Ventilatory Responses to Acute and Sustained Hypoxia During Isoflurane Anesthesia

Sjogren, Dick; Lindahl, Sten G. E.; Sollevi, Alf

doi:10.1097/00000539-199802000-00035

Cited by 7 publications

(1 citation statement)

References 22 publications

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“…Second, acute metabolic acidosis selectively activates peripheral, not central, chemoreceptors, and its effect is abolished by halothane (0.1 MAC) [5–14]. Third, if the ventilatory response to hypercapnia is analysed mathematically into fast (peripheral) and slow (central) components, it is the former that is preferentially reduced by volatile anaesthetics [23, 29]. Finally, combining results of many human studies indicates that low dose, subanaesthetic (<0.2 MAC) volatile anaesthetics blunt the ventilatory response to hypoxia [9] but not hypercapnia [18] (Figure 3), a result which is more consistent with the notion that their effect is on the peripheral chemoreceptor rather than on central mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Volatile Anaesthetic Depression of the Carotid Body Chemoreflex-Mediated Ventilatory Response to Hypoxia: Directions for Future Research

Pandit

2014

Scientifica

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In assessing whether volatile anaesthetics directly depress the carotid body response to hypoxia it is necessary to combine in meta-analysis studies of when it is “functionally isolated” (e.g., recordings are made from its afferent nerve). Key articles were retrieved (full papers in English) and subjected to quantitative analysis to yield an aggregate estimate of effect. Results from articles that did not use such methodology were assessed separately from this quantitative approach, to see what could be learned also from a nonquantitative overview. Just 7 articles met the inclusion criteria for hypoxia and just 6 articles for hypercapnia. Within these articles, the anaesthetic (mean dose 0.75, standard deviation (SD) 0.40 minimum alveolar concentration, MAC) statistically significantly depressed carotid body hypoxic response by 24% (P = 0.041), but a similar dose (mean 0.81 (0.42) MAC) did not affect the hypercapnic response. The articles not included in the quantitative analysis (31 articles), assessed qualitatively, also indicated that anaesthetics depress carotid body function. This conclusion helps direct future research on the anaesthetic effects on putative cellular/molecular processes that underlie the transduction of hypoxia in the carotid body.

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Section: Discussionmentioning

confidence: 99%

Volatile Anaesthetic Depression of the Carotid Body Chemoreflex-Mediated Ventilatory Response to Hypoxia: Directions for Future Research

Pandit

2014

Scientifica

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Sevoflurane and isoflurane monoanesthesia abolished the phrenic long-term facilitation in rats

Marinov

Valić

Pecotić

et al. 2013

Respiratory Physiology & Neurobiology

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Effect of low‐dose volatile anaesthetics on ventilation during acute hypoxia

2002

Anaesthesia

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Research output in anaesthesia: a quantitative ranking Reports on the share of articles in some categories of biomedical journals are documented for the top-ranking countries [1-3]. It would be interesting to quantify different countries' contribution to the research output in anaesthesia. We conducted this study to elicit different countries' positions in the field of anaesthesia along with the time trend. Seven journals on anaesthesia with the highest impact factor (Pain, Anesthesiology, Anesthesia and Analgesia, Anaesthesia, British Journal of Anaesthesia, International Journal of Obstetric Anaesthesia, and Canadian Journal of Anaesthesia) were selected from the category ÔAnesthesi-ologyÕ set by the Institute for Scientific Information [4]. Journals not available in the Medline database for the entire 1991-2000 period were excluded (Acta Anaesthesiologica Scandinavica and Clinical Journal of Pain). The Medline database was searched in the 3rd week of April 2002 to elicit the number of articles (journal articles) published during 1991-2000 in these seven journals. Only journal articles were included for analyses, i.e. correspondence, editorials and news were excluded. The proportion of contributions by each of the countries was ranked in descending order. Non-parametric tests for trend were conducted to elicit any significant change over time using STATA statistical software [5]. All tests of significance were two-tailed and values of p ¼ 0.05 were considered significant.

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Ventilatory Responses to Acute and Sustained Hypoxia During Isoflurane Anesthesia

Abstract: We studied the ventilatory effects of 20 min of breathing air with low oxygen content (hypoxic) in eight women, before and during anesthesia with inhaled isoflurane. We demonstrated a persistent but blunted hypoxic ventilatory response during clinical anesthesia.

Cited by 7 publications

References 22 publications

Volatile Anaesthetic Depression of the Carotid Body Chemoreflex-Mediated Ventilatory Response to Hypoxia: Directions for Future Research

Volatile Anaesthetic Depression of the Carotid Body Chemoreflex-Mediated Ventilatory Response to Hypoxia: Directions for Future Research

Sevoflurane and isoflurane monoanesthesia abolished the phrenic long-term facilitation in rats

Effect of low‐dose volatile anaesthetics on ventilation during acute hypoxia

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