop effective treatment regimens. Methods We conducted the systematic review using the following digital databases: MEDLINE/PubMed and Google Scholar. We focused on publications published between 2012 and 2023 and The following primary terms were searched: “Spinal cord injury rehabilitation,” “Spinal cord injury exercise,” and “Spinal cord injury therapy,” with the Boolean operator “AND/OR” used for additional searches. A total of 110 relevant articles were identified during the selection process. After screening and assessing eligibility, the final 17 studies were included in this systematic review Results & conclusion The current paper gave a taxonomy of electrical instrumentation and traditional rehabilitation technologies. We also discovered that FES is used as a comprehensive regimen that involves both the upper and lower extremities, and that locomotor training using robots is beneficial in improving walking ability. We discovered that diversified training programs using conventional methods concentrated on the physical independence of patients with chronic SCI.

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Ventilatory support during whole-body row training improves oxygen uptake efficiency in patients with high-level spinal cord injury: A pilot study

Cited by 2 publications

References 10 publications

Serotonin 1A Receptor Pharmacotherapy and Neuroplasticity in Spinal Cord Injury

Serotonin 1A Receptor Pharmacotherapy and Neuroplasticity in Spinal Cord Injury

An analysis of the effectiveness of rehabilitation protocols for patients with spinal cord injury: A systematic review

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