Ventilator-Associated Pneumonia in Low Birth Weight Neonates at a Neonatal Intensive Care Unit: A Retrospective Observational Study

Lee, Pei-Lun; Lee, Wei-Te; Chen, Hsiu-Lin

doi:10.1016/j.pedneo.2015.10.014

Cited by 29 publications

(29 citation statements)

References 31 publications

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“…VAP is associated to some secondary short‐term outcomes and this consistent with available data in neonates and older patients . It is interesting to notice that these findings have been found despite our aggressive policy of noninvasive respiratory support .…”

Section: Discussionsupporting

confidence: 84%

“…The VAP definition is also disputable, as it is not dedicated to neonates but generalized for infants aged less than 12 months, although this is the only available definition so far. Ours is a relatively small study, although comparable to previous studies in terms of sample size, VAP incidence and aetiology . Our study has an explanatory design.…”

Section: Discussionsupporting

confidence: 71%

“…VAP is associated to some secondary short-term outcomes and this consistent with available data in neonates and older patients. 4,[6][7][8][9][10][11] It is interesting to notice that these findings have been found despite our aggressive policy of noninvasive respiratory support. 17 VAP does not seem to increase mortality and long-term respiratory morbidity: this may have various explanations.…”

Section: Discussionmentioning

confidence: 89%

“…Ours is a relatively small study, although comparable to previous studies in terms of sample size, VAP incidence and aetiology. [6][7][8][9][10][11] Our study has an explanatory design.…”

Section: Discussionmentioning

confidence: 99%

“…Only scanty data about short‐term outcomes of neonates with VAP are available. Neonatal VAP seems associated with increased mortality (especially in extremely preterm neonates), while longer duration of IMV, hospital, and NICU stay were also reported.…”

Section: Introductionmentioning

confidence: 99%

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Short‐ and long‐term respiratory outcomes in neonates with ventilator‐associated pneumonia

Dell’Orto

Raschetti

Centorrino

et al. 2019

Pediatric Pulmonology

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Background and Objective Ventilator‐associated pneumonia (VAP) is a common nosocomial infection in critical care settings and might have important long‐term consequences in neonates. Our aim is to clarify the short‐ and long‐term respiratory outcomes of neonates affected by VAP. Methods Prospective, population‐based, cohort study with 12 months follow‐up based on clinical examinations and diary‐based respiratory morbidity score, conducted in an academic tertiary referral neonatal unit with dedicated follow‐up program. Results A total of 199 inborn neonates consecutively ventilated for at least 48 hours were eligible for the study. One hundred fifty‐one were finally enrolled and classified as “exposed” or “unexposed” to VAP, if they fulfilled (or not) VAP criteria once during their stay. Bronchopulmonary dysplasia (BPD) incidence was significantly higher in exposed (75%) than in unexposed babies (26.8%; relative risk [RR]: 2.8 [1.9‐4.0]; AdjRR: 3.5 [1.002‐12.7]; P = .049; number needed to harm = 2.07), although the composite BPD/mortality did not differ. Exposed patients showed longer intensive care unit stay (87 [43‐116] vs 14 [8‐52] days; St.β = 0.24; P < .0001) and duration of ventilation (15 [10‐25] vs 5 [4‐8] days; St.β = 0.29; P < .0001) than unexposed neonates. Exposed patients also showed less ventilator‐free days (11 [5‐17.7] vs 22 [14‐24] days; St.β = −0.15; P = .05) compared to unexposed. Respiratory infections, use of drugs, rehospitalization for respiratory reasons, home oxygen therapy, their composite outcome, and diary‐based clinical respiratory morbidity score were similar between the cohorts. Conclusion Neonatal VAP seems associated to higher incidence of BPD, longer ventilation, and intensive care stay but it does not affect long‐term respiratory morbidity.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 89%

“…Ours is a relatively small study, although comparable to previous studies in terms of sample size, VAP incidence and aetiology. [6][7][8][9][10][11] Our study has an explanatory design.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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