Ventilatory Support During Exercise in Patients With Pulmonary Tuberculosis Sequelae

Tsuboi, Taijū; Ohi, Motoharu; Chin, Kazuo; Hirata, Hinako; Otsuka, Naoki; Kita, Hideo; Kuno, Kenshi

doi:10.1378/chest.112.4.1000

Cited by 36 publications

(31 citation statements)

References 24 publications

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“…Desaturations during unaided exercise have been shown in patients with severe COPD [17] and pulmonary tuberculosis sequelae [18]. However, the present study is the first to demonstrate a fall in Pa,O 2 during simple walking, even when supplemental oxygen is applied in these patients, and a significant increase in Pa,O 2 , even during walking, when NPPV is administered in addition to supplemental oxygen.…”

Section: Discussionsupporting

confidence: 41%

“…The primary outcome parameter, which was the change in arterial oxygen tension (Pa,O 2 ) during 6MWT, served as the parameter determining the minimal sample size to ensure powerful testing on intervention. Assuming a power of 90% with an a-error of 0.05 to detect a mean¡SD change in Pa,O 2 of 1.86¡1.39 kPa, according to previous findings [18] and the current authors' clinical experience, at least nine patients were needed for the analysis. In order to increase the power of the analysis, the target sample size was 20 patients.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, oxygenation has been shown to be significantly improved in patients already receiving NPPV for treatment of pulmonary tuberculosis sequelae, when NPPV was used during exercise compared with unaided exercise [18]. Therefore, it was hypothesised that the application of NPPV would result in the avoidance of exercise-induced hypoxaemia AFFILIATIONS Dept of Pneumology, University Hospital Freiburg, Germany.…”

mentioning

confidence: 99%

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Noninvasive ventilation during walking in patients with severe COPD: a randomised cross-over trial

Dreher¹,

Storre²,

Windisch³

2007

European Respiratory Journal

101

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It was hypothesised that noninvasive positive-pressure ventilation (NPPV) applied during walking prevents exercise-induced hypoxaemia and improves exercise performance in severe chronic obstructive pulmonary disease (COPD) patients already receiving long-term NPPV.A total of 20 COPD patients (mean¡SD age 65.1¡8.7 yrs, forced expiratory volume in one second 27¡8% predicted and total lung capacity 116¡27% pred) reporting dyspnoea, even during mild exertion, underwent two 6-min walking tests with a rollator and supplemental oxygen (2.1¡0.9 L?min -1 ) in a randomised cross-over design: with and without pressure-limited NPPV as used at home (inspiratory:expiratory pressure 2.9¡0.44:0.4¡0.1 kPa (29¡4:4¡1 mbar), respiratory frequency 20¡2 breaths?min -1 ).The arterial oxygen tension significantly increased by 1.39¡1.43 kPa (95% confidence interval (CI) 0.71-2.07 kPa) after walking with NPPV, but significantly decreased by 1.43¡1.06 kPa (95% CI -1.92 --0.94 kPa) without NPPV. Dyspnoea, as assessed by the Borg dyspnoea scale, significantly decreased from 6 (interquartile range (IQR) 4.5-10) to 4 (1.5-4.5) and walking distance significantly increased from 209 (IQR 178-279) to 252 (203-314) m when walking was NPPV-aided.In chronic hypercapnic chronic obstructive pulmonary disease, high-intensity noninvasive positive-pressure ventilation can also be administered during walking with unchanged ventilator settings compared with settings used at rest, thus resulting in improved oxygenation, decreased dyspnoea and increased walking distance. Therefore, noninvasive positive-pressure ventilation during walking could prevent hypoxia-induced complications and could, in future, play a role in palliative care.

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Section: Discussionsupporting

confidence: 41%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Noninvasive ventilation during walking in patients with severe COPD: a randomised cross-over trial

Dreher¹,

Storre²,

Windisch³

2007

European Respiratory Journal

101

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“…On the other hand, optimal exercise intensity for patients with PTS has been unclear because of the small number of reports on exercise training for them (3)(4)(5) (15,19). We tried to minimize the learning effect by having patients practice treadmill walking one day before the treadmill test and by using the 6MWT in the manner described in Steele (19 …”

Section: Discussionmentioning

confidence: 99%

“…are surprisingly rare (3)(4)(5) given that PTS cases are the second most numerous, after COPD cases, among patients with underlying diseases leading to chronic respiratory failure in Japan (6).…”

Section: Exercise Training Is An Important Component In the Pulmonarymentioning

confidence: 99%

Exercise Training for the Improvement of Exercise Performance of Patients with Pulmonary Tuberculosis Sequelae

et al. 2006

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Respiratory Exercises and Noninvasive Ventilation

Bezzoli

Fanari

Codecasa

2020

Rehabilitation Interventions in the Patient With Obesity

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Ventilatory Support During Exercise in Patients With Pulmonary Tuberculosis Sequelae

Cited by 36 publications

References 24 publications

Noninvasive ventilation during walking in patients with severe COPD: a randomised cross-over trial

Noninvasive ventilation during walking in patients with severe COPD: a randomised cross-over trial

Exercise Training for the Improvement of Exercise Performance of Patients with Pulmonary Tuberculosis Sequelae

Respiratory Exercises and Noninvasive Ventilation

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