Ventilator-Induced Lung Injury Increases Systemic Inflammation in Murine Pseudomonas Aeruginosa Pneumonia

Felten, Matthias; Tan, Chunjiang; Ferencik, Sebastian; Letsiou, Eleftheria; Suttorp, Norbert; Witzenrath, Martin

doi:10.1183/13993003.congress-2019.pa2917

Cited by 1 publication

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“…VAP prevention policies are currently available; For example, measures such as raising the head of the bed 30-45 degrees, placing the patient's head higher in the post-feeding stage with a gastric tube, periods away from sedation, evaluation for timely and rapid removal of gastric ulcer prophylaxis endotracheal tube, Prophylaxis of deep vein thrombosis, oral care with chlorine hexine, maintenance of tracheal tube cuff pressure between 30 and 40 mmHg, rotation of the patient from side to side at least once every 2 hours and tracheal and pharyngeal suctioning (3). Patients with endotracheal tubes in ICU wards cannot drain lung secretions due to ineffective coughing.…”

Section: Introductionmentioning

confidence: 99%

The effect of different solutions in tracheal suctioning on the incidence of pneumonia in patients on the ventilator

Chai¹,

Liu²,

Zhao³

2022

Cell Mol Biol (Noisy-le-grand)

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Ventilator-associated pneumonia (VAP) is a common nosocomial infection in patients admitted to intensive care units (ICU), leading to prolonged stay in the ICU, increased hospital costs, and mortality. This study aimed to compare the effect of using normal saline with eucalyptus in endotracheal suctioning on the rate of ventilator-dependent pneumonia. For this purpose, a randomized clinical trial study was performed on 120 patients under a ventilator in the hospital ICU. Patients were randomly divided into control and intervention groups. The control group consisted of 60 patients who used 0.9% normal saline to dilute endotracheal secretions. The intervention group also included 60 patients treated with 0.9% normal saline with 5% eucalyptus to dilute endotracheal secretions. The sensitivity of isolated microbes was determined by the diffusion susceptibility test Kirby-Bauer disk protocol. The CDC protocol was used to diagnose VAP. 100 CFU/ml of endotracheal aspiration was considered the differentiation number between the microbe responsible for VAP and colonization. Whenever a VAP guess was made, a blood culture was done. Finally, the incidence of ventilator-associated pneumonia in the two groups was compared. The results showed that the incidence of VAP during using normal saline and normal saline with eucalyptus as a diluent for pulmonary secretions was different between the two groups (P = 0.042). Also, among infected patients with VAP, there was a difference between the types of microorganisms in the two groups (P = 0.019). Seven cases of Klebsiella pneumonia were observed in the control group, while no case of this bacterium was observed in the intervention group. In terms of the prevalence of Pseudomonas (two cases), both groups had a similar situation. These findings can reassure nurses and the treatment team that they can use normal saline solution with 5% eucalyptus during suction to dilute pulmonary secretions.

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Section: Introductionmentioning

confidence: 99%