Ventilatory Responses During Submaximal Exercise in Children With Prader–Willi Syndrome

Abstract

PWS did not show impaired ventilatory responses to exercise. Hyperventilation in PWS may relate to excessive neural stimulation and metabolic cost.

Physical exercise and Prader‐Willi syndrome: A systematic review

“…Adults with PWS showed lower values of maximal oxygen uptake (~47%) and ventilatory threshold (~44%) than overweight and obese adults without PWS . A worse exercise efficiency during low‐to‐moderate aerobic exercise (ie, higher oxygen uptake or higher ventilation rate for a given muscle power output) was also reported in children with PWS compared to normal‐weight children without PWS …”

“…A consistently higher HR during submaximal exercise (12%-14%) at the same absolute workload was also reported in children with PWS compared to normal-weight or obese children. 25 With regard to blood pressure (BP), similar levels of systolic BP were found in children with or without PWS. 16,22,33 However, one study observed a higher post-exercise diastolic BP in children with PWS compared to lean and obese children without this condition (24% and 11% lower, respectively).…”

“…A total of 483 studies were identified, of which 447 did not meet the inclusion criteria. Twenty-two studies, 10,15,16,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] whose details are summarized in Tables 2 and 3 Mullins (1987)…”

“…Ten studies 10,15,16,[22][23][24][25] reported the acute effects (either physiological response or physical performance) of exercise in patients with PWS using the following types of exercise tests: cycle ergometer, 16,22,23 lower-body strength, 10,24,33 treadmill along with upper-body strength and flexibility, 15 only treadmill, 25,34 or the Bruininks-Oseretsky test to analyse motor proficiency. 35 Eight out of ten studies were carried out in children and/or adolescents, 16,[22][23][24][25] with the remainder of studies conducted in adults. 10,15 Five studies analysed cardiorespiratory responses.…”

“…10,15 Five studies analysed cardiorespiratory responses. 15,16,22,25,33 In three studies, a lower (12%-22%) peak value of exertional heart rate (HR) was observed in PWS patients compared to controls. 15,16,22 A slower HR recovery after submaximal exercise 16,33 but similar after maximal exercise 16 was observed in children with PWS compared to obese and normal-weight peers.…”